Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography

Focal adhesions are integrin-based multiprotein complexes, several micrometres in diameter, that mechanically link the extracellular matrix with the termini of actin bundles. The molecular diversity of focal adhesions and their role in cell migration and matrix sensing has been extensively studied,...

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Veröffentlicht in:	Nature cell biology 2010-09, Vol.12 (9), p.909-915
Hauptverfasser:	Grashoff, Carsten, Volberg, Tova, Elad, Nadav, Fässler, Reinhard, Hirschfeld-Warneken, Vera, Geiger, Benjamin, Spatz, Joachim P, Patla, Israel, Medalia, Ohad
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/535/1258/1260 631/45/612/1236 631/80/84/2027 Actin Cytoskeleton - metabolism Adhesion Amides - pharmacology Animals Biomedical and Life Sciences Cancer Research Cell adhesion Cell Biology Cell Line Cellular proteins Cellular signal transduction Cryoelectron Microscopy - methods Developmental Biology Extracellular matrix Fibers Fibroblasts - drug effects Fibroblasts - ultrastructure Focal Adhesions - drug effects Focal Adhesions - metabolism Focal Adhesions - ultrastructure Integrins Integrins - metabolism Kinases letter Life Sciences Membranes Microscopy Microscopy, Fluorescence Models, Molecular Particle Size Paxillin - metabolism Physiological aspects Protein Kinase Inhibitors - pharmacology Proteins Pyridines - pharmacology Rats rho-Associated Kinases - antagonists & inhibitors Stem Cells Stress Fibers - ultrastructure Tomography Tomography - methods Vinculin - metabolism
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