Orally active vasodilators in the management of chronic treatment-resistant cardiac failure (author's transl)
The acute haemodynamic effects of 40 mg isosorbide dinitrate (10 subjects), 4 mg prazosin (20 subjects) and 50 mg dihydralazine (8 subjects) were compared in 24 patients with the clinical picture of chronic therapy-resistant cardiac failure (NY Heart Association stages III-IV). There was a fall in l...
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| Veröffentlicht in: | Deutsche medizinische Wochenschrift 1980-10, Vol.105 (40), p.1379-1383 |
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| container_issue | 40 |
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| container_title | Deutsche medizinische Wochenschrift |
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| creator | Wirtzfeld, A Klein, G Himmler, F C Schmidt, G Kutschera, I Sauer, E |
| description | The acute haemodynamic effects of 40 mg isosorbide dinitrate (10 subjects), 4 mg prazosin (20 subjects) and 50 mg dihydralazine (8 subjects) were compared in 24 patients with the clinical picture of chronic therapy-resistant cardiac failure (NY Heart Association stages III-IV). There was a fall in left-ventricular filling pressure of about 15% and right-atrial mean pressure of 21 and 24%, respectively, with isosorbide dinitrate and prazosin, while there was no change with dihydralazine. Cardiac output rose by 23% with dihydralazine and 20% with prazosin, but remained unchanged with isosorbide dinitrate. These data indicate that a reduction in pulmonary and systemic-venous congestion due to chronic decompensated cardiac failure can be achieved with isosorbide dinitrate and prazosin, while cardiac output can be improved only with prazosin and dihydralazine. |
| doi_str_mv | 10.1055/s-2008-1070875 |
| format | Article |
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There was a fall in left-ventricular filling pressure of about 15% and right-atrial mean pressure of 21 and 24%, respectively, with isosorbide dinitrate and prazosin, while there was no change with dihydralazine. Cardiac output rose by 23% with dihydralazine and 20% with prazosin, but remained unchanged with isosorbide dinitrate. 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| fulltext | fulltext |
| identifier | ISSN: 0012-0472 |
| ispartof | Deutsche medizinische Wochenschrift, 1980-10, Vol.105 (40), p.1379-1383 |
| issn | 0012-0472 |
| language | ger |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Aged Dihydralazine - therapeutic use Heart Failure - drug therapy Hemodynamics - drug effects Humans Hydralazine - analogs & derivatives Isosorbide Dinitrate - therapeutic use Middle Aged Prazosin - therapeutic use Quinazolines - therapeutic use |
| title | Orally active vasodilators in the management of chronic treatment-resistant cardiac failure (author's transl) |
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