Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women
Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common iron disorders throughout the world. ID and IDA, particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth retardation, low birth weight, and inferior neonata...
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| Veröffentlicht in: | Biometals 2010-06, Vol.23 (3), p.411-417 |
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| creator | Paesano, Rosalba Berlutti, Francesca Pietropaoli, Miriam Pantanella, Fabrizio Pacifici, Enrica Goolsbee, William Valenti, Piera |
| description | Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common iron disorders throughout the world. ID and IDA, particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth retardation, low birth weight, and inferior neonatal health. Oral administration of ferrous sulfate to cure ID and IDA in pregnancy often fails to increase hematological parameters, causes adverse effects and increases inflammation. Recently, we have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women suffering from ID and IDA. Oral administration of bLf significantly increases the number of red blood cells, hemoglobin, total serum iron and serum ferritin already after 30 days of the treatment. The increasing of hematological values by bLf is related to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases IL-6 and fails to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA in pregnant women. |
| doi_str_mv | 10.1007/s10534-010-9335-z |
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ID and IDA, particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth retardation, low birth weight, and inferior neonatal health. Oral administration of ferrous sulfate to cure ID and IDA in pregnancy often fails to increase hematological parameters, causes adverse effects and increases inflammation. Recently, we have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women suffering from ID and IDA. Oral administration of bLf significantly increases the number of red blood cells, hemoglobin, total serum iron and serum ferritin already after 30 days of the treatment. The increasing of hematological values by bLf is related to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases IL-6 and fails to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA in pregnant women.</description><identifier>ISSN: 0966-0844</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-010-9335-z</identifier><identifier>PMID: 20407805</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Anemia ; Anemia, Iron-Deficiency - drug therapy ; Anemias ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cures ; Female ; Ferritin ; Ferrous Compounds - administration & dosage ; Ferrous Compounds - adverse effects ; Ferrous Compounds - therapeutic use ; Hematology ; Hemoglobin ; Humans ; Iron ; Iron - deficiency ; Lactoferrin - administration & dosage ; Lactoferrin - immunology ; Lactoferrin - therapeutic use ; Life Sciences ; Medicine/Public Health ; Microbiology ; Nutrient deficiency ; Peptides ; Pharmacology/Toxicology ; Plant Physiology ; Pregnancy ; Pregnancy Complications, Hematologic - drug therapy ; Prenatal care ; Serums ; Sulfates</subject><ispartof>Biometals, 2010-06, Vol.23 (3), p.411-417</ispartof><rights>Springer Science+Business Media, LLC. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-547b0e7977ba3070de60d36c17027d8c0217374f86d78f9e7dcf0447b6d71f063</citedby><cites>FETCH-LOGICAL-c468t-547b0e7977ba3070de60d36c17027d8c0217374f86d78f9e7dcf0447b6d71f063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10534-010-9335-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10534-010-9335-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20407805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paesano, Rosalba</creatorcontrib><creatorcontrib>Berlutti, Francesca</creatorcontrib><creatorcontrib>Pietropaoli, Miriam</creatorcontrib><creatorcontrib>Pantanella, Fabrizio</creatorcontrib><creatorcontrib>Pacifici, Enrica</creatorcontrib><creatorcontrib>Goolsbee, William</creatorcontrib><creatorcontrib>Valenti, Piera</creatorcontrib><title>Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women</title><title>Biometals</title><addtitle>Biometals</addtitle><addtitle>Biometals</addtitle><description>Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common iron disorders throughout the world. ID and IDA, particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth retardation, low birth weight, and inferior neonatal health. Oral administration of ferrous sulfate to cure ID and IDA in pregnancy often fails to increase hematological parameters, causes adverse effects and increases inflammation. Recently, we have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women suffering from ID and IDA. Oral administration of bLf significantly increases the number of red blood cells, hemoglobin, total serum iron and serum ferritin already after 30 days of the treatment. The increasing of hematological values by bLf is related to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases IL-6 and fails to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA in pregnant women.</description><subject>Anemia</subject><subject>Anemia, Iron-Deficiency - drug therapy</subject><subject>Anemias</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cures</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferrous Compounds - administration & dosage</subject><subject>Ferrous Compounds - adverse effects</subject><subject>Ferrous Compounds - therapeutic use</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron - 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ID and IDA, particularly caused by increased iron requirements during pregnancy, represent a high risk for preterm delivery, fetal growth retardation, low birth weight, and inferior neonatal health. Oral administration of ferrous sulfate to cure ID and IDA in pregnancy often fails to increase hematological parameters, causes adverse effects and increases inflammation. Recently, we have demonstrated safety and efficacy of oral administration of 30% iron saturated bovine lactoferrin (bLf) in pregnant women suffering from ID and IDA. Oral administration of bLf significantly increases the number of red blood cells, hemoglobin, total serum iron and serum ferritin already after 30 days of the treatment. The increasing of hematological values by bLf is related to the decrease of serum IL-6 and the increase of serum hepcidin, detected as prohepcidin, whereas ferrous sulfate increases IL-6 and fails to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA in pregnant women.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>20407805</pmid><doi>10.1007/s10534-010-9335-z</doi><tpages>7</tpages></addata></record> |
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| subjects | Anemia Anemia, Iron-Deficiency - drug therapy Anemias Animals Biochemistry Biomedical and Life Sciences Cell Biology Cures Female Ferritin Ferrous Compounds - administration & dosage Ferrous Compounds - adverse effects Ferrous Compounds - therapeutic use Hematology Hemoglobin Humans Iron Iron - deficiency Lactoferrin - administration & dosage Lactoferrin - immunology Lactoferrin - therapeutic use Life Sciences Medicine/Public Health Microbiology Nutrient deficiency Peptides Pharmacology/Toxicology Plant Physiology Pregnancy Pregnancy Complications, Hematologic - drug therapy Prenatal care Serums Sulfates |
| title | Lactoferrin efficacy versus ferrous sulfate in curing iron deficiency and iron deficiency anemia in pregnant women |
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