Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway

Epac (Exchange protein directly activated by cAMP) is a sensor for cAMP and represents a novel mechanism for governing cAMP signalling. Epac is a guanine nucleotide exchange factor (GEF) for the Ras family of small GTPases, Rap. Previous studies demonstrated that, in response to a prolonged β-adrene...

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Veröffentlicht in:	Cellular signalling 2010-10, Vol.22 (10), p.1459-1468
Hauptverfasser:	Métrich, Mélanie, Laurent, Anne-Coline, Breckler, Magali, Duquesnes, Nicolas, Hmitou, Isabelle, Courillau, Delphine, Blondeau, Jean-Paul, Crozatier, Bertrand, Lezoualc'h, Frank, Morel, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Active Transport, Cell Nucleus Animals Calcium - metabolism CaMKII Cardiac hypertrophy Cardiomegaly - metabolism Catalytic Domain Cell Nucleus - metabolism Cells, Cultured Cyclic nucleotides Exports Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - metabolism HDAC Histone Deacetylases - metabolism Histones Humans Inositol 1,4,5-Trisphosphate Receptors - metabolism International trade MEF2 Transcription Factors Myocytes, Cardiac - enzymology Myocytes, Cardiac - metabolism Myogenic Regulatory Factors - metabolism NFATC Transcription Factors - metabolism Pathways Product life cycle Proteins Proto-Oncogene Proteins p21(ras) - metabolism Rats Signal Transduction Signalling Small G protein Type C Phospholipases - metabolism
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