Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes
Objective To determine whether oocyte donor FSH and age are independently associated IVF cycle success. Design Retrospective cohort study. Setting University hospital-based IVF clinic. Patient(s) Three hundred twelve donor/recipient pairs undergoing oocyte donation IVF. Main Outcome Measure(s) Numbe...
Gespeichert in:
| Veröffentlicht in: | Fertility and sterility 2010-09, Vol.94 (4), p.1292-1295 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1295 |
|---|---|
| container_issue | 4 |
| container_start_page | 1292 |
| container_title | Fertility and sterility |
| container_volume | 94 |
| creator | Barton, Sara E., M.D Missmer, Stacey A., Sc.D Ashby, Rachel K., M.D Ginsburg, Elizabeth S., M.D |
| description | Objective To determine whether oocyte donor FSH and age are independently associated IVF cycle success. Design Retrospective cohort study. Setting University hospital-based IVF clinic. Patient(s) Three hundred twelve donor/recipient pairs undergoing oocyte donation IVF. Main Outcome Measure(s) Number of mature oocytes and embryos, clinical pregnancy, and live birth rates. Result(s) Donors' basal FSH levels were not associated with IVF cycle outcomes. However, for every year increase in donor age, the number of mature oocytes decreased by 0.39 and the number of embryos decreased by 0.25 resulting in 1 less embryo for each 4-year increase in age, even in young donors. For every 100 pg/mL increase in estradiol on the day of hCG administration, the number of mature oocytes increased by 0.49 and the number of embryos increased by 0.36. For each additional 75 IU of gonadotropin used during stimulation, the likelihood of pregnancy and live birth decreased by 3.5%. Conclusion(s) Donor oocyte IVF cycle outcomes were not associated with donor basal FSH. However, donor age and estradiol level on the day of hCG administration were significantly associated with numbers of mature oocytes and embryos obtained, and the amount of gonadotropin used in the stimulation was significantly associated with the likelihood of pregnancy and live birth. |
| doi_str_mv | 10.1016/j.fertnstert.2009.07.1672 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_753997801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028209034657</els_id><sourcerecordid>753997801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c512t-7b03aea5ea3d20684b05d103735885c722f660100bbbca1a5e5e1c4954e9277e3</originalsourceid><addsrcrecordid>eNqNksFu1DAQhiMEoqXwCsgcECB1l7GzjpMLElqxtFIRhwJXy3EmXS-OXTxJ0T4Ob4rDrqjEiYvt0Xzzz8j_FMULDksOvHq7W_aYxkBjPpcCoFmCWvJKiQfFKZeyWshKlg-LUwAuFyBqcVI8IdoBQMWVeFyc8KbmzaqUp8WvT5Mf3Z1JzozITDB-T45Y7Nm4zTFRtDnjYmAtjj8RA4vR7jPaxRATs1uTjM1zOBqdpXPmgvVT58INaw0Zz_rovbMeWc4Pk89SObWNaYgB2evN9cWb3LRj5gbP_zwuv22Y3c8FcRptHJCeFo964wmfHe-z4uvmw5f1xeLq88fL9furhZVcjAvVQmnQSDRlJ6CqVy3IjkOpSlnX0ioh-qoCDtC2rTU8gxK5XTVyhY1QCsuz4tVB9zbFHxPSqAdHFr03AeNEWsmyaVQNPJPNgbQpEiXs9W1yg0l7zUHPBumdvjdIzwZpUHo2KNc-P3aZ2gG7-8qjIxl4eQQMWeP7ZIJ19JcTJW8yqjK3PnCY_-TOYdJkHQaLnUtoR91F91_jvPtHxXoXXG78HfdIuzilvBKkuSahQV_PGzUvFDRQriqpyt8_Xcwk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>753997801</pqid></control><display><type>article</type><title>Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Barton, Sara E., M.D ; Missmer, Stacey A., Sc.D ; Ashby, Rachel K., M.D ; Ginsburg, Elizabeth S., M.D</creator><creatorcontrib>Barton, Sara E., M.D ; Missmer, Stacey A., Sc.D ; Ashby, Rachel K., M.D ; Ginsburg, Elizabeth S., M.D</creatorcontrib><description>Objective To determine whether oocyte donor FSH and age are independently associated IVF cycle success. Design Retrospective cohort study. Setting University hospital-based IVF clinic. Patient(s) Three hundred twelve donor/recipient pairs undergoing oocyte donation IVF. Main Outcome Measure(s) Number of mature oocytes and embryos, clinical pregnancy, and live birth rates. Result(s) Donors' basal FSH levels were not associated with IVF cycle outcomes. However, for every year increase in donor age, the number of mature oocytes decreased by 0.39 and the number of embryos decreased by 0.25 resulting in 1 less embryo for each 4-year increase in age, even in young donors. For every 100 pg/mL increase in estradiol on the day of hCG administration, the number of mature oocytes increased by 0.49 and the number of embryos increased by 0.36. For each additional 75 IU of gonadotropin used during stimulation, the likelihood of pregnancy and live birth decreased by 3.5%. Conclusion(s) Donor oocyte IVF cycle outcomes were not associated with donor basal FSH. However, donor age and estradiol level on the day of hCG administration were significantly associated with numbers of mature oocytes and embryos obtained, and the amount of gonadotropin used in the stimulation was significantly associated with the likelihood of pregnancy and live birth.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2009.07.1672</identifier><identifier>PMID: 19819435</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Biological and medical sciences ; Birth control ; Chorionic Gonadotropin - administration & dosage ; donor age ; donor FSH ; Dose-Response Relationship, Drug ; egg donation ; Estradiol - blood ; Female ; Fertility Agents, Female - administration & dosage ; Fertilization in Vitro ; Follicle Stimulating Hormone - blood ; Gynecology. Andrology. Obstetrics ; Humans ; Internal Medicine ; Medical sciences ; Multivariate Analysis ; Obstetrics and Gynecology ; Oocyte donation ; Oocyte Donation - methods ; Ovulation - blood ; Ovulation Induction - methods ; Pregnancy ; Pregnancy Rate ; Sterility. Assisted procreation ; Tissue Donors ; Treatment Outcome ; Young Adult</subject><ispartof>Fertility and sterility, 2010-09, Vol.94 (4), p.1292-1295</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2010 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-7b03aea5ea3d20684b05d103735885c722f660100bbbca1a5e5e1c4954e9277e3</citedby><cites>FETCH-LOGICAL-c512t-7b03aea5ea3d20684b05d103735885c722f660100bbbca1a5e5e1c4954e9277e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2009.07.1672$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23199817$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19819435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barton, Sara E., M.D</creatorcontrib><creatorcontrib>Missmer, Stacey A., Sc.D</creatorcontrib><creatorcontrib>Ashby, Rachel K., M.D</creatorcontrib><creatorcontrib>Ginsburg, Elizabeth S., M.D</creatorcontrib><title>Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To determine whether oocyte donor FSH and age are independently associated IVF cycle success. Design Retrospective cohort study. Setting University hospital-based IVF clinic. Patient(s) Three hundred twelve donor/recipient pairs undergoing oocyte donation IVF. Main Outcome Measure(s) Number of mature oocytes and embryos, clinical pregnancy, and live birth rates. Result(s) Donors' basal FSH levels were not associated with IVF cycle outcomes. However, for every year increase in donor age, the number of mature oocytes decreased by 0.39 and the number of embryos decreased by 0.25 resulting in 1 less embryo for each 4-year increase in age, even in young donors. For every 100 pg/mL increase in estradiol on the day of hCG administration, the number of mature oocytes increased by 0.49 and the number of embryos increased by 0.36. For each additional 75 IU of gonadotropin used during stimulation, the likelihood of pregnancy and live birth decreased by 3.5%. Conclusion(s) Donor oocyte IVF cycle outcomes were not associated with donor basal FSH. However, donor age and estradiol level on the day of hCG administration were significantly associated with numbers of mature oocytes and embryos obtained, and the amount of gonadotropin used in the stimulation was significantly associated with the likelihood of pregnancy and live birth.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>donor age</subject><subject>donor FSH</subject><subject>Dose-Response Relationship, Drug</subject><subject>egg donation</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Fertilization in Vitro</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Obstetrics and Gynecology</subject><subject>Oocyte donation</subject><subject>Oocyte Donation - methods</subject><subject>Ovulation - blood</subject><subject>Ovulation Induction - methods</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Sterility. Assisted procreation</subject><subject>Tissue Donors</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEoqXwCsgcECB1l7GzjpMLElqxtFIRhwJXy3EmXS-OXTxJ0T4Ob4rDrqjEiYvt0Xzzz8j_FMULDksOvHq7W_aYxkBjPpcCoFmCWvJKiQfFKZeyWshKlg-LUwAuFyBqcVI8IdoBQMWVeFyc8KbmzaqUp8WvT5Mf3Z1JzozITDB-T45Y7Nm4zTFRtDnjYmAtjj8RA4vR7jPaxRATs1uTjM1zOBqdpXPmgvVT58INaw0Zz_rovbMeWc4Pk89SObWNaYgB2evN9cWb3LRj5gbP_zwuv22Y3c8FcRptHJCeFo964wmfHe-z4uvmw5f1xeLq88fL9furhZVcjAvVQmnQSDRlJ6CqVy3IjkOpSlnX0ioh-qoCDtC2rTU8gxK5XTVyhY1QCsuz4tVB9zbFHxPSqAdHFr03AeNEWsmyaVQNPJPNgbQpEiXs9W1yg0l7zUHPBumdvjdIzwZpUHo2KNc-P3aZ2gG7-8qjIxl4eQQMWeP7ZIJ19JcTJW8yqjK3PnCY_-TOYdJkHQaLnUtoR91F91_jvPtHxXoXXG78HfdIuzilvBKkuSahQV_PGzUvFDRQriqpyt8_Xcwk</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Barton, Sara E., M.D</creator><creator>Missmer, Stacey A., Sc.D</creator><creator>Ashby, Rachel K., M.D</creator><creator>Ginsburg, Elizabeth S., M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes</title><author>Barton, Sara E., M.D ; Missmer, Stacey A., Sc.D ; Ashby, Rachel K., M.D ; Ginsburg, Elizabeth S., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-7b03aea5ea3d20684b05d103735885c722f660100bbbca1a5e5e1c4954e9277e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>donor age</topic><topic>donor FSH</topic><topic>Dose-Response Relationship, Drug</topic><topic>egg donation</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Fertilization in Vitro</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Obstetrics and Gynecology</topic><topic>Oocyte donation</topic><topic>Oocyte Donation - methods</topic><topic>Ovulation - blood</topic><topic>Ovulation Induction - methods</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Sterility. Assisted procreation</topic><topic>Tissue Donors</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barton, Sara E., M.D</creatorcontrib><creatorcontrib>Missmer, Stacey A., Sc.D</creatorcontrib><creatorcontrib>Ashby, Rachel K., M.D</creatorcontrib><creatorcontrib>Ginsburg, Elizabeth S., M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barton, Sara E., M.D</au><au>Missmer, Stacey A., Sc.D</au><au>Ashby, Rachel K., M.D</au><au>Ginsburg, Elizabeth S., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>94</volume><issue>4</issue><spage>1292</spage><epage>1295</epage><pages>1292-1295</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To determine whether oocyte donor FSH and age are independently associated IVF cycle success. Design Retrospective cohort study. Setting University hospital-based IVF clinic. Patient(s) Three hundred twelve donor/recipient pairs undergoing oocyte donation IVF. Main Outcome Measure(s) Number of mature oocytes and embryos, clinical pregnancy, and live birth rates. Result(s) Donors' basal FSH levels were not associated with IVF cycle outcomes. However, for every year increase in donor age, the number of mature oocytes decreased by 0.39 and the number of embryos decreased by 0.25 resulting in 1 less embryo for each 4-year increase in age, even in young donors. For every 100 pg/mL increase in estradiol on the day of hCG administration, the number of mature oocytes increased by 0.49 and the number of embryos increased by 0.36. For each additional 75 IU of gonadotropin used during stimulation, the likelihood of pregnancy and live birth decreased by 3.5%. Conclusion(s) Donor oocyte IVF cycle outcomes were not associated with donor basal FSH. However, donor age and estradiol level on the day of hCG administration were significantly associated with numbers of mature oocytes and embryos obtained, and the amount of gonadotropin used in the stimulation was significantly associated with the likelihood of pregnancy and live birth.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19819435</pmid><doi>10.1016/j.fertnstert.2009.07.1672</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 2010-09, Vol.94 (4), p.1292-1295 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_753997801 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Biological and medical sciences Birth control Chorionic Gonadotropin - administration & dosage donor age donor FSH Dose-Response Relationship, Drug egg donation Estradiol - blood Female Fertility Agents, Female - administration & dosage Fertilization in Vitro Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Humans Internal Medicine Medical sciences Multivariate Analysis Obstetrics and Gynecology Oocyte donation Oocyte Donation - methods Ovulation - blood Ovulation Induction - methods Pregnancy Pregnancy Rate Sterility. Assisted procreation Tissue Donors Treatment Outcome Young Adult |
| title | Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T07%3A05%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multivariate%20analysis%20of%20the%20association%20between%20oocyte%20donor%20characteristics,%20including%20basal%20follicle%20stimulating%20hormone%20(FSH)%20and%20age,%20and%20IVF%20cycle%20outcomes&rft.jtitle=Fertility%20and%20sterility&rft.au=Barton,%20Sara%20E.,%20M.D&rft.date=2010-09-01&rft.volume=94&rft.issue=4&rft.spage=1292&rft.epage=1295&rft.pages=1292-1295&rft.issn=0015-0282&rft.eissn=1556-5653&rft.coden=FESTAS&rft_id=info:doi/10.1016/j.fertnstert.2009.07.1672&rft_dat=%3Cproquest_cross%3E753997801%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=753997801&rft_id=info:pmid/19819435&rft_els_id=S0015028209034657&rfr_iscdi=true |