An overview of the treatment of Tourette's disorder and tics

The aim of this study was to review the efficacy of various treatments for Tourette's disorder (TD) and tics. This study is a historical review of the treatment modalities prior to the advent of neuroleptics. A review of double-blind and placebo-controlled clinical trials and open studies on th...

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Veröffentlicht in:Journal of child and adolescent psychopharmacology 2010-08, Vol.20 (4), p.249-262
Hauptverfasser: Párraga, Humberto C, Harris, Kara M, Párraga, Karen L, Balen, George M, Cruz, Cristina
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container_end_page 262
container_issue 4
container_start_page 249
container_title Journal of child and adolescent psychopharmacology
container_volume 20
creator Párraga, Humberto C
Harris, Kara M
Párraga, Karen L
Balen, George M
Cruz, Cristina
description The aim of this study was to review the efficacy of various treatments for Tourette's disorder (TD) and tics. This study is a historical review of the treatment modalities prior to the advent of neuroleptics. A review of double-blind and placebo-controlled clinical trials and open studies on the use of neuroleptics and selected reports was also carried out. The literature review reveals that the treatment of TD and tics has evolved from an early history of marginally effective approaches to the advent of neuroleptics, which started a new era in TD and tic treatment, with a significantly broader range of effectiveness. Although progress has been made, the literature review nevertheless reveals a great deal of confusion as related to the clinical heterogeneity of TD and tics, differences in populations, medication-dose combinations, and outcomes. However, a role for a limited number of pharmacologic agents, combined with psychosocial approaches, has been identified. There is a need for studies in larger, diagnostically homogenous samples and for the use of more sophisticated methodology, to identify intelligible models that would allow the development of more effective treatment approaches.
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subjects Antipsychotic Agents - administration & dosage
Antipsychotic Agents - therapeutic use
Antipsychotic drugs
Care and treatment
Clinical Trials as Topic
Diagnosis
Dosage and administration
Effectiveness studies
Humans
Mental health care
Patient outcomes
Tic disorders
Tics - drug therapy
Tics - etiology
Tourette syndrome
Tourette Syndrome - drug therapy
Tourette Syndrome - physiopathology
title An overview of the treatment of Tourette's disorder and tics
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