Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes

Heavy marijuana use has been linked to white matter histological alterations. However, the impact of cannabis constituents on oligodendroglial pathophysiology remains poorly understood. Here, we investigated the in vitro effects of cannabidiol, the main nonpsychoactive marijuana component, on oligod...

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Veröffentlicht in:	Glia 2010-11, Vol.58 (14), p.1739-1747
Hauptverfasser:	Mato, Susana, Victoria Sánchez-Gómez, María, Matute, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals calcium Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology cannabidiol Cannabidiol - pharmacology Cannabidiol - toxicity Cells, Cultured Intracellular Fluid - drug effects Intracellular Fluid - metabolism mitochondria Neurotoxins - pharmacology Neurotoxins - toxicity oligodendrocyte Oligodendroglia - drug effects Oligodendroglia - metabolism Oligodendroglia - pathology Oxidative Stress - drug effects Oxidative Stress - physiology Rats Rats, Sprague-Dawley reactive oxygen species Up-Regulation - drug effects Up-Regulation - physiology
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