Effect of adiponectin on ATDC5 proliferation, differentiation and signaling pathways

Adiponectin, an adipose-secreted adipocytokine, exhibits various metabolic functions but has no known effect on bone development through the growth plate and specifically, in chondrocytes. Using the mouse ATDC5 cell line, a widely used in vitro model of chondrogenesis, we demonstrated the expression...

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Veröffentlicht in:	Molecular and cellular endocrinology 2010-07, Vol.323 (2), p.282-291
Hauptverfasser:	Challa, T. Delessa, Rais, Y., Ornan, E. Monsonego
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytokine Adiponectin Adiponectin - metabolism Adiponectin - pharmacology Aggrecans - genetics Aggrecans - metabolism Animals ATDC5 Biomarkers - metabolism Bone development Cell Differentiation - drug effects Cell Line - drug effects Cell Line - physiology Cell Proliferation - drug effects Chondrocyte Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - physiology Chondrogenesis - drug effects Collagen Type II - genetics Collagen Type II - metabolism Collagen Type X - genetics Collagen Type X - metabolism Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mice Receptors, Adiponectin - genetics Receptors, Adiponectin - metabolism Signal Transduction - drug effects
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