Low Incidence of Complications From Endoscopic Gastric Variceal Obturation With Butyl Cyanoacrylate
Background & Aims Endoscopic variceal obturation with tissue adhesive is used to control gastric variceal bleeding. We investigated the prevalence of serious complications from this therapy. Methods We performed a retrospective analysis of complications that occurred in 753 patients with gastric...
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| Veröffentlicht in: | Clinical gastroenterology and hepatology 2010-09, Vol.8 (9), p.760-766 |
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| creator | Cheng, Liu–Fang Wang, Zhi–Qiang Li, Chang–Zheng Lin, Wu Yeo, Anthony E.T Jin, Bo |
| description | Background & Aims Endoscopic variceal obturation with tissue adhesive is used to control gastric variceal bleeding. We investigated the prevalence of serious complications from this therapy. Methods We performed a retrospective analysis of complications that occurred in 753 patients with gastric variceal hemorrhages who were hospitalized in 2 tertiary referral hospitals. All patients received N -butyl-2-cyanoacrylate as therapy for endoscopic variceal obturation. Results Complications occurred in 51 patients. Thirty-three patients experienced rebleeding because of early-onset (within 3 months) extrusion of the N -butyl-2-cyanoacrylate glue cast (4.4%), 10 patients developed sepsis (1.3%), and 5 patients developed distant embolisms (0.7%; 1 pulmonary, 1 brain, and 3 splenic). One patient had major gastric variceal bleeding after endoscopic variceal obturation (0.1%), 1 developed a large gastric ulcer (0.1%), and 1 had mesentery hematoma, hemoperitoneum, and infection in the abdominal cavity (0.1%). The complication-related mortality was 0.53% (3 deaths from sepsis and 1 death from rebleeding after early-onset glue cast extrusion). Conclusions The occurrence of complications after endoscopic variceal obturation with N -butyl-2-cyanoacrylate in gastric varices treatment is rare. |
| doi_str_mv | 10.1016/j.cgh.2010.05.019 |
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We investigated the prevalence of serious complications from this therapy. Methods We performed a retrospective analysis of complications that occurred in 753 patients with gastric variceal hemorrhages who were hospitalized in 2 tertiary referral hospitals. All patients received N -butyl-2-cyanoacrylate as therapy for endoscopic variceal obturation. Results Complications occurred in 51 patients. Thirty-three patients experienced rebleeding because of early-onset (within 3 months) extrusion of the N -butyl-2-cyanoacrylate glue cast (4.4%), 10 patients developed sepsis (1.3%), and 5 patients developed distant embolisms (0.7%; 1 pulmonary, 1 brain, and 3 splenic). One patient had major gastric variceal bleeding after endoscopic variceal obturation (0.1%), 1 developed a large gastric ulcer (0.1%), and 1 had mesentery hematoma, hemoperitoneum, and infection in the abdominal cavity (0.1%). The complication-related mortality was 0.53% (3 deaths from sepsis and 1 death from rebleeding after early-onset glue cast extrusion). Conclusions The occurrence of complications after endoscopic variceal obturation with N -butyl-2-cyanoacrylate in gastric varices treatment is rare.</description><identifier>ISSN: 1542-3565</identifier><identifier>EISSN: 1542-7714</identifier><identifier>DOI: 10.1016/j.cgh.2010.05.019</identifier><identifier>PMID: 20621678</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ectopic Embolism ; Embolism - epidemiology ; Enbucrilate - adverse effects ; Enbucrilate - therapeutic use ; Endoscopy - adverse effects ; Esophageal and Gastric Varices - surgery ; Female ; Gastric Variceal Obliteration ; Gastroenterology and Hepatology ; Hemoperitoneum - epidemiology ; Hemorrhage - surgery ; Histoacryl ; Humans ; Incidence ; Male ; Middle Aged ; Peritonitis - epidemiology ; Recurrence ; Recurrent Variceal Bleeding ; Retrospective Studies ; Sepsis - epidemiology ; Stomach Ulcer - epidemiology ; Tissue Adhesives - adverse effects ; Tissue Adhesives - therapeutic use</subject><ispartof>Clinical gastroenterology and hepatology, 2010-09, Vol.8 (9), p.760-766</ispartof><rights>AGA Institute</rights><rights>2010 AGA Institute</rights><rights>Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-b6209954b68295ef70b9ddc4acebe4b964b361d97ca8569d8d31ffa81e9f98d83</citedby><cites>FETCH-LOGICAL-c450t-b6209954b68295ef70b9ddc4acebe4b964b361d97ca8569d8d31ffa81e9f98d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cgh.2010.05.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20621678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Liu–Fang</creatorcontrib><creatorcontrib>Wang, Zhi–Qiang</creatorcontrib><creatorcontrib>Li, Chang–Zheng</creatorcontrib><creatorcontrib>Lin, Wu</creatorcontrib><creatorcontrib>Yeo, Anthony E.T</creatorcontrib><creatorcontrib>Jin, Bo</creatorcontrib><title>Low Incidence of Complications From Endoscopic Gastric Variceal Obturation With Butyl Cyanoacrylate</title><title>Clinical gastroenterology and hepatology</title><addtitle>Clin Gastroenterol Hepatol</addtitle><description>Background & Aims Endoscopic variceal obturation with tissue adhesive is used to control gastric variceal bleeding. We investigated the prevalence of serious complications from this therapy. Methods We performed a retrospective analysis of complications that occurred in 753 patients with gastric variceal hemorrhages who were hospitalized in 2 tertiary referral hospitals. All patients received N -butyl-2-cyanoacrylate as therapy for endoscopic variceal obturation. Results Complications occurred in 51 patients. Thirty-three patients experienced rebleeding because of early-onset (within 3 months) extrusion of the N -butyl-2-cyanoacrylate glue cast (4.4%), 10 patients developed sepsis (1.3%), and 5 patients developed distant embolisms (0.7%; 1 pulmonary, 1 brain, and 3 splenic). One patient had major gastric variceal bleeding after endoscopic variceal obturation (0.1%), 1 developed a large gastric ulcer (0.1%), and 1 had mesentery hematoma, hemoperitoneum, and infection in the abdominal cavity (0.1%). The complication-related mortality was 0.53% (3 deaths from sepsis and 1 death from rebleeding after early-onset glue cast extrusion). Conclusions The occurrence of complications after endoscopic variceal obturation with N -butyl-2-cyanoacrylate in gastric varices treatment is rare.</description><subject>Ectopic Embolism</subject><subject>Embolism - epidemiology</subject><subject>Enbucrilate - adverse effects</subject><subject>Enbucrilate - therapeutic use</subject><subject>Endoscopy - adverse effects</subject><subject>Esophageal and Gastric Varices - surgery</subject><subject>Female</subject><subject>Gastric Variceal Obliteration</subject><subject>Gastroenterology and Hepatology</subject><subject>Hemoperitoneum - epidemiology</subject><subject>Hemorrhage - surgery</subject><subject>Histoacryl</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peritonitis - epidemiology</subject><subject>Recurrence</subject><subject>Recurrent Variceal Bleeding</subject><subject>Retrospective Studies</subject><subject>Sepsis - epidemiology</subject><subject>Stomach Ulcer - epidemiology</subject><subject>Tissue Adhesives - adverse effects</subject><subject>Tissue Adhesives - therapeutic use</subject><issn>1542-3565</issn><issn>1542-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1ERUvhAdgg71jN1HZsJxYSEoz6J43URQssLce-oR6SeLAdUN4ehxlYsOjm3mvpnCP5Owi9oWRNCZUXu7X99rhmpLyJWBOqnqEzKjhb1TXlz493JaQ4RS9T2hHCFFf1C3TKiGRU1s0ZstvwC9-O1jsYLeDQ4U0Y9r23JvswJnwVw4AvRxeSDXtv8bVJOZb9xZQJpsd3bZ7iHzH-6vMj_jTluceb2YzB2Dj3JsMrdNKZPsHr4z5Hn68uHzY3q-3d9e3m43ZluSB51UpGlBK8lQ1TArqatMo5y42FFnirJG8rSZ2qrWmEVK5xFe0601BQnWpcU52jd4fcfQw_JkhZDz5Z6HszQpiSrgUvjFgli5IelDaGlCJ0eh_9YOKsKdELWr3TBa1e0GoidLEVz9tj-tQO4P45_rIsgvcHAZQ__vQQdbJ-oep8BJu1C_7J-A__uW3vx9JD_x1mSLswxbHA01Qnpom-X7pdqqWEEMG5rH4DKEOfSw</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Cheng, Liu–Fang</creator><creator>Wang, Zhi–Qiang</creator><creator>Li, Chang–Zheng</creator><creator>Lin, Wu</creator><creator>Yeo, Anthony E.T</creator><creator>Jin, Bo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Low Incidence of Complications From Endoscopic Gastric Variceal Obturation With Butyl Cyanoacrylate</title><author>Cheng, Liu–Fang ; Wang, Zhi–Qiang ; Li, Chang–Zheng ; Lin, Wu ; Yeo, Anthony E.T ; Jin, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-b6209954b68295ef70b9ddc4acebe4b964b361d97ca8569d8d31ffa81e9f98d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Ectopic Embolism</topic><topic>Embolism - epidemiology</topic><topic>Enbucrilate - adverse effects</topic><topic>Enbucrilate - therapeutic use</topic><topic>Endoscopy - adverse effects</topic><topic>Esophageal and Gastric Varices - surgery</topic><topic>Female</topic><topic>Gastric Variceal Obliteration</topic><topic>Gastroenterology and Hepatology</topic><topic>Hemoperitoneum - epidemiology</topic><topic>Hemorrhage - surgery</topic><topic>Histoacryl</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peritonitis - epidemiology</topic><topic>Recurrence</topic><topic>Recurrent Variceal Bleeding</topic><topic>Retrospective Studies</topic><topic>Sepsis - epidemiology</topic><topic>Stomach Ulcer - epidemiology</topic><topic>Tissue Adhesives - adverse effects</topic><topic>Tissue Adhesives - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Liu–Fang</creatorcontrib><creatorcontrib>Wang, Zhi–Qiang</creatorcontrib><creatorcontrib>Li, Chang–Zheng</creatorcontrib><creatorcontrib>Lin, Wu</creatorcontrib><creatorcontrib>Yeo, Anthony E.T</creatorcontrib><creatorcontrib>Jin, Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Liu–Fang</au><au>Wang, Zhi–Qiang</au><au>Li, Chang–Zheng</au><au>Lin, Wu</au><au>Yeo, Anthony E.T</au><au>Jin, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low Incidence of Complications From Endoscopic Gastric Variceal Obturation With Butyl Cyanoacrylate</atitle><jtitle>Clinical gastroenterology and hepatology</jtitle><addtitle>Clin Gastroenterol Hepatol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>8</volume><issue>9</issue><spage>760</spage><epage>766</epage><pages>760-766</pages><issn>1542-3565</issn><eissn>1542-7714</eissn><abstract>Background & Aims Endoscopic variceal obturation with tissue adhesive is used to control gastric variceal bleeding. We investigated the prevalence of serious complications from this therapy. Methods We performed a retrospective analysis of complications that occurred in 753 patients with gastric variceal hemorrhages who were hospitalized in 2 tertiary referral hospitals. All patients received N -butyl-2-cyanoacrylate as therapy for endoscopic variceal obturation. Results Complications occurred in 51 patients. Thirty-three patients experienced rebleeding because of early-onset (within 3 months) extrusion of the N -butyl-2-cyanoacrylate glue cast (4.4%), 10 patients developed sepsis (1.3%), and 5 patients developed distant embolisms (0.7%; 1 pulmonary, 1 brain, and 3 splenic). One patient had major gastric variceal bleeding after endoscopic variceal obturation (0.1%), 1 developed a large gastric ulcer (0.1%), and 1 had mesentery hematoma, hemoperitoneum, and infection in the abdominal cavity (0.1%). The complication-related mortality was 0.53% (3 deaths from sepsis and 1 death from rebleeding after early-onset glue cast extrusion). Conclusions The occurrence of complications after endoscopic variceal obturation with N -butyl-2-cyanoacrylate in gastric varices treatment is rare.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20621678</pmid><doi>10.1016/j.cgh.2010.05.019</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ectopic Embolism Embolism - epidemiology Enbucrilate - adverse effects Enbucrilate - therapeutic use Endoscopy - adverse effects Esophageal and Gastric Varices - surgery Female Gastric Variceal Obliteration Gastroenterology and Hepatology Hemoperitoneum - epidemiology Hemorrhage - surgery Histoacryl Humans Incidence Male Middle Aged Peritonitis - epidemiology Recurrence Recurrent Variceal Bleeding Retrospective Studies Sepsis - epidemiology Stomach Ulcer - epidemiology Tissue Adhesives - adverse effects Tissue Adhesives - therapeutic use |
| title | Low Incidence of Complications From Endoscopic Gastric Variceal Obturation With Butyl Cyanoacrylate |
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