Expression of Liver X Receptors in Pregnancies Complicated by Preeclampsia
Abstract Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) α and LXRβ are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRα, LXRβ and their target genes in human term placenta, decidua and subcutaneous adi...
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| Veröffentlicht in: | Placenta (Eastbourne) 2010-09, Vol.31 (9), p.818-824 |
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| creator | Weedon-Fekjær, M.S Johnsen, G.M Anthonisen, E.H Sugulle, M Nebb, H.I Duttaroy, A.K Staff, A.C |
| description | Abstract Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) α and LXRβ are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRα, LXRβ and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRα and LXRβ in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRα, LXRβ and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRα in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRβ was reduced, and there was a positive correlation between placental LXRβ mRNA expression and placental free fatty acids in preeclampsia. Our results suggest a possible role for LXRβ as a transcriptional regulator in preeclampsia. |
| doi_str_mv | 10.1016/j.placenta.2010.06.015 |
| format | Article |
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Liver X receptor (LXR) α and LXRβ are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRα, LXRβ and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRα and LXRβ in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRα, LXRβ and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRα in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRβ was reduced, and there was a positive correlation between placental LXRβ mRNA expression and placental free fatty acids in preeclampsia. Our results suggest a possible role for LXRβ as a transcriptional regulator in preeclampsia.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2010.06.015</identifier><identifier>PMID: 20655109</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adipose tissue ; Adipose Tissue - metabolism ; Adult ; Biological and medical sciences ; CD36 ; CD36 Antigens - biosynthesis ; Decidua ; Decidua - metabolism ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Internal Medicine ; Lipids ; Liver X Receptor ; Liver X Receptors ; Obstetrics and Gynecology ; Orphan Nuclear Receptors - biosynthesis ; Placenta - metabolism ; Polyunsaturated fatty acid ; Pre-Eclampsia - metabolism ; Preeclampsia ; Pregnancy</subject><ispartof>Placenta (Eastbourne), 2010-09, Vol.31 (9), p.818-824</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-ea1555d00622d15e5fde09aeed563fd62b1018f84958cd1a9c6052ea2e076e143</citedby><cites>FETCH-LOGICAL-c518t-ea1555d00622d15e5fde09aeed563fd62b1018f84958cd1a9c6052ea2e076e143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.placenta.2010.06.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23232916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20655109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weedon-Fekjær, M.S</creatorcontrib><creatorcontrib>Johnsen, G.M</creatorcontrib><creatorcontrib>Anthonisen, E.H</creatorcontrib><creatorcontrib>Sugulle, M</creatorcontrib><creatorcontrib>Nebb, H.I</creatorcontrib><creatorcontrib>Duttaroy, A.K</creatorcontrib><creatorcontrib>Staff, A.C</creatorcontrib><title>Expression of Liver X Receptors in Pregnancies Complicated by Preeclampsia</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) α and LXRβ are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRα, LXRβ and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRα and LXRβ in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRα, LXRβ and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRα in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRβ was reduced, and there was a positive correlation between placental LXRβ mRNA expression and placental free fatty acids in preeclampsia. Our results suggest a possible role for LXRβ as a transcriptional regulator in preeclampsia.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>CD36</subject><subject>CD36 Antigens - biosynthesis</subject><subject>Decidua</subject><subject>Decidua - metabolism</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Liver X Receptor</subject><subject>Liver X Receptors</subject><subject>Obstetrics and Gynecology</subject><subject>Orphan Nuclear Receptors - biosynthesis</subject><subject>Placenta - metabolism</subject><subject>Polyunsaturated fatty acid</subject><subject>Pre-Eclampsia - metabolism</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7uzqX1j6Ip56rKQ72emLKMO6KgO7-AHeQiaplozppE31LM6_N83MKniRHALJU5XU8zJ2yWHJgatXu-UYjMU4maWAcghqCVw-YgsuG1E3HMRjtgDeNnUL0J6xc6IdAHQtF0_ZmQAlJYduwT5e_xozEvkUq9RXG3-PufpWfUKL45QyVT5Wdxm_RxOtR6rWaRiDt2ZCV20P8xXaYIaRvHnGnvQmED4_7Rfs67vrL-v39eb25sP67aa2kq-mGg2XUjoAJYTjEmXvEDqD6KRqeqfEtgy46ldtJ1fWcdNZBVKgEQhXCstEF-zlse-Y08890qQHTxZDMBHTnvSVLCML1XWFVEfS5kSUsddj9oPJB81Bzxr1Tj9o1LNGDUoXjaXw8vTEfjug-1P24K0AL06AIWtCn2c99Jdryuq4KtybI4dFyL3HrKlojBadz2gn7ZL__19e_9PCBh9LBOEHHpB2aZ9j0a25JqFBf55DnzPnJW7RFqe_AVN_p_g</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Weedon-Fekjær, M.S</creator><creator>Johnsen, G.M</creator><creator>Anthonisen, E.H</creator><creator>Sugulle, M</creator><creator>Nebb, H.I</creator><creator>Duttaroy, A.K</creator><creator>Staff, A.C</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Expression of Liver X Receptors in Pregnancies Complicated by Preeclampsia</title><author>Weedon-Fekjær, M.S ; Johnsen, G.M ; Anthonisen, E.H ; Sugulle, M ; Nebb, H.I ; Duttaroy, A.K ; Staff, A.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-ea1555d00622d15e5fde09aeed563fd62b1018f84958cd1a9c6052ea2e076e143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>CD36</topic><topic>CD36 Antigens - biosynthesis</topic><topic>Decidua</topic><topic>Decidua - metabolism</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Liver X Receptor</topic><topic>Liver X Receptors</topic><topic>Obstetrics and Gynecology</topic><topic>Orphan Nuclear Receptors - biosynthesis</topic><topic>Placenta - metabolism</topic><topic>Polyunsaturated fatty acid</topic><topic>Pre-Eclampsia - metabolism</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weedon-Fekjær, M.S</creatorcontrib><creatorcontrib>Johnsen, G.M</creatorcontrib><creatorcontrib>Anthonisen, E.H</creatorcontrib><creatorcontrib>Sugulle, M</creatorcontrib><creatorcontrib>Nebb, H.I</creatorcontrib><creatorcontrib>Duttaroy, A.K</creatorcontrib><creatorcontrib>Staff, A.C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weedon-Fekjær, M.S</au><au>Johnsen, G.M</au><au>Anthonisen, E.H</au><au>Sugulle, M</au><au>Nebb, H.I</au><au>Duttaroy, A.K</au><au>Staff, A.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Liver X Receptors in Pregnancies Complicated by Preeclampsia</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>31</volume><issue>9</issue><spage>818</spage><epage>824</epage><pages>818-824</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Abstract Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) α and LXRβ are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRα, LXRβ and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRα and LXRβ in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRα, LXRβ and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRα in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRβ was reduced, and there was a positive correlation between placental LXRβ mRNA expression and placental free fatty acids in preeclampsia. 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| subjects | Adipose tissue Adipose Tissue - metabolism Adult Biological and medical sciences CD36 CD36 Antigens - biosynthesis Decidua Decidua - metabolism Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans Internal Medicine Lipids Liver X Receptor Liver X Receptors Obstetrics and Gynecology Orphan Nuclear Receptors - biosynthesis Placenta - metabolism Polyunsaturated fatty acid Pre-Eclampsia - metabolism Preeclampsia Pregnancy |
| title | Expression of Liver X Receptors in Pregnancies Complicated by Preeclampsia |
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