Effect of guanethidine on α-adrenoceptor blocking potency of phentolamine in vitro

The effect of guanethidine on the α-adrenoceptor blocking property of phentolamine was studied using the rabbit aortic strip and rat vas deferens. The agonists used were noradrenaline (in presence of DOCA and cocaine which block uptake mechanisms) and xylometazone (which is not taken by uptake mecha...

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Veröffentlicht in:	European journal of pharmacology 1980-10, Vol.67 (4), p.489-492
Hauptverfasser:	Bhavsar, Vinayak H., Joshi, Naresh J., Kelkar, Vasant V., Patel, Manubhai P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Guanethidine Guanethidine - pharmacology Imidazoles - pharmacology In Vitro Techniques Male Muscle Contraction - drug effects Norepinephrine - pharmacology pA 2 value Phentholamine Phentolamine - pharmacology Rabbits Rats Receptors, Adrenergic - drug effects Receptors, Adrenergic, alpha - drug effects Supersensitivity Time Factors Vas Deferens - drug effects
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