Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types)
Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma. A selected series of 29 cases of pleomorphic adenomas...
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| Veröffentlicht in: | Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2010-09, Vol.15 (5), p.e697-e703 |
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| container_title | Medicina oral, patología oral y cirugía bucal |
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| creator | Tarakji, Bassel Nassani, Mohammad Z |
| description | Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma.
A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
The results showed that p21 expression was negative in the most components of normal tissue of the salivary gland surrounding pleomorphic adenoma, 24 cases out of 29 of the non tumour duct cells (82.8%), and 28 (96.6%) cases out of 29 of the acinar cells shows negative p21 expression. P21 expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells. p21 was strongly expressed in carcinoma cells in 9 (33.3%) cases out of 27.
Our data suggest that the strong nuclear staining as an indicator for altered p21, then the alteration of p21 expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 33.3%). |
| doi_str_mv | 10.4317/medoral.15.e697 |
| format | Article |
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A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
The results showed that p21 expression was negative in the most components of normal tissue of the salivary gland surrounding pleomorphic adenoma, 24 cases out of 29 of the non tumour duct cells (82.8%), and 28 (96.6%) cases out of 29 of the acinar cells shows negative p21 expression. P21 expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells. p21 was strongly expressed in carcinoma cells in 9 (33.3%) cases out of 27.
Our data suggest that the strong nuclear staining as an indicator for altered p21, then the alteration of p21 expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 33.3%).</description><identifier>ISSN: 1698-6946</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.15.e697</identifier><identifier>PMID: 20383106</identifier><language>eng</language><publisher>Spain</publisher><subject>Adenocarcinoma - chemistry ; Adenocarcinoma - metabolism ; Adenoma, Pleomorphic - chemistry ; Adenoma, Pleomorphic - metabolism ; Adult ; Aged ; Aged, 80 and over ; Cyclin-Dependent Kinase Inhibitor p21 - analysis ; Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis ; Dentistry ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Salivary Gland Neoplasms - chemistry ; Salivary Gland Neoplasms - metabolism ; Salivary Glands - chemistry ; Salivary Glands - metabolism ; Young Adult</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2010-09, Vol.15 (5), p.e697-e703</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-c3eca7f03a95b6bf20540698d297fe46adcc3fd2f46614cb33e544e5d342a5ed3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20383106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tarakji, Bassel</creatorcontrib><creatorcontrib>Nassani, Mohammad Z</creatorcontrib><title>Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types)</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma.
A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
The results showed that p21 expression was negative in the most components of normal tissue of the salivary gland surrounding pleomorphic adenoma, 24 cases out of 29 of the non tumour duct cells (82.8%), and 28 (96.6%) cases out of 29 of the acinar cells shows negative p21 expression. P21 expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells. p21 was strongly expressed in carcinoma cells in 9 (33.3%) cases out of 27.
Our data suggest that the strong nuclear staining as an indicator for altered p21, then the alteration of p21 expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 33.3%).</description><subject>Adenocarcinoma - chemistry</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenoma, Pleomorphic - chemistry</subject><subject>Adenoma, Pleomorphic - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - analysis</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Salivary Gland Neoplasms - chemistry</subject><subject>Salivary Gland Neoplasms - metabolism</subject><subject>Salivary Glands - chemistry</subject><subject>Salivary Glands - metabolism</subject><subject>Young Adult</subject><issn>1698-6946</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUctOAyEUJUZja3XtzrBTE1thYJjO0hgfTUzc6HpC4WIxwzDCjKlf5S9KHz4Wbi6XnEdyz0HomJIJZ7S4dKB9kPWE5hMQZbGDhlSU07Eoudj9sw_QQYyvhLCCFmIfDTLCpowSMUSfM-f6xi9s7LxagLNK1hiWbYAYrW-wN7jNKLYNbnxwCetsjD3EFRBlbd9l-MAvtWz0BW5r8M6HdmEVlhoa7yROAFYyKLv-wfI_0visb7Q1BgI0nZUd6LVsjf5qu48W4vkh2jOyjnC0fUfo-fbm6fp-_PB4N7u-ehgrxoouTVCyMITJMp-LuclIzklKQ2dlYYALqZViRmeGC0G5mjMGOeeQa8YzmYNmI3S68W2Df0v3dpWzUUGdLgXfx6pIfinPnCfm5Yapgo8xgKnaYF2KpaKkWpVUbUuqaF6tSkqKk613P0_YD_-7FfYFlUGU9w</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Tarakji, Bassel</creator><creator>Nassani, Mohammad Z</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types)</title><author>Tarakji, Bassel ; Nassani, Mohammad Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-c3eca7f03a95b6bf20540698d297fe46adcc3fd2f46614cb33e544e5d342a5ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - chemistry</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenoma, Pleomorphic - chemistry</topic><topic>Adenoma, Pleomorphic - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - analysis</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Salivary Gland Neoplasms - chemistry</topic><topic>Salivary Gland Neoplasms - metabolism</topic><topic>Salivary Glands - chemistry</topic><topic>Salivary Glands - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tarakji, Bassel</creatorcontrib><creatorcontrib>Nassani, Mohammad Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tarakji, Bassel</au><au>Nassani, Mohammad Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types)</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>15</volume><issue>5</issue><spage>e697</spage><epage>e703</epage><pages>e697-e703</pages><issn>1698-6946</issn><eissn>1698-6946</eissn><abstract>Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma.
A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
The results showed that p21 expression was negative in the most components of normal tissue of the salivary gland surrounding pleomorphic adenoma, 24 cases out of 29 of the non tumour duct cells (82.8%), and 28 (96.6%) cases out of 29 of the acinar cells shows negative p21 expression. P21 expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells. p21 was strongly expressed in carcinoma cells in 9 (33.3%) cases out of 27.
Our data suggest that the strong nuclear staining as an indicator for altered p21, then the alteration of p21 expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 33.3%).</abstract><cop>Spain</cop><pmid>20383106</pmid><doi>10.4317/medoral.15.e697</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicina oral, patología oral y cirugía bucal, 2010-09, Vol.15 (5), p.e697-e703 |
| issn | 1698-6946 1698-6946 |
| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Adenocarcinoma - chemistry Adenocarcinoma - metabolism Adenoma, Pleomorphic - chemistry Adenoma, Pleomorphic - metabolism Adult Aged Aged, 80 and over Cyclin-Dependent Kinase Inhibitor p21 - analysis Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Dentistry Female Humans Immunohistochemistry Male Middle Aged Salivary Gland Neoplasms - chemistry Salivary Gland Neoplasms - metabolism Salivary Glands - chemistry Salivary Glands - metabolism Young Adult |
| title | Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types) |
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