Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a Potential Peripheral Cannabinoid-1 Receptor Inverse Agonist

Fast food nation! The title compound (pictured) was identified as a potential peripheral CB1‐acting antagonist based on its negative central effects in CB1R agonist‐induced hypothermia and analgesia models, and low brain exposure as indicated by the blood‐to‐plasma ratio. This compound represents a...

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