Congenital heart defects are under-recognised in adult patients with Down's syndrome
BackgroundCongenital heart defects (CHD) are common in patients with Down's syndrome; however, patients living in residential centres have not always been screened for CHD in the past. The aim of this study was to investigate the prevalence of CHD in patients with Down's syndrome living in...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2010-09, Vol.96 (18), p.1480-1484 |
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| creator | Vis, Jeroen C de Bruin-Bon, Rianne H Bouma, Berto J Huisman, Sylvia A Imschoot, Luc van den Brink, Kathleen Mulder, Barbara J |
| description | BackgroundCongenital heart defects (CHD) are common in patients with Down's syndrome; however, patients living in residential centres have not always been screened for CHD in the past. The aim of this study was to investigate the prevalence of CHD in patients with Down's syndrome living in residential centres, and to determine whether cardiac screening should be recommended.MethodsBetween January 2007 and November 2009 Dutch residential centres nationwide were randomly sampled. Medical files of all patients with Down's syndrome were investigated to retrieve documented information on known CHD. Echocardiography was performed on patients with unknown cardiac status. The main outcome measure was the number of newly diagnosed cases of CHD in adult patients with Down's syndrome.ResultsThirty-one centres and 1158 patients were included in the first stage of the study. Overall prevalence of known CHD was 16% (189 defects). Screening was performed in 138 patients without known CHD. In total, 24 new patients (17%) with a CHD were found, of which six patients needed semi-urgent care. Furthermore, 77% of the screened patients had mild to moderate regurgitation in one or more heart valves. Overall prevalence of CHD in adult Down's syndrome patients living in residential centres would be estimated at 33%.ConclusionsSeventeen per cent of patients with Down's syndrome living in residential centres had undiagnosed CHD, and valvular regurgitation was present in the majority of patients. Cardiac screening is recommended in older Down's syndrome patients, for whom new therapeutic options are available and for prevention of cardiac complications in old age. |
| doi_str_mv | 10.1136/hrt.2010.197509 |
| format | Article |
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The aim of this study was to investigate the prevalence of CHD in patients with Down's syndrome living in residential centres, and to determine whether cardiac screening should be recommended.MethodsBetween January 2007 and November 2009 Dutch residential centres nationwide were randomly sampled. Medical files of all patients with Down's syndrome were investigated to retrieve documented information on known CHD. Echocardiography was performed on patients with unknown cardiac status. The main outcome measure was the number of newly diagnosed cases of CHD in adult patients with Down's syndrome.ResultsThirty-one centres and 1158 patients were included in the first stage of the study. Overall prevalence of known CHD was 16% (189 defects). Screening was performed in 138 patients without known CHD. In total, 24 new patients (17%) with a CHD were found, of which six patients needed semi-urgent care. Furthermore, 77% of the screened patients had mild to moderate regurgitation in one or more heart valves. Overall prevalence of CHD in adult Down's syndrome patients living in residential centres would be estimated at 33%.ConclusionsSeventeen per cent of patients with Down's syndrome living in residential centres had undiagnosed CHD, and valvular regurgitation was present in the majority of patients. Cardiac screening is recommended in older Down's syndrome patients, for whom new therapeutic options are available and for prevention of cardiac complications in old age.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2010.197509</identifier><identifier>PMID: 20643661</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Adult ; Adults ; Age ; Alzheimer's disease ; Biological and medical sciences ; cardiac screening ; Cardiology. Vascular system ; Cardiovascular disease ; Chromosome aberrations ; Congenital diseases ; congenital heart defects ; Defects ; Down Syndrome - epidemiology ; Down's syndrome ; Epidemiologic Methods ; epidemiology ; Female ; genetics ; Guardians ; Heart ; Heart Defects, Congenital - diagnosis ; Heart Defects, Congenital - epidemiology ; Heart surgery ; Heart Valve Diseases - diagnosis ; Heart Valve Diseases - epidemiology ; Humans ; Hypertension ; Industrialized nations ; Intellectual disabilities ; Male ; Medical genetics ; Medical sciences ; Mens health ; Middle Aged ; Netherlands - epidemiology ; Population ; public health ; Residential Facilities ; Statistical analysis ; Studies ; Ultrasonic imaging ; underdiagnosis ; Women</subject><ispartof>Heart (British Cardiac Society), 2010-09, Vol.96 (18), p.1480-1484</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b468t-6f4e34567b546b41cbdfc12cc438ba8be2cef868ac901d89cde6beb56759a1903</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/96/18/1480.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/96/18/1480.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23200177$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20643661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vis, Jeroen C</creatorcontrib><creatorcontrib>de Bruin-Bon, Rianne H</creatorcontrib><creatorcontrib>Bouma, Berto J</creatorcontrib><creatorcontrib>Huisman, Sylvia A</creatorcontrib><creatorcontrib>Imschoot, Luc</creatorcontrib><creatorcontrib>van den Brink, Kathleen</creatorcontrib><creatorcontrib>Mulder, Barbara J</creatorcontrib><title>Congenital heart defects are under-recognised in adult patients with Down's syndrome</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>BackgroundCongenital heart defects (CHD) are common in patients with Down's syndrome; however, patients living in residential centres have not always been screened for CHD in the past. The aim of this study was to investigate the prevalence of CHD in patients with Down's syndrome living in residential centres, and to determine whether cardiac screening should be recommended.MethodsBetween January 2007 and November 2009 Dutch residential centres nationwide were randomly sampled. Medical files of all patients with Down's syndrome were investigated to retrieve documented information on known CHD. Echocardiography was performed on patients with unknown cardiac status. The main outcome measure was the number of newly diagnosed cases of CHD in adult patients with Down's syndrome.ResultsThirty-one centres and 1158 patients were included in the first stage of the study. Overall prevalence of known CHD was 16% (189 defects). Screening was performed in 138 patients without known CHD. In total, 24 new patients (17%) with a CHD were found, of which six patients needed semi-urgent care. Furthermore, 77% of the screened patients had mild to moderate regurgitation in one or more heart valves. Overall prevalence of CHD in adult Down's syndrome patients living in residential centres would be estimated at 33%.ConclusionsSeventeen per cent of patients with Down's syndrome living in residential centres had undiagnosed CHD, and valvular regurgitation was present in the majority of patients. Cardiac screening is recommended in older Down's syndrome patients, for whom new therapeutic options are available and for prevention of cardiac complications in old age.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>cardiac screening</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Chromosome aberrations</subject><subject>Congenital diseases</subject><subject>congenital heart defects</subject><subject>Defects</subject><subject>Down Syndrome - epidemiology</subject><subject>Down's syndrome</subject><subject>Epidemiologic Methods</subject><subject>epidemiology</subject><subject>Female</subject><subject>genetics</subject><subject>Guardians</subject><subject>Heart</subject><subject>Heart Defects, Congenital - diagnosis</subject><subject>Heart Defects, Congenital - epidemiology</subject><subject>Heart surgery</subject><subject>Heart Valve Diseases - diagnosis</subject><subject>Heart Valve Diseases - epidemiology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Industrialized nations</subject><subject>Intellectual disabilities</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Population</subject><subject>public health</subject><subject>Residential Facilities</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Ultrasonic imaging</subject><subject>underdiagnosis</subject><subject>Women</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0E1r3DAQBmBTGpo07bm3IiglUHAysmxJPpbtRwKh7SENvQlJHme1teWNJJPm31eLNynk0pOk0TPD8BbFGwqnlDJ-tg7ptILdqxUNtM-KI1pzWebSr-f5zpqm5MDEYfEyxg0A1K3kL4rDCnjNOKdHxdVq8jfoXdIDWaMOiXTYo02R6IBk9h2GMqCdbryL2BHnie7mIZGtTg59Zncurcmn6c6fRBLvfRemEV8VB70eIr7en8fFzy-fr1bn5eX3rxerj5elyUumkvc1srrhwjQ1NzW1pustraytmTRaGqws9pJLbVugnWxth9ygyQ1Nq2kL7Lg4WeZuw3Q7Y0xqdNHiMGiP0xyVaGqgDESb5bsncjPNweflFBUSBKW0oVmdLcqGKcaAvdoGN-pwryioXd4q5612easl79zxdj93NiN2j_4h4Aze74GOVg990N66-M-xCoAKkV25OBcT_nn81-G34oKJRn27XqkfQOU5XINi2X9YvBk3_93yL_lrpHo</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Vis, Jeroen C</creator><creator>de Bruin-Bon, Rianne H</creator><creator>Bouma, Berto J</creator><creator>Huisman, Sylvia A</creator><creator>Imschoot, Luc</creator><creator>van den Brink, Kathleen</creator><creator>Mulder, Barbara J</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Congenital heart defects are under-recognised in adult patients with Down's syndrome</title><author>Vis, Jeroen C ; de Bruin-Bon, Rianne H ; Bouma, Berto J ; Huisman, Sylvia A ; Imschoot, Luc ; van den Brink, Kathleen ; Mulder, Barbara J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b468t-6f4e34567b546b41cbdfc12cc438ba8be2cef868ac901d89cde6beb56759a1903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>cardiac screening</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Chromosome aberrations</topic><topic>Congenital diseases</topic><topic>congenital heart defects</topic><topic>Defects</topic><topic>Down Syndrome - epidemiology</topic><topic>Down's syndrome</topic><topic>Epidemiologic Methods</topic><topic>epidemiology</topic><topic>Female</topic><topic>genetics</topic><topic>Guardians</topic><topic>Heart</topic><topic>Heart Defects, Congenital - diagnosis</topic><topic>Heart Defects, Congenital - epidemiology</topic><topic>Heart surgery</topic><topic>Heart Valve Diseases - diagnosis</topic><topic>Heart Valve Diseases - epidemiology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Industrialized nations</topic><topic>Intellectual disabilities</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Population</topic><topic>public health</topic><topic>Residential Facilities</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Ultrasonic imaging</topic><topic>underdiagnosis</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vis, Jeroen C</creatorcontrib><creatorcontrib>de Bruin-Bon, Rianne H</creatorcontrib><creatorcontrib>Bouma, Berto J</creatorcontrib><creatorcontrib>Huisman, Sylvia A</creatorcontrib><creatorcontrib>Imschoot, Luc</creatorcontrib><creatorcontrib>van den Brink, Kathleen</creatorcontrib><creatorcontrib>Mulder, Barbara J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vis, Jeroen C</au><au>de Bruin-Bon, Rianne H</au><au>Bouma, Berto J</au><au>Huisman, Sylvia A</au><au>Imschoot, Luc</au><au>van den Brink, Kathleen</au><au>Mulder, Barbara J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congenital heart defects are under-recognised in adult patients with Down's syndrome</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>96</volume><issue>18</issue><spage>1480</spage><epage>1484</epage><pages>1480-1484</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>BackgroundCongenital heart defects (CHD) are common in patients with Down's syndrome; however, patients living in residential centres have not always been screened for CHD in the past. The aim of this study was to investigate the prevalence of CHD in patients with Down's syndrome living in residential centres, and to determine whether cardiac screening should be recommended.MethodsBetween January 2007 and November 2009 Dutch residential centres nationwide were randomly sampled. Medical files of all patients with Down's syndrome were investigated to retrieve documented information on known CHD. Echocardiography was performed on patients with unknown cardiac status. The main outcome measure was the number of newly diagnosed cases of CHD in adult patients with Down's syndrome.ResultsThirty-one centres and 1158 patients were included in the first stage of the study. Overall prevalence of known CHD was 16% (189 defects). Screening was performed in 138 patients without known CHD. In total, 24 new patients (17%) with a CHD were found, of which six patients needed semi-urgent care. Furthermore, 77% of the screened patients had mild to moderate regurgitation in one or more heart valves. Overall prevalence of CHD in adult Down's syndrome patients living in residential centres would be estimated at 33%.ConclusionsSeventeen per cent of patients with Down's syndrome living in residential centres had undiagnosed CHD, and valvular regurgitation was present in the majority of patients. Cardiac screening is recommended in older Down's syndrome patients, for whom new therapeutic options are available and for prevention of cardiac complications in old age.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>20643661</pmid><doi>10.1136/hrt.2010.197509</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adults Age Alzheimer's disease Biological and medical sciences cardiac screening Cardiology. Vascular system Cardiovascular disease Chromosome aberrations Congenital diseases congenital heart defects Defects Down Syndrome - epidemiology Down's syndrome Epidemiologic Methods epidemiology Female genetics Guardians Heart Heart Defects, Congenital - diagnosis Heart Defects, Congenital - epidemiology Heart surgery Heart Valve Diseases - diagnosis Heart Valve Diseases - epidemiology Humans Hypertension Industrialized nations Intellectual disabilities Male Medical genetics Medical sciences Mens health Middle Aged Netherlands - epidemiology Population public health Residential Facilities Statistical analysis Studies Ultrasonic imaging underdiagnosis Women |
| title | Congenital heart defects are under-recognised in adult patients with Down's syndrome |
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