Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis

Background & Aims Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate β-catenin in intestinal stem and progenitor c...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2010-09, Vol.139 (3), p.869-881.e9
Hauptverfasser:	Lee, Goo, Goretsky, Tatiana, Managlia, Elizabeth, Dirisina, Ramanarao, Singh, Ajay Pal, Brown, Jeffrey B, May, Randal, Yang, Guang–Yu, Ragheb, Josette William, Evers, B. Mark, Weber, Christopher R, Turner, Jerrold R, He, Xi C, Katzman, Rebecca B, Li, Linheng, Barrett, Terrence A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Biopsy Cell Proliferation Colitis - complications Colitis - enzymology Colitis - genetics Colitis - immunology Colitis - pathology Colon - drug effects Colon - enzymology Colon - immunology Colon - pathology Colonic Neoplasms - enzymology Colonic Neoplasms - pathology Colonoscopy Disease Models, Animal Gastroenterology and Hepatology Humans Interleukin-10 - deficiency Interleukin-10 - genetics Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestinal Progenitor Cells Intestinal Stem Cells Mice Mice, Inbred C57BL Mice, Knockout Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - deficiency Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation PI3K Pik3r1 Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Stem Cells - drug effects Stem Cells - enzymology Stem Cells - immunology Stem Cells - pathology T-Lymphocytes - enzymology T-Lymphocytes - immunology Time Factors Wnt Proteins - metabolism
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