Enterohepatic recycling of phenolphthalein, morphine, lysergic acid diethylamide (LSD) and diphenylacetic acid in the rat Hydrolysis of glucuronic acid conjugates in the gut lumen

1. Biliary elimination in female Wistar albino rats 3h after i.p. injection of [3H]phenolphthalein, [3H]morphine, 14C-LSD and [14C]diphenylacetic acid was 90%, 45%, 75% and 57% respectively, predominantly as glucuronides. 2. Infusion of 3 h bile from the previous experiments into the duodena of bile...

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Veröffentlicht in:	Xenobiotica 1980-01, Vol.10 (9), p.689-703
Hauptverfasser:	Parker, R. J., Hirom, P. C., Millburn, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Bile Ducts - physiology Diphenylacetic Acids - metabolism Enterohepatic Circulation Female Glucuronates - metabolism Hydrolysis Intestines - metabolism Lysergic Acid Diethylamide - metabolism Morphine - metabolism Phenolphthaleins - metabolism Rats
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