Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway

Induction of apoptosis in tumor cells has become the major focus of anti-tumor therapeutics development. Juglone, a major chemical constituent of Juglans mandshurica Maxim, possesses several bioactivities including anti-tumor. Here, for the first time, we studied the molecular mechanism of Juglone-i...

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Veröffentlicht in:	European journal of pharmacology 2010-10, Vol.645 (1), p.14-22
Hauptverfasser:	Xu, Hua-Li, Yu, Xiao-Feng, Qu, Shao-Chun, Zhang, Rui, Qu, Xiang-Ru, Chen, Yan-Ping, Ma, Xing-Yuan, Sui, Da-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Inducing Factor - metabolism Biological and medical sciences Caspase Caspase Inhibitors Caspases - metabolism Cell Proliferation - drug effects Cytochromes c - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - metabolism HL-60 HL-60 Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Juglans Juglone Medical sciences Membrane Potential, Mitochondrial - drug effects Mitochondrial membrane potential Mitochondrial Proteins - metabolism Naphthoquinones - pharmacology Oligopeptides - pharmacology Pharmacology. Drug treatments Poly(ADP-ribose) Polymerases - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Messenger - metabolism
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