Association of P2X7 receptor +1513 (A→C) polymorphism with tuberculosis in a Punjabi population

BACKGROUND: Development of tuberculosis (TB) disease is an outcome of complex host-pathogen interactions. The purinergic P2X7 receptors are adenosine triphosphate gated molecules shown to induce killing of intracellular Mycobacterium tuberculosis, followed by apoptosis of the infected macrophage. A...

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Veröffentlicht in:	The international journal of tuberculosis and lung disease 2010-09, Vol.14 (9), p.1159-1163
Hauptverfasser:	SHARMA, S, KUMAR, V, KHOSLA, R, KAJAL, N, SARIN, B, SEHAJPAL, P
Format:	Artikel
Sprache:	eng
Schlagworte:	1513 (a/c) Polymorphism Adolescent Adult Aged Aged, 80 and over Alleles Bacterial diseases Biological and medical sciences Case-Control Studies Child Female Genetic Predisposition to Disease Genotype Human bacterial diseases Humans India Infectious diseases Male Medical sciences Middle Aged Mutation Mycobacterium tuberculosis - isolation & purification P2x7 Receptor Pneumology Polymerase Chain Reaction - methods Polymorphism, Single Nucleotide Punjabi Population Receptors, Purinergic P2X7 - genetics Respiratory system : syndromes and miscellaneous diseases Risk Factors Tuberculosis Tuberculosis - genetics Tuberculosis and atypical mycobacterial infections Young Adult
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