Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut-induced carcinogenesis

The aqueous extract of betel nut (AEBN) induces the formation of preneoplastic nodules in the liver of Swiss Albino mice and leads to increased predisposition to cancer when administered transgenerationally. The aim of this investigation was to elucidate the alterations in ultrastructure of subcellu...

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Veröffentlicht in:	Microscopy research and technique 2010-05, Vol.73 (5), p.530-539
Hauptverfasser:	Choudhury, Yashmin, Sharan, Rajeshwar N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alterations Animals Areca - chemistry betel nut Cancer Carcinogens Cell Nucleus - ultrastructure Dispersions Endoplasmic Reticulum - ultrastructure Exposure Female Heterochromatin - ultrastructure Liver Liver - drug effects Liver - ultrastructure Male Mice Microscopy, Electron, Transmission Mitochondria - ultrastructure mitochondrial index Nodules Nuclear Envelope - ultrastructure Plant Extracts - administration & dosage Plant Extracts - toxicity predisposition to cancer transgenerational exposure
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