Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria
This report illustrates a new strategy in designing antibacterial agentsa series of commercially available compounds, amino-substituted pyrimidines (themselves completely inactive as antibiotics), when presented on gold nanoparticles (NPs), show antibacterial activities against multidrug-resistant...
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| Veröffentlicht in: | Journal of the American Chemical Society 2010-09, Vol.132 (35), p.12349-12356 |
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| container_end_page | 12356 |
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| container_issue | 35 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 132 |
| creator | Zhao, Yuyun Tian, Yue Cui, Yan Liu, Wenwen Ma, Wanshun Jiang, Xingyu |
| description | This report illustrates a new strategy in designing antibacterial agentsa series of commercially available compounds, amino-substituted pyrimidines (themselves completely inactive as antibiotics), when presented on gold nanoparticles (NPs), show antibacterial activities against multidrug-resistant clinical isolates, without external sources of energy such as IR. These pyrimidine-capped gold NPs exert their antibiotic actions via sequestration of magnesium or calcium ions to disrupt the bacterial cell membrane, resulting in leakage of cytoplasmic contents including nucleic acids from compromised cell membranes, and via interaction with DNA and inhibition of protein synthesis by internalized NPs. These amino-substituted pyrimidine-capped gold NPs induce bacterial resistance more slowly compared with conventional, small-molecule antibiotics and appear harmless to human cells; these NPs may hence be useful for clinical applications. |
| doi_str_mv | 10.1021/ja1028843 |
| format | Article |
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These pyrimidine-capped gold NPs exert their antibiotic actions via sequestration of magnesium or calcium ions to disrupt the bacterial cell membrane, resulting in leakage of cytoplasmic contents including nucleic acids from compromised cell membranes, and via interaction with DNA and inhibition of protein synthesis by internalized NPs. 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These amino-substituted pyrimidine-capped gold NPs induce bacterial resistance more slowly compared with conventional, small-molecule antibiotics and appear harmless to human cells; these NPs may hence be useful for clinical applications.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - antagonists & inhibitors</subject><subject>Bacterial Proteins - metabolism</subject><subject>Cell Membrane - drug effects</subject><subject>Gold - chemistry</subject><subject>Gold - pharmacology</subject><subject>Gram-Negative Bacteria - cytology</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Weight</subject><subject>Organogold Compounds - chemical synthesis</subject><subject>Organogold Compounds - chemistry</subject><subject>Organogold Compounds - pharmacology</subject><subject>Particle Size</subject><subject>Pyrimidines - chemistry</subject><subject>Surface Properties</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtOwzAQRS0EgvJY8APIG4RYBMZ2E7vLUkFBKg-Jso4myaSkch7YDhJ_T1ALK1ZXMzq6mjmMnQq4EiDF9RqHMGasdthIxBKiWMhkl40AQEbaJOqAHXq_HsaxNGKfHUjQoFUMI7Z-rdFa_thayntL0Qy7jgo-b23Bn7BpO3Shyi15jp6_tIGawKdNqDLMA7kKLZ-uhp3ny3cMfIluRYHPHdbRE60wVJ_Eb7boMdsr0Xo62eYRe7u7Xc7uo8Xz_GE2XUSoxDhEOlcyyRMhSBTDmRMFCKSzuJDlRGqRESQZGCN1RkoUJhkLMkUJRRKbjEoo1RG72PR2rv3oyYe0rnxO1mJDbe9THavJRGtIBvJyQ-au9d5RmXauqtF9pQLSH7Ppn9mBPdu29llNxR_5q3IAzjcA5j5dt71rhif_KfoGPdx-iQ</recordid><startdate>20100908</startdate><enddate>20100908</enddate><creator>Zhao, Yuyun</creator><creator>Tian, Yue</creator><creator>Cui, Yan</creator><creator>Liu, Wenwen</creator><creator>Ma, Wanshun</creator><creator>Jiang, Xingyu</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100908</creationdate><title>Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria</title><author>Zhao, Yuyun ; Tian, Yue ; Cui, Yan ; Liu, Wenwen ; Ma, Wanshun ; Jiang, Xingyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a314t-7c326c611e1d070930a0e7b5d2f9271be06b08827be31d8641e8df0d658bef0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Proteins - antagonists & inhibitors</topic><topic>Bacterial Proteins - metabolism</topic><topic>Cell Membrane - drug effects</topic><topic>Gold - chemistry</topic><topic>Gold - pharmacology</topic><topic>Gram-Negative Bacteria - cytology</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Weight</topic><topic>Organogold Compounds - chemical synthesis</topic><topic>Organogold Compounds - chemistry</topic><topic>Organogold Compounds - pharmacology</topic><topic>Particle Size</topic><topic>Pyrimidines - chemistry</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yuyun</creatorcontrib><creatorcontrib>Tian, Yue</creatorcontrib><creatorcontrib>Cui, Yan</creatorcontrib><creatorcontrib>Liu, Wenwen</creatorcontrib><creatorcontrib>Ma, Wanshun</creatorcontrib><creatorcontrib>Jiang, Xingyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yuyun</au><au>Tian, Yue</au><au>Cui, Yan</au><au>Liu, Wenwen</au><au>Ma, Wanshun</au><au>Jiang, Xingyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2010-09-08</date><risdate>2010</risdate><volume>132</volume><issue>35</issue><spage>12349</spage><epage>12356</epage><pages>12349-12356</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>This report illustrates a new strategy in designing antibacterial agentsa series of commercially available compounds, amino-substituted pyrimidines (themselves completely inactive as antibiotics), when presented on gold nanoparticles (NPs), show antibacterial activities against multidrug-resistant clinical isolates, without external sources of energy such as IR. These pyrimidine-capped gold NPs exert their antibiotic actions via sequestration of magnesium or calcium ions to disrupt the bacterial cell membrane, resulting in leakage of cytoplasmic contents including nucleic acids from compromised cell membranes, and via interaction with DNA and inhibition of protein synthesis by internalized NPs. 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| source | MEDLINE; American Chemical Society Journals |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Cell Membrane - drug effects Gold - chemistry Gold - pharmacology Gram-Negative Bacteria - cytology Gram-Negative Bacteria - drug effects Metal Nanoparticles - chemistry Microbial Sensitivity Tests Molecular Weight Organogold Compounds - chemical synthesis Organogold Compounds - chemistry Organogold Compounds - pharmacology Particle Size Pyrimidines - chemistry Surface Properties |
| title | Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria |
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