Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection

Salmonella enterica serovar Typhi, the cause of typhoid fever, is host-adapted to humans and unable to cause disease in mice. Here, we show that S. Typhi can replicate in vivo in nonobese diabetic (NOD)-scid IL2rgamma(null) mice engrafted with human hematopoietic stem cells (hu-SRC-SCID mice) to cau...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-08, Vol.107 (35), p.15589-15594
Hauptverfasser:	Libby, Stephen J, Brehm, Michael A, Greiner, Dale L, Shultz, Leonard D, McClelland, Michael, Smith, Kelly D, Cookson, Brad T, Karlinsey, Joyce E, Kinkel, Traci L, Porwollik, Steffen, Canals, Rocio, Cummings, Lisa A, Fang, Ferric C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cytokines - metabolism Female Flow Cytometry Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - metabolism Humans Interferon-gamma - metabolism Interleukin Receptor Common gamma Subunit - genetics Interleukin Receptor Common gamma Subunit - metabolism Leukocyte Common Antigens - metabolism Male Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Mice, SCID Salmonella typhi - genetics Salmonella typhi - pathogenicity Tumor Necrosis Factor-alpha - metabolism Typhoid Fever - genetics Typhoid Fever - metabolism Typhoid Fever - pathology Virulence - genetics
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