Vitamin D deficiency in morbidly obese patients. A case-control study
Recent studies show a high prevalence of vitamin D deficiency in the general population, especially in the elderly. There are also studies reporting the same observations in the morbidly obese, although few of these studies have compared morbidly obese individuals with non-obese persons. The objecti...
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| Veröffentlicht in: | Endocrinologia y nutricion 2010-06, Vol.57 (6), p.256-261 |
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| creator | Herranz Antolín, Sandra García Martínez, María del Carmen Alvarez De Frutos, Visitación |
| description | Recent studies show a high prevalence of vitamin D deficiency in the general population, especially in the elderly. There are also studies reporting the same observations in the morbidly obese, although few of these studies have compared morbidly obese individuals with non-obese persons. The objectives of this study were to estimate the prevalence of vitamin D deficiency and secondary hyperparathyroidism in both groups and to assess whether there is a relationship between obesity and vitamin D deficiency.
This study was carried out in 138 patients in the Guadalajara University Hospital (Spain) between December 2008 and December 2009. Of these, 50.7% were morbidly obese and 49.3% were not obese. Fasting blood samples were taken from both groups for determination of 25-hydroxyvitamin D, intact parathyroid hormone, calcium, albumin and phosphorus, among other biochemical parameters.
The mean concentration of 25-hydroxyvitamin D was 16.6+/-8.12 ng/ml in the morbidly obese group and 21.9+/-7.34 ng/ml in the non-obese group (p |
| doi_str_mv | 10.1016/j.endonu.2010.04.003 |
| format | Article |
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This study was carried out in 138 patients in the Guadalajara University Hospital (Spain) between December 2008 and December 2009. Of these, 50.7% were morbidly obese and 49.3% were not obese. Fasting blood samples were taken from both groups for determination of 25-hydroxyvitamin D, intact parathyroid hormone, calcium, albumin and phosphorus, among other biochemical parameters.
The mean concentration of 25-hydroxyvitamin D was 16.6+/-8.12 ng/ml in the morbidly obese group and 21.9+/-7.34 ng/ml in the non-obese group (p<0.0001). The prevalence of vitamin D deficiency was 80% in morbidly obese patients and 41% in non-obese patients (p<0.0001). There were no statistically significant differences in concentrations of parathyroid hormone, calcium or phosphorus between the two groups.
A high prevalence of vitamin D deficiency was found in both groups studied, although the concentration of 25-hydroxyvitamin D was significantly lower in the morbidly obese. Morbid obesity is closely linked to vitamin D deficiency. To prevent this deficiency, determination of 25-hydroxyvitamin D should be included in clinical practice guidelines for the treatment of obesity.</description><identifier>EISSN: 1579-2021</identifier><identifier>DOI: 10.1016/j.endonu.2010.04.003</identifier><identifier>PMID: 20494635</identifier><language>spa</language><publisher>Spain</publisher><subject>Adult ; Case-Control Studies ; Female ; Humans ; Hyperparathyroidism, Secondary - epidemiology ; Hyperparathyroidism, Secondary - etiology ; Male ; Middle Aged ; Obesity, Morbid - complications ; Prevalence ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - etiology</subject><ispartof>Endocrinologia y nutricion, 2010-06, Vol.57 (6), p.256-261</ispartof><rights>2010 SEEN. Published by Elsevier Espana. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20494635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herranz Antolín, Sandra</creatorcontrib><creatorcontrib>García Martínez, María del Carmen</creatorcontrib><creatorcontrib>Alvarez De Frutos, Visitación</creatorcontrib><title>Vitamin D deficiency in morbidly obese patients. A case-control study</title><title>Endocrinologia y nutricion</title><addtitle>Endocrinol Nutr</addtitle><description>Recent studies show a high prevalence of vitamin D deficiency in the general population, especially in the elderly. There are also studies reporting the same observations in the morbidly obese, although few of these studies have compared morbidly obese individuals with non-obese persons. The objectives of this study were to estimate the prevalence of vitamin D deficiency and secondary hyperparathyroidism in both groups and to assess whether there is a relationship between obesity and vitamin D deficiency.
This study was carried out in 138 patients in the Guadalajara University Hospital (Spain) between December 2008 and December 2009. Of these, 50.7% were morbidly obese and 49.3% were not obese. Fasting blood samples were taken from both groups for determination of 25-hydroxyvitamin D, intact parathyroid hormone, calcium, albumin and phosphorus, among other biochemical parameters.
The mean concentration of 25-hydroxyvitamin D was 16.6+/-8.12 ng/ml in the morbidly obese group and 21.9+/-7.34 ng/ml in the non-obese group (p<0.0001). The prevalence of vitamin D deficiency was 80% in morbidly obese patients and 41% in non-obese patients (p<0.0001). There were no statistically significant differences in concentrations of parathyroid hormone, calcium or phosphorus between the two groups.
A high prevalence of vitamin D deficiency was found in both groups studied, although the concentration of 25-hydroxyvitamin D was significantly lower in the morbidly obese. Morbid obesity is closely linked to vitamin D deficiency. To prevent this deficiency, determination of 25-hydroxyvitamin D should be included in clinical practice guidelines for the treatment of obesity.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperparathyroidism, Secondary - epidemiology</subject><subject>Hyperparathyroidism, Secondary - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity, Morbid - complications</subject><subject>Prevalence</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - etiology</subject><issn>1579-2021</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T0tLxDAYDIK46-o_EMnNU-uXpGma47KuD1jwsngtafIVsrRNbdJD_70F9TTMg2GGkAcGOQNWPl9yHFwY5pzDKkGRA4grsmVS6YwDZxtyG-MFgEst-A3ZcCh0UQq5Jccvn0zvB_pCHbbeehzsQlfeh6nxrltoaDAiHU1arRRzuqfWRMxsGNIUOhrT7JY7ct2aLuL9H-7I-fV4Prxnp8-3j8P-lI1SysxqEK4qoLVcMdY6zVbK1hkloJWo0OmmErpFKV1hOKBx0qiyqRSigLIRO_L0WztO4XvGmOreR4tdZwYMc6yVFFqLSlVr8vEvOTc9unqcfG-mpf4_Ln4AS3RaBA</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Herranz Antolín, Sandra</creator><creator>García Martínez, María del Carmen</creator><creator>Alvarez De Frutos, Visitación</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201006</creationdate><title>Vitamin D deficiency in morbidly obese patients. A case-control study</title><author>Herranz Antolín, Sandra ; García Martínez, María del Carmen ; Alvarez De Frutos, Visitación</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p555-c903d840fc2711fd913d8163560ec5e7ed9b839fe55d4a20ead5a76b87ee306b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperparathyroidism, Secondary - epidemiology</topic><topic>Hyperparathyroidism, Secondary - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity, Morbid - complications</topic><topic>Prevalence</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - etiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Herranz Antolín, Sandra</creatorcontrib><creatorcontrib>García Martínez, María del Carmen</creatorcontrib><creatorcontrib>Alvarez De Frutos, Visitación</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinologia y nutricion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herranz Antolín, Sandra</au><au>García Martínez, María del Carmen</au><au>Alvarez De Frutos, Visitación</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D deficiency in morbidly obese patients. A case-control study</atitle><jtitle>Endocrinologia y nutricion</jtitle><addtitle>Endocrinol Nutr</addtitle><date>2010-06</date><risdate>2010</risdate><volume>57</volume><issue>6</issue><spage>256</spage><epage>261</epage><pages>256-261</pages><eissn>1579-2021</eissn><abstract>Recent studies show a high prevalence of vitamin D deficiency in the general population, especially in the elderly. There are also studies reporting the same observations in the morbidly obese, although few of these studies have compared morbidly obese individuals with non-obese persons. The objectives of this study were to estimate the prevalence of vitamin D deficiency and secondary hyperparathyroidism in both groups and to assess whether there is a relationship between obesity and vitamin D deficiency.
This study was carried out in 138 patients in the Guadalajara University Hospital (Spain) between December 2008 and December 2009. Of these, 50.7% were morbidly obese and 49.3% were not obese. Fasting blood samples were taken from both groups for determination of 25-hydroxyvitamin D, intact parathyroid hormone, calcium, albumin and phosphorus, among other biochemical parameters.
The mean concentration of 25-hydroxyvitamin D was 16.6+/-8.12 ng/ml in the morbidly obese group and 21.9+/-7.34 ng/ml in the non-obese group (p<0.0001). The prevalence of vitamin D deficiency was 80% in morbidly obese patients and 41% in non-obese patients (p<0.0001). There were no statistically significant differences in concentrations of parathyroid hormone, calcium or phosphorus between the two groups.
A high prevalence of vitamin D deficiency was found in both groups studied, although the concentration of 25-hydroxyvitamin D was significantly lower in the morbidly obese. Morbid obesity is closely linked to vitamin D deficiency. To prevent this deficiency, determination of 25-hydroxyvitamin D should be included in clinical practice guidelines for the treatment of obesity.</abstract><cop>Spain</cop><pmid>20494635</pmid><doi>10.1016/j.endonu.2010.04.003</doi><tpages>6</tpages></addata></record> |
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| ispartof | Endocrinologia y nutricion, 2010-06, Vol.57 (6), p.256-261 |
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| language | spa |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB Electronic Journals Library |
| subjects | Adult Case-Control Studies Female Humans Hyperparathyroidism, Secondary - epidemiology Hyperparathyroidism, Secondary - etiology Male Middle Aged Obesity, Morbid - complications Prevalence Vitamin D Deficiency - epidemiology Vitamin D Deficiency - etiology |
| title | Vitamin D deficiency in morbidly obese patients. A case-control study |
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