Determination of adrenolytic drugs by SPME-LC-MS
Five adrenolytic drugs have been analyzed by liquid chromatography-mass spectrometry (LC-MS). Samples were prepared by solid-phase microextraction (SPME) using polypyrrole fibers coated on stainless steel support as an adsorbent for the drugs. Adsorption efficiencies were 95% and were close for all...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2010-05, Vol.397 (1), p.173-179 |
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| creator | Buszewski, Boguslaw Olszowy, Pawel Ligor, Tomasz Szultka, Malgorzata Nowaczyk, Jacek Jaworski, Maciej Jackowski, Marek |
| description | Five adrenolytic drugs have been analyzed by liquid chromatography-mass spectrometry (LC-MS). Samples were prepared by solid-phase microextraction (SPME) using polypyrrole fibers coated on stainless steel support as an adsorbent for the drugs. Adsorption efficiencies were 95% and were close for all the drugs investigated. Relative standard deviations (RSD), calculated for samples prepared in standard solutions, were in the range 2.5-13%, however RSD values for the drugs in human plasma were 2.5-4.5%. Using LC-MS the limit of detection (LOD) and the limit of quantification (LOQ) were in the ranges 0.11-0.18 and 0.39-0.54 ng mL⁻¹, respectively, for the five drugs. |
| doi_str_mv | 10.1007/s00216-010-3483-4 |
| format | Article |
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Samples were prepared by solid-phase microextraction (SPME) using polypyrrole fibers coated on stainless steel support as an adsorbent for the drugs. Adsorption efficiencies were 95% and were close for all the drugs investigated. Relative standard deviations (RSD), calculated for samples prepared in standard solutions, were in the range 2.5-13%, however RSD values for the drugs in human plasma were 2.5-4.5%. 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Samples were prepared by solid-phase microextraction (SPME) using polypyrrole fibers coated on stainless steel support as an adsorbent for the drugs. Adsorption efficiencies were 95% and were close for all the drugs investigated. Relative standard deviations (RSD), calculated for samples prepared in standard solutions, were in the range 2.5-13%, however RSD values for the drugs in human plasma were 2.5-4.5%. 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| subjects | Adrenergic Antagonists - blood Adsorption Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - methods Drugs Exact sciences and technology Food Science High performance liquid chromatography Humans Laboratory Medicine Limit of Detection Liquid chromatography Mass spectrometry Mathematical analysis Monitoring/Environmental Analysis Original Paper Other chromatographic methods Solid Phase Microextraction - methods Spectrometric and optical methods Spectrometry, Mass, Electrospray Ionization - methods Steel, Stainless |
| title | Determination of adrenolytic drugs by SPME-LC-MS |
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