Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila
Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The mechanisms that globally orient planar polarity are not understood, and are investigated here in the Drosophila w...
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| Veröffentlicht in: | Cell 2010-09, Vol.142 (5), p.773-786 |
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| creator | Aigouy, Benoît Farhadifar, Reza Staple, Douglas B. Sagner, Andreas Röper, Jens-Christian Jülicher, Frank Eaton, Suzanne |
| description | Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The mechanisms that globally orient planar polarity are not understood, and are investigated here in the Drosophila wing using a combination of experiment and theory. Planar polarity arises during growth and PCP domains are initially oriented toward the well-characterized organizer regions that control growth and patterning. At pupal stages, the wing hinge contracts, subjecting wing-blade epithelial cells to anisotropic tension in the proximal-distal axis. This results in precise patterns of oriented cell elongation, cell rearrangement and cell division that elongate the blade proximo-distally and realign planar polarity with the proximal-distal axis. Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape.
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► The early planar polarity pattern in Drosophila wing orients to the wing margins ► Polarity is reoriented in pupal wings by epithelial remodeling and cell flow ► Hinge contraction induces remodeling by increasing epithelial tension ► Dachsous influences polarity at both stages via effects on epithelial dynamics |
| doi_str_mv | 10.1016/j.cell.2010.07.042 |
| format | Article |
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[Display omitted]
► The early planar polarity pattern in Drosophila wing orients to the wing margins ► Polarity is reoriented in pupal wings by epithelial remodeling and cell flow ► Hinge contraction induces remodeling by increasing epithelial tension ► Dachsous influences polarity at both stages via effects on epithelial dynamics</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2010.07.042</identifier><identifier>PMID: 20813263</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cadherins - metabolism ; Cell Polarity ; DEVBIO ; Drosophila melanogaster - cytology ; Drosophila melanogaster - growth & development ; Drosophila melanogaster - metabolism ; Drosophila Proteins - metabolism ; Epithelium - metabolism ; Female ; Gene Expression Regulation, Developmental ; Pupa - cytology ; Wings, Animal - cytology ; Wings, Animal - growth & development ; Wings, Animal - metabolism</subject><ispartof>Cell, 2010-09, Vol.142 (5), p.773-786</ispartof><rights>2010 Elsevier Inc.</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-e4a0bc3c008aded9a2bc3a720bb76f0986f9defa250b2258c7436e602f5c01913</citedby><cites>FETCH-LOGICAL-c465t-e4a0bc3c008aded9a2bc3a720bb76f0986f9defa250b2258c7436e602f5c01913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cell.2010.07.042$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20813263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aigouy, Benoît</creatorcontrib><creatorcontrib>Farhadifar, Reza</creatorcontrib><creatorcontrib>Staple, Douglas B.</creatorcontrib><creatorcontrib>Sagner, Andreas</creatorcontrib><creatorcontrib>Röper, Jens-Christian</creatorcontrib><creatorcontrib>Jülicher, Frank</creatorcontrib><creatorcontrib>Eaton, Suzanne</creatorcontrib><title>Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila</title><title>Cell</title><addtitle>Cell</addtitle><description>Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The mechanisms that globally orient planar polarity are not understood, and are investigated here in the Drosophila wing using a combination of experiment and theory. Planar polarity arises during growth and PCP domains are initially oriented toward the well-characterized organizer regions that control growth and patterning. At pupal stages, the wing hinge contracts, subjecting wing-blade epithelial cells to anisotropic tension in the proximal-distal axis. This results in precise patterns of oriented cell elongation, cell rearrangement and cell division that elongate the blade proximo-distally and realign planar polarity with the proximal-distal axis. Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape.
[Display omitted]
► The early planar polarity pattern in Drosophila wing orients to the wing margins ► Polarity is reoriented in pupal wings by epithelial remodeling and cell flow ► Hinge contraction induces remodeling by increasing epithelial tension ► Dachsous influences polarity at both stages via effects on epithelial dynamics</description><subject>Animals</subject><subject>Cadherins - metabolism</subject><subject>Cell Polarity</subject><subject>DEVBIO</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - growth & development</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - metabolism</subject><subject>Epithelium - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Pupa - cytology</subject><subject>Wings, Animal - cytology</subject><subject>Wings, Animal - growth & development</subject><subject>Wings, Animal - metabolism</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAURS0EgjL8AAvkHauUZ8eJE4kNKmWQkKgQiKXlOC_gKo2LnQL9exwKLFl5Ovfq-RByzGDMgOVn87HBth1ziBcgxyD4FhkxKGUimOTbZARQ8qTIpdgj-yHMAaDIsmyX7HEoWMrzdEQeJ7GCXrXugz6g8xa7PtD-FenFpw3UNXTW6k57OnOt9rZfU9t9Pz_b7oVOlzbuW7taDOSld8EtX22rD8lOo9uARz_rAXm6mj5ObpK7--vbycVdYkSe9QkKDZVJTRxL11iXmseTlhyqSuYNlEXelDU2mmdQcZ4VRoo0xxx4kxlgJUsPyOmmd-nd2wpDrxY2DE50h24VlMwEMCG-Sb4hTRwyeGzU0tuF9mvFQA0y1VwNQTXIVCBVlBlDJz_1q2qB9V_k114EzjcAxk--W_QqmGjQYG09ml7Vzv7X_wVjaYUV</recordid><startdate>20100903</startdate><enddate>20100903</enddate><creator>Aigouy, Benoît</creator><creator>Farhadifar, Reza</creator><creator>Staple, Douglas B.</creator><creator>Sagner, Andreas</creator><creator>Röper, Jens-Christian</creator><creator>Jülicher, Frank</creator><creator>Eaton, Suzanne</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100903</creationdate><title>Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila</title><author>Aigouy, Benoît ; Farhadifar, Reza ; Staple, Douglas B. ; Sagner, Andreas ; Röper, Jens-Christian ; Jülicher, Frank ; Eaton, Suzanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-e4a0bc3c008aded9a2bc3a720bb76f0986f9defa250b2258c7436e602f5c01913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cadherins - metabolism</topic><topic>Cell Polarity</topic><topic>DEVBIO</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - growth & development</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila Proteins - metabolism</topic><topic>Epithelium - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Pupa - cytology</topic><topic>Wings, Animal - cytology</topic><topic>Wings, Animal - growth & development</topic><topic>Wings, Animal - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aigouy, Benoît</creatorcontrib><creatorcontrib>Farhadifar, Reza</creatorcontrib><creatorcontrib>Staple, Douglas B.</creatorcontrib><creatorcontrib>Sagner, Andreas</creatorcontrib><creatorcontrib>Röper, Jens-Christian</creatorcontrib><creatorcontrib>Jülicher, Frank</creatorcontrib><creatorcontrib>Eaton, Suzanne</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aigouy, Benoît</au><au>Farhadifar, Reza</au><au>Staple, Douglas B.</au><au>Sagner, Andreas</au><au>Röper, Jens-Christian</au><au>Jülicher, Frank</au><au>Eaton, Suzanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2010-09-03</date><risdate>2010</risdate><volume>142</volume><issue>5</issue><spage>773</spage><epage>786</epage><pages>773-786</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The mechanisms that globally orient planar polarity are not understood, and are investigated here in the Drosophila wing using a combination of experiment and theory. Planar polarity arises during growth and PCP domains are initially oriented toward the well-characterized organizer regions that control growth and patterning. At pupal stages, the wing hinge contracts, subjecting wing-blade epithelial cells to anisotropic tension in the proximal-distal axis. This results in precise patterns of oriented cell elongation, cell rearrangement and cell division that elongate the blade proximo-distally and realign planar polarity with the proximal-distal axis. Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape.
[Display omitted]
► The early planar polarity pattern in Drosophila wing orients to the wing margins ► Polarity is reoriented in pupal wings by epithelial remodeling and cell flow ► Hinge contraction induces remodeling by increasing epithelial tension ► Dachsous influences polarity at both stages via effects on epithelial dynamics</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20813263</pmid><doi>10.1016/j.cell.2010.07.042</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cadherins - metabolism Cell Polarity DEVBIO Drosophila melanogaster - cytology Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Epithelium - metabolism Female Gene Expression Regulation, Developmental Pupa - cytology Wings, Animal - cytology Wings, Animal - growth & development Wings, Animal - metabolism |
| title | Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila |
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