Characterization of the interaction between human lactoferrin and lomefloxacin at physiological condition: Multi-spectroscopic and modeling description

The interaction between lomefloxacin (LMF) and human lactoferrin (Hlf) was studied by using fluorescence, circular dichroism (CD) spectroscopic and molecular modeling measurements. By the fluorescence quenching results, it was found that the binding constant K A=8.69×10 5 L mol −1, and number of bin...

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Veröffentlicht in:	Journal of luminescence 2010-07, Vol.130 (7), p.1160-1168
Hauptverfasser:	Chamani, J., Tafrishi, N., Momen-Heravi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Binding constant Binding sites Biological and medical sciences Energy transfer Fluorescence Fluorescence quenching spectroscopy Fundamental and applied biological sciences. Psychology Human lactoferrin Interactions. Associations Intermolecular phenomena Lomefloxacin Mathematical models Molecular biophysics Perturbation methods Quenching Secondary structure Thermodynamics
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