Gastric Acid Secretion and Serum Gastrin Levels in Children with Recurrent Abdominal Pain, Gastric and Duodenal Ulcers
Basal and histalog-stimulated gastric acid secretion and serum gastrin levels before and after a standard protein meal were compared in eight children with active duodenal ulcer (DU), four with active gastric ulcer (GU), and in seven children with recurrent abdominal pain (RAP) of undetermined etiol...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1980-09, Vol.2 (3), p.243-246 |
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| creator | Liebman, William M |
| description | Basal and histalog-stimulated gastric acid secretion and serum gastrin levels before and after a standard protein meal were compared in eight children with active duodenal ulcer (DU), four with active gastric ulcer (GU), and in seven children with recurrent abdominal pain (RAP) of undetermined etiology. There was no discernible difference in the pattern of abdominal pain in DU, GU, and RAP. Basal acid output, peak and maximal acid output, whether expressed as mil-liequivalents per hour or as milliequivalents per kilogram per hour, were comparable in children with DU, GU, and RAP. In contrast, serum gastrin levels, 1 and 2 hours after standard protein meal, were significantly higher in the DU children than in the GU or RAP group. These studies have suggested that hypersecretion of gastric acid may not be associated with duodenal ulcer or gastric ulcer disease in children, and that increased gastrin secretion and possible reduced acid responsiveness coexist in children with duodenal ulcers. |
| doi_str_mv | 10.1097/00004836-198009000-00007 |
| format | Article |
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There was no discernible difference in the pattern of abdominal pain in DU, GU, and RAP. Basal acid output, peak and maximal acid output, whether expressed as mil-liequivalents per hour or as milliequivalents per kilogram per hour, were comparable in children with DU, GU, and RAP. In contrast, serum gastrin levels, 1 and 2 hours after standard protein meal, were significantly higher in the DU children than in the GU or RAP group. These studies have suggested that hypersecretion of gastric acid may not be associated with duodenal ulcer or gastric ulcer disease in children, and that increased gastrin secretion and possible reduced acid responsiveness coexist in children with duodenal ulcers.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-198009000-00007</identifier><identifier>PMID: 7451920</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Abdomen ; Acute Disease ; Adolescent ; Child ; Duodenal Ulcer - etiology ; Duodenal Ulcer - physiopathology ; Female ; Gastric Acid - metabolism ; Gastrins - blood ; Humans ; Male ; Pain - etiology ; Pain - physiopathology ; Recurrence ; Stomach Ulcer - etiology ; Stomach Ulcer - physiopathology</subject><ispartof>Journal of clinical gastroenterology, 1980-09, Vol.2 (3), p.243-246</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3557-7dd27e00ab3676c194d009d6eb2c096981d4efe874942631f959c517a4955ff53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7451920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liebman, William M</creatorcontrib><title>Gastric Acid Secretion and Serum Gastrin Levels in Children with Recurrent Abdominal Pain, Gastric and Duodenal Ulcers</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>Basal and histalog-stimulated gastric acid secretion and serum gastrin levels before and after a standard protein meal were compared in eight children with active duodenal ulcer (DU), four with active gastric ulcer (GU), and in seven children with recurrent abdominal pain (RAP) of undetermined etiology. There was no discernible difference in the pattern of abdominal pain in DU, GU, and RAP. Basal acid output, peak and maximal acid output, whether expressed as mil-liequivalents per hour or as milliequivalents per kilogram per hour, were comparable in children with DU, GU, and RAP. In contrast, serum gastrin levels, 1 and 2 hours after standard protein meal, were significantly higher in the DU children than in the GU or RAP group. These studies have suggested that hypersecretion of gastric acid may not be associated with duodenal ulcer or gastric ulcer disease in children, and that increased gastrin secretion and possible reduced acid responsiveness coexist in children with duodenal ulcers.</description><subject>Abdomen</subject><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Child</subject><subject>Duodenal Ulcer - etiology</subject><subject>Duodenal Ulcer - physiopathology</subject><subject>Female</subject><subject>Gastric Acid - metabolism</subject><subject>Gastrins - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Pain - etiology</subject><subject>Pain - physiopathology</subject><subject>Recurrence</subject><subject>Stomach Ulcer - etiology</subject><subject>Stomach Ulcer - physiopathology</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UcFu3CAURFGjdJP2EyJx6qlOwIAxx9U2TSKtlChpzoiFZy0ttrdgZ9W_D653cwsXmDfz5ukNCGFKrihR8prkw2tWFVTVhKiMiqkkT9CCCqaKkjD6CS0IVWVBpCKf0XlKvwmhkjF6hs4kF5kiC_R6a9IQvcVL6x1-Bhth8H2HTTehOLZ4FnR4Da8QEs6v1dYHF6HDez9s8RPYMWY04OXG9a3vTMCPxnff8dF68vox9g4m6iVYiOkLOm1MSPD1cF-gl583v1Z3xfrh9n61XBeWCSEL6VwpgRCzYZWsLFXc5W1dBZvSElWpmjoODdSSK15WjDZKKCuoNFwJ0TSCXaBvs-8u9n9HSINufbIQgumgH5OWOSyqKp6F9Sy0sU8pQqN30bcm_tOU6ClyfYxcv0f-vyRz6-Vhxrhpwb03HjLOPJ_5fR-GvPufMO4h6i2YMGz1Rz_J3gBik4sY</recordid><startdate>198009</startdate><enddate>198009</enddate><creator>Liebman, William M</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>198009</creationdate><title>Gastric Acid Secretion and Serum Gastrin Levels in Children with Recurrent Abdominal Pain, Gastric and Duodenal Ulcers</title><author>Liebman, William M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3557-7dd27e00ab3676c194d009d6eb2c096981d4efe874942631f959c517a4955ff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Abdomen</topic><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Child</topic><topic>Duodenal Ulcer - etiology</topic><topic>Duodenal Ulcer - physiopathology</topic><topic>Female</topic><topic>Gastric Acid - metabolism</topic><topic>Gastrins - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Pain - etiology</topic><topic>Pain - physiopathology</topic><topic>Recurrence</topic><topic>Stomach Ulcer - etiology</topic><topic>Stomach Ulcer - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liebman, William M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liebman, William M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric Acid Secretion and Serum Gastrin Levels in Children with Recurrent Abdominal Pain, Gastric and Duodenal Ulcers</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1980-09</date><risdate>1980</risdate><volume>2</volume><issue>3</issue><spage>243</spage><epage>246</epage><pages>243-246</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><abstract>Basal and histalog-stimulated gastric acid secretion and serum gastrin levels before and after a standard protein meal were compared in eight children with active duodenal ulcer (DU), four with active gastric ulcer (GU), and in seven children with recurrent abdominal pain (RAP) of undetermined etiology. There was no discernible difference in the pattern of abdominal pain in DU, GU, and RAP. Basal acid output, peak and maximal acid output, whether expressed as mil-liequivalents per hour or as milliequivalents per kilogram per hour, were comparable in children with DU, GU, and RAP. In contrast, serum gastrin levels, 1 and 2 hours after standard protein meal, were significantly higher in the DU children than in the GU or RAP group. These studies have suggested that hypersecretion of gastric acid may not be associated with duodenal ulcer or gastric ulcer disease in children, and that increased gastrin secretion and possible reduced acid responsiveness coexist in children with duodenal ulcers.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>7451920</pmid><doi>10.1097/00004836-198009000-00007</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 1980-09, Vol.2 (3), p.243-246 |
| issn | 0192-0790 1539-2031 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Abdomen Acute Disease Adolescent Child Duodenal Ulcer - etiology Duodenal Ulcer - physiopathology Female Gastric Acid - metabolism Gastrins - blood Humans Male Pain - etiology Pain - physiopathology Recurrence Stomach Ulcer - etiology Stomach Ulcer - physiopathology |
| title | Gastric Acid Secretion and Serum Gastrin Levels in Children with Recurrent Abdominal Pain, Gastric and Duodenal Ulcers |
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