Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats

Evidence implicates oxidative stress as playing a prominent role in the pathogenesis of pulmonary hypertension, to which peroxynitrite anion (ONOO −) may make a major contribution. Hypothesizing that removal of ONOO − would attenuate chronic neonatal pulmonary hypertension, we examined the effects o...

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Veröffentlicht in:	Free radical biology & medicine 2010-11, Vol.49 (8), p.1306-1314
Hauptverfasser:	Belik, Jaques, Stevens, Danielle, Pan, Jingyi, McIntyre, Brendan A.S., Kantores, Crystal, Ivanovska, Julijana, Xu, Emily Z., Ibrahim, Christine, Panama, Brian K., Backx, Peter H., McNamara, Patrick J., Jankov, Robert P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cardiomegaly Cardiomyocyte Catalysis Cell Growth Processes - drug effects Cells, Cultured Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Echocardiography Free radicals Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Hypertension, Pulmonary - pathology Hypertension, Pulmonary - physiopathology Hypoxia - complications Hypoxia - drug therapy Hypoxia - pathology Hypoxia - physiopathology Lung - drug effects Lung - metabolism Metalloporphyrins - chemistry Metalloporphyrins - pharmacology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Neonate Nitrate Organ Culture Techniques Oxidative Stress Peroxynitrous Acid - chemistry Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary Artery - pathology Rats Smooth muscle
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