Preparation of novel β-cyclodextrin functionalized monolith and its application in chiral separation
A novel β-cyclodextrin (β-CD) functionalized organic polymer monolith was prepared by covalently bonding ethylenediamine-β-CD (EDA-β-CD) to poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) monolith via ring opening reaction of epoxy groups. SEM characterization was...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2010-09, Vol.878 (26), p.2461-2464 |
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| container_issue | 26 |
| container_start_page | 2461 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Lv, Yongqin Mei, Danping Pan, Xinxin Tan, Tianwei |
| description | A novel β-cyclodextrin (β-CD) functionalized organic polymer monolith was prepared by covalently bonding ethylenediamine-β-CD (EDA-β-CD) to poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) monolith via ring opening reaction of epoxy groups. SEM characterization was performed to confirm the homogeneity of the monolithic polymer. The resulting monolith was then characterized by DSC and XPS elemental analysis to study the thermal stability of the monolith, and to prove the successful immobilization of β-CD on the polymer substrate. The β-CD ligand density of 0.68
mmol
g
−1 was obtained for the modified monolith, indicating the high reactivity and efficiency of the EDA-β-CD modifier. The ethylenediamine-β-CD functionalized monoliths were used for the chiral separation of ibuprofen racemic mixture and showed promising results. |
| doi_str_mv | 10.1016/j.jchromb.2010.07.020 |
| format | Article |
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mmol
g
−1 was obtained for the modified monolith, indicating the high reactivity and efficiency of the EDA-β-CD modifier. The ethylenediamine-β-CD functionalized monoliths were used for the chiral separation of ibuprofen racemic mixture and showed promising results.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2010.07.020</identifier><identifier>PMID: 20724232</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; beta-Cyclodextrins - chemistry ; Biological and medical sciences ; Calorimetry, Differential Scanning ; Chiral separation ; Chromatography, High Pressure Liquid - methods ; Ethylamines - chemistry ; Ethylene Glycols ; Ethylenediamine-β-CD ; Ethylenediamines - chemistry ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Ibuprofen ; Ibuprofen - chemistry ; Medical sciences ; Methacrylates - chemistry ; Methanol - chemistry ; Microscopy, Electron, Scanning ; Pharmacology. Drug treatments ; Photoelectron Spectroscopy ; Poly(GMA-co-EGDMA) ; Stereoisomerism</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-09, Vol.878 (26), p.2461-2464</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-d054f546492d767af5428c135faaf8fe1ab315a783d5fa79480de8f35bba74693</citedby><cites>FETCH-LOGICAL-c423t-d054f546492d767af5428c135faaf8fe1ab315a783d5fa79480de8f35bba74693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchromb.2010.07.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23243005$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20724232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lv, Yongqin</creatorcontrib><creatorcontrib>Mei, Danping</creatorcontrib><creatorcontrib>Pan, Xinxin</creatorcontrib><creatorcontrib>Tan, Tianwei</creatorcontrib><title>Preparation of novel β-cyclodextrin functionalized monolith and its application in chiral separation</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>A novel β-cyclodextrin (β-CD) functionalized organic polymer monolith was prepared by covalently bonding ethylenediamine-β-CD (EDA-β-CD) to poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) monolith via ring opening reaction of epoxy groups. SEM characterization was performed to confirm the homogeneity of the monolithic polymer. The resulting monolith was then characterized by DSC and XPS elemental analysis to study the thermal stability of the monolith, and to prove the successful immobilization of β-CD on the polymer substrate. The β-CD ligand density of 0.68
mmol
g
−1 was obtained for the modified monolith, indicating the high reactivity and efficiency of the EDA-β-CD modifier. The ethylenediamine-β-CD functionalized monoliths were used for the chiral separation of ibuprofen racemic mixture and showed promising results.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>beta-Cyclodextrins - chemistry</subject><subject>Biological and medical sciences</subject><subject>Calorimetry, Differential Scanning</subject><subject>Chiral separation</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Ethylamines - chemistry</subject><subject>Ethylene Glycols</subject><subject>Ethylenediamine-β-CD</subject><subject>Ethylenediamines - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Ibuprofen</subject><subject>Ibuprofen - chemistry</subject><subject>Medical sciences</subject><subject>Methacrylates - chemistry</subject><subject>Methanol - chemistry</subject><subject>Microscopy, Electron, Scanning</subject><subject>Pharmacology. Drug treatments</subject><subject>Photoelectron Spectroscopy</subject><subject>Poly(GMA-co-EGDMA)</subject><subject>Stereoisomerism</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMuKFDEUhgtRnIs-gpKNuKr2JKlUqlYig47CgC4U3IVTudBpUkmZVA8zPpYP4jOZpttx6SqHn-_8OXxN84LChgLt3-w2O73NaZ42DGoGcgMMHjXndJC85bL__rjOQkILjLOz5qKUHQCVIPnT5oyBZF3Nzxv7JdsFM64-RZIcienWBvL7V6vvdUjG3q3ZR-L2UR8IDP6nNWROMQW_bglGQ_xaCC5L8PpYUnG99RkDKQ_Nz5onDkOxz0_vZfPtw_uvVx_bm8_Xn67e3bS6XrO2BkTnRNd3IzOyl1hnNmjKhUN0g7MUJ04FyoGbGsmxG8DYwXExTSi7fuSXzetj75LTj70tq5p90TYEjDbti5KCj2NPaV9JcSR1TqVk69SS_Yz5XlFQB8Fqp06C1UGwAqmq4Lr38vTDfpqtedj6a7QCr04AFo3BZYzal38cZx0HEJV7e-Rs9XHrbVZFexu1NT5bvSqT_H9O-QNBm56F</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Lv, Yongqin</creator><creator>Mei, Danping</creator><creator>Pan, Xinxin</creator><creator>Tan, Tianwei</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100915</creationdate><title>Preparation of novel β-cyclodextrin functionalized monolith and its application in chiral separation</title><author>Lv, Yongqin ; Mei, Danping ; Pan, Xinxin ; Tan, Tianwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d054f546492d767af5428c135faaf8fe1ab315a783d5fa79480de8f35bba74693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>beta-Cyclodextrins - chemistry</topic><topic>Biological and medical sciences</topic><topic>Calorimetry, Differential Scanning</topic><topic>Chiral separation</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Ethylamines - chemistry</topic><topic>Ethylene Glycols</topic><topic>Ethylenediamine-β-CD</topic><topic>Ethylenediamines - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Ibuprofen</topic><topic>Ibuprofen - chemistry</topic><topic>Medical sciences</topic><topic>Methacrylates - chemistry</topic><topic>Methanol - chemistry</topic><topic>Microscopy, Electron, Scanning</topic><topic>Pharmacology. Drug treatments</topic><topic>Photoelectron Spectroscopy</topic><topic>Poly(GMA-co-EGDMA)</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lv, Yongqin</creatorcontrib><creatorcontrib>Mei, Danping</creatorcontrib><creatorcontrib>Pan, Xinxin</creatorcontrib><creatorcontrib>Tan, Tianwei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2010-09-15</date><risdate>2010</risdate><volume>878</volume><issue>26</issue><spage>2461</spage><epage>2464</epage><pages>2461-2464</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>A novel β-cyclodextrin (β-CD) functionalized organic polymer monolith was prepared by covalently bonding ethylenediamine-β-CD (EDA-β-CD) to poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) monolith via ring opening reaction of epoxy groups. SEM characterization was performed to confirm the homogeneity of the monolithic polymer. The resulting monolith was then characterized by DSC and XPS elemental analysis to study the thermal stability of the monolith, and to prove the successful immobilization of β-CD on the polymer substrate. The β-CD ligand density of 0.68
mmol
g
−1 was obtained for the modified monolith, indicating the high reactivity and efficiency of the EDA-β-CD modifier. The ethylenediamine-β-CD functionalized monoliths were used for the chiral separation of ibuprofen racemic mixture and showed promising results.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20724232</pmid><doi>10.1016/j.jchromb.2010.07.020</doi><tpages>4</tpages></addata></record> |
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| subjects | Analysis Analytical, structural and metabolic biochemistry beta-Cyclodextrins - chemistry Biological and medical sciences Calorimetry, Differential Scanning Chiral separation Chromatography, High Pressure Liquid - methods Ethylamines - chemistry Ethylene Glycols Ethylenediamine-β-CD Ethylenediamines - chemistry Fundamental and applied biological sciences. Psychology General pharmacology Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Ibuprofen Ibuprofen - chemistry Medical sciences Methacrylates - chemistry Methanol - chemistry Microscopy, Electron, Scanning Pharmacology. Drug treatments Photoelectron Spectroscopy Poly(GMA-co-EGDMA) Stereoisomerism |
| title | Preparation of novel β-cyclodextrin functionalized monolith and its application in chiral separation |
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