Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria

This report illustrates a new strategy in designing antibacterial agentsa series of commercially available compounds, amino-substituted pyrimidines (themselves completely inactive as antibiotics), when presented on gold nanoparticles (NPs), show antibacterial activities against multidrug-resistant...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-09, Vol.132 (35), p.12349-12356
Hauptverfasser:	Zhao, Yuyun, Tian, Yue, Cui, Yan, Liu, Wenwen, Ma, Wanshun, Jiang, Xingyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Cell Membrane - drug effects Gold - chemistry Gold - pharmacology Gram-Negative Bacteria - cytology Gram-Negative Bacteria - drug effects Metal Nanoparticles - chemistry Microbial Sensitivity Tests Molecular Weight Organogold Compounds - chemical synthesis Organogold Compounds - chemistry Organogold Compounds - pharmacology Particle Size Pyrimidines - chemistry Surface Properties
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