Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein

► The secretion of exosomes are suppressed in Hrs-depleted dendritic cells (DCs). ► Exosomes from Hrs-depleted DCs possess attenuated antigen-presenting activity. ► Exosome secretion and DC activation are regulated by independent mechanisms. Exosomes are nanovesicles derived from multivesicular bodi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-08, Vol.399 (3), p.384-390
Hauptverfasser:	Tamai, Keiichi, Tanaka, Nobuyuki, Nakano, Takashi, Kakazu, Eiji, Kondo, Yasuteru, Inoue, Jun, Shiina, Masaaki, Fukushima, Koji, Hoshino, Tomoaki, Sano, Kouichi, Ueno, Yoshiyuki, Shimosegawa, Tooru, Sugamura, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation Cell Line Dendritic cells Dendritic Cells - immunology Endosomal Sorting Complexes Required for Transport - genetics Endosomal Sorting Complexes Required for Transport - metabolism ESCRT Exosomes Exosomes - secretion Hrs Mice Mice, Knockout Ovalbumin - immunology Phosphoproteins - genetics Phosphoproteins - metabolism
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