Effect of Blood Product Transfusion–Induced Tolerance on Incidence of Cardiac Allograft Rejection
Abstract Background Blood product transfusion has been successfully used in solid-organ transplantation to induce tolerance. Whether a similar protective effect of blood product transfusion exists in heart transplantation is controversial. Objective To investigate the effect of cellular blood produc...
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| Veröffentlicht in: | Transplantation proceedings 2010-09, Vol.42 (7), p.2687-2692 |
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| creator | Kotter, J.R Drakos, S.G Horne, B.D Hammond, E.H Stehlik, J Bull, D.A Reid, B.B Gilbert, E.M Everitt, M Alharethi, R Budge, D Verma, D.R Li, Y Kfoury, A.G |
| description | Abstract Background Blood product transfusion has been successfully used in solid-organ transplantation to induce tolerance. Whether a similar protective effect of blood product transfusion exists in heart transplantation is controversial. Objective To investigate the effect of cellular blood product transfusion within 2 weeks posttransplantation on the incidence of cellular and antibody-mediated rejection. Patients and Methods Patients were grouped on the basis of number of blood transfusions; group 1 received no transfusions, and groups 2, 3, and 4 each received an incremental number of transfusion units. All endomyocardial biopsy samples were routinely studied using immunofluorescence in the first 12 weeks posttransplantation. Results Baseline characteristics including age, sex, body mass index, history of diabetes, donor characteristics, and pretransplantation laboratory values were similar except that group 4 had a higher rate of previous sternotomy and longer ischemic time during transplantation. Approximately 9200 endomyocardial biopsy samples composed the data. Short- and long-term freedom from the International Society for Heart & Lung Transplantation grade 3A or higher cellular rejection and from antibody-mediated rejection were comparable between groups. Conclusions Blood transfusions within the first 2 weeks post-transplantation do not seem to confer any protective effect against posttransplantation cellular rejection or antibody- mediated rejection. Whether other unmeasured confounding factors mask their effect requires further prospective studies. |
| doi_str_mv | 10.1016/j.transproceed.2010.05.167 |
| format | Article |
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Whether a similar protective effect of blood product transfusion exists in heart transplantation is controversial. Objective To investigate the effect of cellular blood product transfusion within 2 weeks posttransplantation on the incidence of cellular and antibody-mediated rejection. Patients and Methods Patients were grouped on the basis of number of blood transfusions; group 1 received no transfusions, and groups 2, 3, and 4 each received an incremental number of transfusion units. All endomyocardial biopsy samples were routinely studied using immunofluorescence in the first 12 weeks posttransplantation. Results Baseline characteristics including age, sex, body mass index, history of diabetes, donor characteristics, and pretransplantation laboratory values were similar except that group 4 had a higher rate of previous sternotomy and longer ischemic time during transplantation. Approximately 9200 endomyocardial biopsy samples composed the data. Short- and long-term freedom from the International Society for Heart & Lung Transplantation grade 3A or higher cellular rejection and from antibody-mediated rejection were comparable between groups. Conclusions Blood transfusions within the first 2 weeks post-transplantation do not seem to confer any protective effect against posttransplantation cellular rejection or antibody- mediated rejection. Whether other unmeasured confounding factors mask their effect requires further prospective studies.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2010.05.167</identifier><identifier>PMID: 20832570</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; Blood Component Transfusion - methods ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Graft Rejection - epidemiology ; Graft Rejection - immunology ; Graft Rejection - prevention & control ; Heart Transplantation - pathology ; Heart-Lung Transplantation - pathology ; Humans ; Immune Tolerance - drug effects ; Male ; Medical sciences ; Middle Aged ; Postoperative Complications - epidemiology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Treatment Outcome</subject><ispartof>Transplantation proceedings, 2010-09, Vol.42 (7), p.2687-2692</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-f234608c35e9c9db8286f08e90d32b298acbc3db5bc779a16850d684944239f73</citedby><cites>FETCH-LOGICAL-c464t-f234608c35e9c9db8286f08e90d32b298acbc3db5bc779a16850d684944239f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134510009565$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23243443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20832570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kotter, J.R</creatorcontrib><creatorcontrib>Drakos, S.G</creatorcontrib><creatorcontrib>Horne, B.D</creatorcontrib><creatorcontrib>Hammond, E.H</creatorcontrib><creatorcontrib>Stehlik, J</creatorcontrib><creatorcontrib>Bull, D.A</creatorcontrib><creatorcontrib>Reid, B.B</creatorcontrib><creatorcontrib>Gilbert, E.M</creatorcontrib><creatorcontrib>Everitt, M</creatorcontrib><creatorcontrib>Alharethi, R</creatorcontrib><creatorcontrib>Budge, D</creatorcontrib><creatorcontrib>Verma, D.R</creatorcontrib><creatorcontrib>Li, Y</creatorcontrib><creatorcontrib>Kfoury, A.G</creatorcontrib><title>Effect of Blood Product Transfusion–Induced Tolerance on Incidence of Cardiac Allograft Rejection</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Background Blood product transfusion has been successfully used in solid-organ transplantation to induce tolerance. Whether a similar protective effect of blood product transfusion exists in heart transplantation is controversial. Objective To investigate the effect of cellular blood product transfusion within 2 weeks posttransplantation on the incidence of cellular and antibody-mediated rejection. Patients and Methods Patients were grouped on the basis of number of blood transfusions; group 1 received no transfusions, and groups 2, 3, and 4 each received an incremental number of transfusion units. All endomyocardial biopsy samples were routinely studied using immunofluorescence in the first 12 weeks posttransplantation. Results Baseline characteristics including age, sex, body mass index, history of diabetes, donor characteristics, and pretransplantation laboratory values were similar except that group 4 had a higher rate of previous sternotomy and longer ischemic time during transplantation. Approximately 9200 endomyocardial biopsy samples composed the data. Short- and long-term freedom from the International Society for Heart & Lung Transplantation grade 3A or higher cellular rejection and from antibody-mediated rejection were comparable between groups. Conclusions Blood transfusions within the first 2 weeks post-transplantation do not seem to confer any protective effect against posttransplantation cellular rejection or antibody- mediated rejection. Whether other unmeasured confounding factors mask their effect requires further prospective studies.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood Component Transfusion - methods</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>General aspects</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - prevention & control</subject><subject>Heart Transplantation - pathology</subject><subject>Heart-Lung Transplantation - pathology</subject><subject>Humans</subject><subject>Immune Tolerance - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications - epidemiology</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks2KFDEQgIMo7uzqK0gQxFOP-e9uD8I6u-rAgqLjOaTzI2l7OrtJt7A338E39EmsdmZRPHkKlfqqKnwphJ5SsqaEqhf9espmLNc5We_dmhFIELmmqr6HVrSpecUU4_fRihBBK8qFPEGnpfQEYib4Q3TCSMOZrMkK2csQvJ1wCvj1kJLDH3JyM1zslhFhLjGNP7__2I5w6R3epcFDwnqcRrwdbXT-dxDwxmQXjcXnw5C-ZBMm_NH30BnqH6EHwQzFPz6eZ-jzm8vd5l119f7tdnN-VVmhxFQFxoUijeXSt7Z1XcMaFUjjW-I461jbGNtZ7jrZ2bpuDVWNJE41ohWC8TbU_Aw9P_QFMzezL5Pex2L9MJjRp7noWgpCFG0ZkC8PpM2plOyDvs5xb_KtpkQvjnWv_3asF8eaSA2OofjJcczc7SF3V3onFYBnR8AUa4awCIvlD8fhE4TgwF0cOA9SvkWfdbFx8eliBnPapfh_73n1Txs7xDHC5K_-1pc-zXkE7ZrqwjTRn5atWJaCwj60Ukn-C_jUtuM</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Kotter, J.R</creator><creator>Drakos, S.G</creator><creator>Horne, B.D</creator><creator>Hammond, E.H</creator><creator>Stehlik, J</creator><creator>Bull, D.A</creator><creator>Reid, B.B</creator><creator>Gilbert, E.M</creator><creator>Everitt, M</creator><creator>Alharethi, R</creator><creator>Budge, D</creator><creator>Verma, D.R</creator><creator>Li, Y</creator><creator>Kfoury, A.G</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Effect of Blood Product Transfusion–Induced Tolerance on Incidence of Cardiac Allograft Rejection</title><author>Kotter, J.R ; Drakos, S.G ; Horne, B.D ; Hammond, E.H ; Stehlik, J ; Bull, D.A ; Reid, B.B ; Gilbert, E.M ; Everitt, M ; Alharethi, R ; Budge, D ; Verma, D.R ; Li, Y ; Kfoury, A.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-f234608c35e9c9db8286f08e90d32b298acbc3db5bc779a16850d684944239f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blood Component Transfusion - methods</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>General aspects</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - prevention & control</topic><topic>Heart Transplantation - pathology</topic><topic>Heart-Lung Transplantation - pathology</topic><topic>Humans</topic><topic>Immune Tolerance - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Complications - epidemiology</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kotter, J.R</creatorcontrib><creatorcontrib>Drakos, S.G</creatorcontrib><creatorcontrib>Horne, B.D</creatorcontrib><creatorcontrib>Hammond, E.H</creatorcontrib><creatorcontrib>Stehlik, J</creatorcontrib><creatorcontrib>Bull, D.A</creatorcontrib><creatorcontrib>Reid, B.B</creatorcontrib><creatorcontrib>Gilbert, E.M</creatorcontrib><creatorcontrib>Everitt, M</creatorcontrib><creatorcontrib>Alharethi, R</creatorcontrib><creatorcontrib>Budge, D</creatorcontrib><creatorcontrib>Verma, D.R</creatorcontrib><creatorcontrib>Li, Y</creatorcontrib><creatorcontrib>Kfoury, A.G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kotter, J.R</au><au>Drakos, S.G</au><au>Horne, B.D</au><au>Hammond, E.H</au><au>Stehlik, J</au><au>Bull, D.A</au><au>Reid, B.B</au><au>Gilbert, E.M</au><au>Everitt, M</au><au>Alharethi, R</au><au>Budge, D</au><au>Verma, D.R</au><au>Li, Y</au><au>Kfoury, A.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Blood Product Transfusion–Induced Tolerance on Incidence of Cardiac Allograft Rejection</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>42</volume><issue>7</issue><spage>2687</spage><epage>2692</epage><pages>2687-2692</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Background Blood product transfusion has been successfully used in solid-organ transplantation to induce tolerance. Whether a similar protective effect of blood product transfusion exists in heart transplantation is controversial. Objective To investigate the effect of cellular blood product transfusion within 2 weeks posttransplantation on the incidence of cellular and antibody-mediated rejection. Patients and Methods Patients were grouped on the basis of number of blood transfusions; group 1 received no transfusions, and groups 2, 3, and 4 each received an incremental number of transfusion units. All endomyocardial biopsy samples were routinely studied using immunofluorescence in the first 12 weeks posttransplantation. Results Baseline characteristics including age, sex, body mass index, history of diabetes, donor characteristics, and pretransplantation laboratory values were similar except that group 4 had a higher rate of previous sternotomy and longer ischemic time during transplantation. Approximately 9200 endomyocardial biopsy samples composed the data. Short- and long-term freedom from the International Society for Heart & Lung Transplantation grade 3A or higher cellular rejection and from antibody-mediated rejection were comparable between groups. Conclusions Blood transfusions within the first 2 weeks post-transplantation do not seem to confer any protective effect against posttransplantation cellular rejection or antibody- mediated rejection. Whether other unmeasured confounding factors mask their effect requires further prospective studies.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20832570</pmid><doi>10.1016/j.transproceed.2010.05.167</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Biopsy Blood Component Transfusion - methods Epidemiology Female Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Graft Rejection - epidemiology Graft Rejection - immunology Graft Rejection - prevention & control Heart Transplantation - pathology Heart-Lung Transplantation - pathology Humans Immune Tolerance - drug effects Male Medical sciences Middle Aged Postoperative Complications - epidemiology Public health. Hygiene Public health. Hygiene-occupational medicine Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Treatment Outcome |
| title | Effect of Blood Product Transfusion–Induced Tolerance on Incidence of Cardiac Allograft Rejection |
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