Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi

▶ Six flavonoids showed antifilarial activity in vitro against Brugia malayi. ▶ Naringenin and flavone killed or sterilized adult worms in B. malayi-jird model. ▶ Only naringenin showed antifilarial activity in B. malayi- Mastomys coucha model. We evaluated the antifilarial activity of 6 flavonoids...

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Veröffentlicht in:	Acta tropica 2010-11, Vol.116 (2), p.127-133
Hauptverfasser:	Lakshmi, V., Joseph, S.K., Srivastava, S., Verma, S.K., Sahoo, M.K., Dube, V., Mishra, S.K., Murthy, P.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brugia malayi Brugia malayi - drug effects Brugia malayi - isolation & purification Coloring Agents Disease Models, Animal Diseases caused by nematodes Elephantiasis, Filarial - drug therapy Female Filariases Filaricides - pharmacology Flavanones - pharmacology Flavanones - standards Flavonoids Flavonoids - pharmacology Flavonoids - standards General aspects Gerbillinae - parasitology Helminthic diseases Hesperidin - pharmacology Humans Infectious diseases Lymphatic filariases Lymphatic filariasis Male Mastomys coucha Medical sciences Meriones unguiculatus Motility assay MTT assay Murinae - parasitology Parasitic diseases Rutin - pharmacology Survival Analysis Tetrazolium Salts Thiazoles
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