Effects of Prolonged Starvation on Plasma Free Fatty Acid Levels and Fatty Acid Composition of Myocardial Total Lipids in the Rat
Experiments were carried out on male rats fed a libitum or starved for a period of 7 days. Plasma levels of free fatty acids (FFA) and the quantity and composition of fatty acids in total lipids of heart ventricular tissue in vivo were analyzed by gas liquid chromatography (GLC). In addition, FFA ex...
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| Veröffentlicht in: | The Journal of nutrition 1980-12, Vol.110 (12), p.2490-2496 |
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| container_title | The Journal of nutrition |
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| creator | Yaffe, Steven Gold, Armand Sampugna, Joseph |
| description | Experiments were carried out on male rats fed a libitum or starved for a period of 7 days. Plasma levels of free fatty acids (FFA) and the quantity and composition of fatty acids in total lipids of heart ventricular tissue in vivo were analyzed by gas liquid chromatography (GLC). In addition, FFA extraction ratios and uptake rates were determined in isolated perfused hearts using the classical Langendorff technique. After 7 days of starvation, distribution and concentrations obtained for total lipid fatty acids from heart ventricles of starved animals were substantially different from those of controls. In particular, 20:5 and 22:6 carbon polyunsaturated fatty acids were significantly elevated. Also, total plasma FFA level was elevated and FFA extraction ratios were increased as a result of prolonged starvation. Accumulation of 20- and 22-carbon polyunsaturated fatty acids observed in ventricles of starved rats may have resulted from increased availability and extraction of FFA. |
| doi_str_mv | 10.1093/jn/110.12.2490 |
| format | Article |
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Plasma levels of free fatty acids (FFA) and the quantity and composition of fatty acids in total lipids of heart ventricular tissue in vivo were analyzed by gas liquid chromatography (GLC). In addition, FFA extraction ratios and uptake rates were determined in isolated perfused hearts using the classical Langendorff technique. After 7 days of starvation, distribution and concentrations obtained for total lipid fatty acids from heart ventricles of starved animals were substantially different from those of controls. In particular, 20:5 and 22:6 carbon polyunsaturated fatty acids were significantly elevated. Also, total plasma FFA level was elevated and FFA extraction ratios were increased as a result of prolonged starvation. Accumulation of 20- and 22-carbon polyunsaturated fatty acids observed in ventricles of starved rats may have resulted from increased availability and extraction of FFA.</description><identifier>ISSN: 0022-3166</identifier><identifier>DOI: 10.1093/jn/110.12.2490</identifier><identifier>PMID: 7441376</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Fatty Acids - metabolism ; Fatty Acids, Nonesterified - blood ; Fatty Acids, Nonesterified - metabolism ; Fatty Acids, Unsaturated - metabolism ; heart ventricle ; Heart Ventricles ; Humans ; Lipid Metabolism ; Myocardium - metabolism ; plasma fatty acids ; Rats ; starvation ; Starvation - metabolism</subject><ispartof>The Journal of nutrition, 1980-12, Vol.110 (12), p.2490-2496</ispartof><rights>1980 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-4010b186f7429a6a680794a34751b9d89e96d1d691c613e9132b32f130d422623</citedby><cites>FETCH-LOGICAL-c379t-4010b186f7429a6a680794a34751b9d89e96d1d691c613e9132b32f130d422623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7441376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yaffe, Steven</creatorcontrib><creatorcontrib>Gold, Armand</creatorcontrib><creatorcontrib>Sampugna, Joseph</creatorcontrib><title>Effects of Prolonged Starvation on Plasma Free Fatty Acid Levels and Fatty Acid Composition of Myocardial Total Lipids in the Rat</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Experiments were carried out on male rats fed a libitum or starved for a period of 7 days. Plasma levels of free fatty acids (FFA) and the quantity and composition of fatty acids in total lipids of heart ventricular tissue in vivo were analyzed by gas liquid chromatography (GLC). In addition, FFA extraction ratios and uptake rates were determined in isolated perfused hearts using the classical Langendorff technique. After 7 days of starvation, distribution and concentrations obtained for total lipid fatty acids from heart ventricles of starved animals were substantially different from those of controls. In particular, 20:5 and 22:6 carbon polyunsaturated fatty acids were significantly elevated. Also, total plasma FFA level was elevated and FFA extraction ratios were increased as a result of prolonged starvation. Accumulation of 20- and 22-carbon polyunsaturated fatty acids observed in ventricles of starved rats may have resulted from increased availability and extraction of FFA.</description><subject>Animals</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>heart ventricle</subject><subject>Heart Ventricles</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Myocardium - metabolism</subject><subject>plasma fatty acids</subject><subject>Rats</subject><subject>starvation</subject><subject>Starvation - metabolism</subject><issn>0022-3166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LAzEQxXNQ_KhevQk5eWubr2Y3RylWhYqi9RzSZFZTdjc1SQs9-p-7S4t4EYaZYea9d_ghdEXJiBLFx6t2TPudjZhQ5AidEcLYkFMpT9F5SitCCBWqPEEnhRCUF_IMfd9VFdiccKjwSwx1aD_A4bds4tZkH1rc1UttUmPwLALgmcl5h2-td3gOW6gTNq37e52GZh2S33sr_LQL1kTnTY0XIXd97tfeJexbnD8Bv5p8gY4rUye4PMwBep_dLaYPw_nz_eP0dj60vFB5KAglS1rKqhBMGWlkSQolDBfFhC6VKxUo6aiTilpJOSjK2ZKzinLiBGOS8QG62eeuY_jaQMq68clCXZsWwibpYsIlEUp0wtFeaGNIKUKl19E3Ju40JbrnrFetpv3OdM-5M1wfkjfLBtyv_AC5-5f7f4cLth6iTtZDa8H52LHXLvj_on8AOm2MQQ</recordid><startdate>198012</startdate><enddate>198012</enddate><creator>Yaffe, Steven</creator><creator>Gold, Armand</creator><creator>Sampugna, Joseph</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198012</creationdate><title>Effects of Prolonged Starvation on Plasma Free Fatty Acid Levels and Fatty Acid Composition of Myocardial Total Lipids in the Rat</title><author>Yaffe, Steven ; Gold, Armand ; Sampugna, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-4010b186f7429a6a680794a34751b9d89e96d1d691c613e9132b32f130d422623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Fatty Acids - metabolism</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>heart ventricle</topic><topic>Heart Ventricles</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Myocardium - metabolism</topic><topic>plasma fatty acids</topic><topic>Rats</topic><topic>starvation</topic><topic>Starvation - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaffe, Steven</creatorcontrib><creatorcontrib>Gold, Armand</creatorcontrib><creatorcontrib>Sampugna, Joseph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaffe, Steven</au><au>Gold, Armand</au><au>Sampugna, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Prolonged Starvation on Plasma Free Fatty Acid Levels and Fatty Acid Composition of Myocardial Total Lipids in the Rat</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1980-12</date><risdate>1980</risdate><volume>110</volume><issue>12</issue><spage>2490</spage><epage>2496</epage><pages>2490-2496</pages><issn>0022-3166</issn><abstract>Experiments were carried out on male rats fed a libitum or starved for a period of 7 days. Plasma levels of free fatty acids (FFA) and the quantity and composition of fatty acids in total lipids of heart ventricular tissue in vivo were analyzed by gas liquid chromatography (GLC). In addition, FFA extraction ratios and uptake rates were determined in isolated perfused hearts using the classical Langendorff technique. After 7 days of starvation, distribution and concentrations obtained for total lipid fatty acids from heart ventricles of starved animals were substantially different from those of controls. In particular, 20:5 and 22:6 carbon polyunsaturated fatty acids were significantly elevated. Also, total plasma FFA level was elevated and FFA extraction ratios were increased as a result of prolonged starvation. Accumulation of 20- and 22-carbon polyunsaturated fatty acids observed in ventricles of starved rats may have resulted from increased availability and extraction of FFA.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7441376</pmid><doi>10.1093/jn/110.12.2490</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1980-12, Vol.110 (12), p.2490-2496 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Fatty Acids - metabolism Fatty Acids, Nonesterified - blood Fatty Acids, Nonesterified - metabolism Fatty Acids, Unsaturated - metabolism heart ventricle Heart Ventricles Humans Lipid Metabolism Myocardium - metabolism plasma fatty acids Rats starvation Starvation - metabolism |
| title | Effects of Prolonged Starvation on Plasma Free Fatty Acid Levels and Fatty Acid Composition of Myocardial Total Lipids in the Rat |
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