Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice

Abstract Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), which play pivotal roles in atherogenesis, have been reported to be involved in plaque stability. Licofelone, a dual COX and 5-LOX inhibitor, has been reported to possess anti-atherogenic effect in rabbit atherosclerosis model. We therefore i...

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Veröffentlicht in:	Atherosclerosis 2010-09, Vol.212 (1), p.146-152
Hauptverfasser:	Choi, Jae-Hoon, Jeon, Hyung Jun, Park, Jong-Gil, Sonn, Seong Keun, Lee, Mi-Ran, Lee, Mi-Ni, You, Hye Jin, Kim, Geun-Young, Kim, Jae-Hong, Lee, Mun Han, Kwon, Oh-Seung, Nam, Ki-Hoan, Kim, Hyoung-Chin, Jeong, Tae-Sook, Lee, Woo Song, Oh, Goo Taeg
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase Animals Aorta, Thoracic - drug effects Aorta, Thoracic - enzymology Aorta, Thoracic - pathology Aortic Diseases - enzymology Aortic Diseases - genetics Aortic Diseases - pathology Aortic Diseases - prevention & control Arachidonate 5-Lipoxygenase - metabolism Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - enzymology Atherosclerosis - genetics Atherosclerosis - prevention & control BHB-TZD Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cholesterol - blood Cyclooxygenase Cyclooxygenase Inhibitors - pharmacology Dinoprostone - blood Disease Models, Animal Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects General aspects Hyperlipidemias - drug therapy Hyperlipidemias - enzymology Hyperlipidemias - genetics Inflammation Mediators - metabolism Leukotriene B4 - blood Lipoproteins, HDL - blood Lipoxygenase Inhibitors - pharmacology Macrophages - drug effects Macrophages - enzymology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - enzymology Prostaglandin-Endoperoxide Synthases - metabolism Receptors, LDL - deficiency Receptors, LDL - genetics RNA, Messenger - metabolism Thiazolidinediones - pharmacology Time Factors Triglycerides - blood Vertebrates: cardiovascular system
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