Comparison of weighted kappa coefficients of multiple binary diagnostic tests done on the same subjects
Sensitivity and specificity are classic parameters to assess and compare the performance of binary diagnostic tests versus a gold standard in a population. Another useful parameter to assess and compare the performance of binary tests is the weighted kappa coefficient, which is defined as a measure...
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Veröffentlicht in: | Statistics in medicine 2010-09, Vol.29 (20), p.2149-2165 |
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creator | Roldán Nofuentes, José Antonio Luna del Castillo, Juan Dios |
description | Sensitivity and specificity are classic parameters to assess and compare the performance of binary diagnostic tests versus a gold standard in a population. Another useful parameter to assess and compare the performance of binary tests is the weighted kappa coefficient, which is defined as a measure of the beyond‐chance agreement between the diagnostic test and the gold standard. In this study, we deduce the maximum likelihood estimators of the weighted kappa coefficients of multiple binary tests and we propose an asymptotic method to compare the weighted kappa coefficients of multiple binary tests with regard to the same gold standard when all of the diagnostic tests are applied to the same sample of patients. We have carried out simulation experiments to study the type I error and the power of the method that we propose when we compared three binary tests. We have applied the results obtained to the diagnosis of coronary disease. Copyright © 2010 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/sim.3939 |
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subjects | Asymptotic methods Biostatistics Cardiovascular disease Coronary Angiography - statistics & numerical data Coronary Artery Disease - diagnosis Diagnostic tests Diagnostic Tests, Routine - standards Diagnostic Tests, Routine - statistics & numerical data Electrocardiography - statistics & numerical data Exercise Test - statistics & numerical data Humans Likelihood Functions Maximum likelihood method Medical statistics Models, Statistical multiple binary diagnostic tests Patients Sensitivity and Specificity Studies weighted kappa coefficient |
title | Comparison of weighted kappa coefficients of multiple binary diagnostic tests done on the same subjects |
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