Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression

Background Genome-wide association studies are a powerful tool for unravelling the genetic background of complex disorders such as major depression. Methods We conducted a genome-wide association study of 604 patients with major depression and 1364 population based control subjects. The top hundred...

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Veröffentlicht in:	Biological psychiatry (1969) 2010-09, Vol.68 (6), p.578-585
Hauptverfasser:	Rietschel, Marcella, Mattheisen, Manuel, Frank, Josef, Treutlein, Jens, Degenhardt, Franziska, Breuer, René, Steffens, Michael, Mier, Daniela, Esslinger, Christine, Walter, Henrik, Kirsch, Peter, Erk, Susanne, Schnell, Knut, Herms, Stefan, Wichmann, H.-Erich, Schreiber, Stefan, Jöckel, Karl-Heinz, Strohmaier, Jana, Roeske, Darina, Haenisch, Britta, Gross, Magdalena, Hoefels, Susanne, Lucae, Susanne, Binder, Elisabeth B, Wienker, Thomas F, Schulze, Thomas G, Schmäl, Christine, Zimmer, Andreas, Juraeva, Dilafruz, Brors, Benedikt, Bettecken, Thomas, Meyer-Lindenberg, Andreas, Müller-Myhsok, Bertram, Maier, Wolfgang, Nöthen, Markus M, Cichon, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Biological and medical sciences Brain - physiopathology Carboxypeptidase M Carrier Proteins - genetics Carrier Proteins - physiology CPM Depression Depressive Disorder, Major - genetics Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Female gene-wide Genome-Wide Association Study - methods Homer Scaffolding Proteins HOMER1 Humans Magnetic Resonance Imaging major depression Male Medical sciences Middle Aged Mood disorders neuroimaging Psychiatry Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - physiology Psychopathology. Psychiatry
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