Substrate Selectivity of Type A and Type B Monoamine Oxidase in Rat Brain

: Use of the irreversible inhibitors clorgyline and deprenyl showed that rat brain mitochondria contain type A and type B monoamine oxidase (MAO). Tyramine is a substrate for both types of MAO, whereas serotonin is a preferential substrate for type A MAO. In contrast to MAO in other tissues, type A...

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Veröffentlicht in:	Journal of neurochemistry 1980-07, Vol.35 (1), p.109-115
Hauptverfasser:	Kinemuchi, Hiroyasu, Wakui, Yoshiko, Kamijo, Kazuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - enzymology Clorgyline Clorgyline - pharmacology Deprenyl Isoenzymes - metabolism Kinetics Male Mitochondria - drug effects Mitochondria - enzymology Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Multiple forms of MAO Rat brain mitochondrial MAO Rats Selegiline - pharmacology Substrate concentration Substrate Specificity β‐Phenylethylamine
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