Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice
Arecoline is a plant alkaloid of betel nut Areca catechu. Arecoline has immunosuppressive, hepatotoxic, mutagenic and teratogenic effects, and disturbs some endocrine organs in rats. The objective is to investigate the untoward effects of arecoline on the thyroid gland in mice. Intraperitoneal injec...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2010-05, Vol.319 (1), p.1-7 |
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| creator | Dasgupta, Romi Chatterji, Urmi Nag, T.C. Chaudhuri-Sengupta, Santasri Nag, Debabrata Maiti, B.R. |
| description | Arecoline is a plant alkaloid of betel nut
Areca catechu. Arecoline has immunosuppressive, hepatotoxic, mutagenic and teratogenic effects, and disturbs some endocrine organs in rats. The objective is to investigate the untoward effects of arecoline on the thyroid gland in mice. Intraperitoneal injection of arecoline (10
mg/kg body weight only once) increased the serum T
3 and T
4 levels and decreased the serum TSH 20, 40 or 60
min after the treatment, with maximum effect at 40
min. Chronic arecoline treatment (10
mg/kg body weight daily for 15 days) caused light microscopic and ultrastructural degenerations of thyro-follicular cells with depletion of T
3 and T
4 levels followed by the elevation of the TSH level. Atropine (arecoline antagonist) injection prevented the changes (hyperactivity) induced by acute (40
min) arecline treatment. Arecoline initially stimulates thyroid activity, and eventually inhibits the activity; atropine prevents thyroid dysfunction induced by arecoline. Arecoline action is mediated probably via muscarinic cholinergic receptor—hypothalamic–pituitary–thyroid axis in mice. |
| doi_str_mv | 10.1016/j.mce.2010.01.005 |
| format | Article |
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Areca catechu. Arecoline has immunosuppressive, hepatotoxic, mutagenic and teratogenic effects, and disturbs some endocrine organs in rats. The objective is to investigate the untoward effects of arecoline on the thyroid gland in mice. Intraperitoneal injection of arecoline (10
mg/kg body weight only once) increased the serum T
3 and T
4 levels and decreased the serum TSH 20, 40 or 60
min after the treatment, with maximum effect at 40
min. Chronic arecoline treatment (10
mg/kg body weight daily for 15 days) caused light microscopic and ultrastructural degenerations of thyro-follicular cells with depletion of T
3 and T
4 levels followed by the elevation of the TSH level. Atropine (arecoline antagonist) injection prevented the changes (hyperactivity) induced by acute (40
min) arecline treatment. Arecoline initially stimulates thyroid activity, and eventually inhibits the activity; atropine prevents thyroid dysfunction induced by arecoline. Arecoline action is mediated probably via muscarinic cholinergic receptor—hypothalamic–pituitary–thyroid axis in mice.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/j.mce.2010.01.005</identifier><identifier>PMID: 20085799</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Analysis of Variance ; Animals ; Arecoline ; Arecoline - pharmacology ; Atropine ; Atropine - pharmacology ; Body weight ; Catechu ; Cell Size - drug effects ; Cholinergic Agonists - pharmacology ; Cholinergic Antagonists - pharmacology ; Elevation ; Epithelial Cells - cytology ; Epithelial Cells - drug effects ; Male ; Mice ; Microscopy, Electron, Transmission ; Modulation ; Serums ; Thyroid ; Thyroid gland ; Thyroid Gland - drug effects ; Thyroid Gland - metabolism ; Thyroid Gland - ultrastructure ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>Molecular and cellular endocrinology, 2010-05, Vol.319 (1), p.1-7</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>Copyright 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-3ff113c3926a1454d114bceb67f72dece6d5da67f94608204b954e920e4d9c6b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mce.2010.01.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20085799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dasgupta, Romi</creatorcontrib><creatorcontrib>Chatterji, Urmi</creatorcontrib><creatorcontrib>Nag, T.C.</creatorcontrib><creatorcontrib>Chaudhuri-Sengupta, Santasri</creatorcontrib><creatorcontrib>Nag, Debabrata</creatorcontrib><creatorcontrib>Maiti, B.R.</creatorcontrib><title>Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>Arecoline is a plant alkaloid of betel nut
Areca catechu. Arecoline has immunosuppressive, hepatotoxic, mutagenic and teratogenic effects, and disturbs some endocrine organs in rats. The objective is to investigate the untoward effects of arecoline on the thyroid gland in mice. Intraperitoneal injection of arecoline (10
mg/kg body weight only once) increased the serum T
3 and T
4 levels and decreased the serum TSH 20, 40 or 60
min after the treatment, with maximum effect at 40
min. Chronic arecoline treatment (10
mg/kg body weight daily for 15 days) caused light microscopic and ultrastructural degenerations of thyro-follicular cells with depletion of T
3 and T
4 levels followed by the elevation of the TSH level. Atropine (arecoline antagonist) injection prevented the changes (hyperactivity) induced by acute (40
min) arecline treatment. Arecoline initially stimulates thyroid activity, and eventually inhibits the activity; atropine prevents thyroid dysfunction induced by arecoline. Arecoline action is mediated probably via muscarinic cholinergic receptor—hypothalamic–pituitary–thyroid axis in mice.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Arecoline</subject><subject>Arecoline - pharmacology</subject><subject>Atropine</subject><subject>Atropine - pharmacology</subject><subject>Body weight</subject><subject>Catechu</subject><subject>Cell Size - drug effects</subject><subject>Cholinergic Agonists - pharmacology</subject><subject>Cholinergic Antagonists - pharmacology</subject><subject>Elevation</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial Cells - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Microscopy, Electron, Transmission</subject><subject>Modulation</subject><subject>Serums</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - ultrastructure</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFO3DAQhq2qCBbKA_RS-cYpy9hO4kScEKItEhIXOFuOPQGvHJvaThFvX6-W9tjDyPqlb36NP0K-MtgyYP3lbrsY3HKoGdgWoPtENmyQvBmgk5_JBgSIRnKQJ-Q05x0AyI4Px-SEAwydHMcN2T35knQuaTVlTdpTHSx9iWmJoYYl2tXr4mLINM60vGCd9xSdpc9-T87R-_jmwjPVCU30LlQioS4LhkJdoNpPLkS6OINfyNGsfcbzj_eMPH2_fbz52dw__Li7ub5vjBja0oh5ZkwYMfJes7ZrLWPtZHDq5Sy5RYO97ayuaWx7GDi009i1OHLA1o6mn8QZuTj0vqb4a8Vc1OKyQV8PxrhmJTshxSC4qCQ7kCbFnBPO6jW5Rad3xUDtDaudqobV3rACpqrhuvPto32dFrT_Nv4qrcDVAcD6x98Ok8rGYTBoXVVUlI3uP_V_AM6OjdE</recordid><startdate>20100505</startdate><enddate>20100505</enddate><creator>Dasgupta, Romi</creator><creator>Chatterji, Urmi</creator><creator>Nag, T.C.</creator><creator>Chaudhuri-Sengupta, Santasri</creator><creator>Nag, Debabrata</creator><creator>Maiti, B.R.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20100505</creationdate><title>Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice</title><author>Dasgupta, Romi ; Chatterji, Urmi ; Nag, T.C. ; Chaudhuri-Sengupta, Santasri ; Nag, Debabrata ; Maiti, B.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-3ff113c3926a1454d114bceb67f72dece6d5da67f94608204b954e920e4d9c6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Arecoline</topic><topic>Arecoline - pharmacology</topic><topic>Atropine</topic><topic>Atropine - pharmacology</topic><topic>Body weight</topic><topic>Catechu</topic><topic>Cell Size - drug effects</topic><topic>Cholinergic Agonists - pharmacology</topic><topic>Cholinergic Antagonists - pharmacology</topic><topic>Elevation</topic><topic>Epithelial Cells - cytology</topic><topic>Epithelial Cells - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Microscopy, Electron, Transmission</topic><topic>Modulation</topic><topic>Serums</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - ultrastructure</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dasgupta, Romi</creatorcontrib><creatorcontrib>Chatterji, Urmi</creatorcontrib><creatorcontrib>Nag, T.C.</creatorcontrib><creatorcontrib>Chaudhuri-Sengupta, Santasri</creatorcontrib><creatorcontrib>Nag, Debabrata</creatorcontrib><creatorcontrib>Maiti, B.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dasgupta, Romi</au><au>Chatterji, Urmi</au><au>Nag, T.C.</au><au>Chaudhuri-Sengupta, Santasri</au><au>Nag, Debabrata</au><au>Maiti, B.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>2010-05-05</date><risdate>2010</risdate><volume>319</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><abstract>Arecoline is a plant alkaloid of betel nut
Areca catechu. Arecoline has immunosuppressive, hepatotoxic, mutagenic and teratogenic effects, and disturbs some endocrine organs in rats. The objective is to investigate the untoward effects of arecoline on the thyroid gland in mice. Intraperitoneal injection of arecoline (10
mg/kg body weight only once) increased the serum T
3 and T
4 levels and decreased the serum TSH 20, 40 or 60
min after the treatment, with maximum effect at 40
min. Chronic arecoline treatment (10
mg/kg body weight daily for 15 days) caused light microscopic and ultrastructural degenerations of thyro-follicular cells with depletion of T
3 and T
4 levels followed by the elevation of the TSH level. Atropine (arecoline antagonist) injection prevented the changes (hyperactivity) induced by acute (40
min) arecline treatment. Arecoline initially stimulates thyroid activity, and eventually inhibits the activity; atropine prevents thyroid dysfunction induced by arecoline. Arecoline action is mediated probably via muscarinic cholinergic receptor—hypothalamic–pituitary–thyroid axis in mice.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>20085799</pmid><doi>10.1016/j.mce.2010.01.005</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis of Variance Animals Arecoline Arecoline - pharmacology Atropine Atropine - pharmacology Body weight Catechu Cell Size - drug effects Cholinergic Agonists - pharmacology Cholinergic Antagonists - pharmacology Elevation Epithelial Cells - cytology Epithelial Cells - drug effects Male Mice Microscopy, Electron, Transmission Modulation Serums Thyroid Thyroid gland Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Gland - ultrastructure Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood |
| title | Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice |
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