Absence of Microbiota (Germ-Free Conditions) Accelerates the Atherosclerosis in ApoE-Deficient Mice Fed Standard Low Cholesterol Diet

Aim: The aim of our work was to determine the influence of intestinal bacteria on the development of atherosclerotic lesions using apolipoprotein E (ApoE)-deficient knockout mice. Methods: The experiments were performed on ApoE-/--deficient mouse strain C57BL/6, bred under germ-free (GF) conditions...

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Veröffentlicht in:	Journal of Atherosclerosis and Thrombosis 2010, Vol.17(8), pp.796-804
Hauptverfasser:	Stepankova, Renata, Tonar, Zbynek, Bartova, Jirina, Nedorost, Lukas, Rossman, Pavel, Poledne, Rudolf, Schwarzer, Martin, Tlaskalova-Hogenova, Helena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Apolipoproteins E - physiology Atherogenesis Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - prevention & control Blotting, Western Cholesterol - blood Cholesterol, Dietary - administration & dosage Commensal bacteria Disease Models, Animal Female Germ-Free Life Germ-free mice Intestinal Mucosa - microbiology Male Metagenome Mice Mice, Inbred C57BL Mice, Knockout Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics
Online-Zugang:	Volltext
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