Studies on Tc-99m-Labeled Liver Ferritin: Hepatobiliary Behavior in Rats: Concise Communication
Ferritin was isolated from the livers of iron-loaded rats and labeled with Tc-99m. The radionuclide was found to be firmly bound to ferritin and essentially free of colloids. When injected into rats, about 65% of administered dose was found to be concentrated in the liver within 30 min. The blood ac...
Gespeichert in:
| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1980-12, Vol.21 (12), p.1177-1179 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1179 |
|---|---|
| container_issue | 12 |
| container_start_page | 1177 |
| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 21 |
| creator | Nadkarni, Ganeshsunder D Noronha, Oliver P. D Sewatkar, Arun B Deshpande, Usha R Ganatra, Ramnik D |
| description | Ferritin was isolated from the livers of iron-loaded rats and labeled with Tc-99m. The radionuclide was found to be firmly bound to ferritin and essentially free of colloids. When injected into rats, about 65% of administered dose was found to be concentrated in the liver within 30 min. The blood activity declined rapidly. Liver activity appeared to be excreted slowly through the hepatobiliary route, through there was 5 to 9% constant excretion through the kidneys. The results suggest that this labeled protein may prove useful as a hepatobiliary radiopharmaceutical. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_75359193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75359193</sourcerecordid><originalsourceid>FETCH-LOGICAL-h239t-63c54e2757e472d4a8cfc502546e0852a93f5f78e72ae59dad70226f798ef9143</originalsourceid><addsrcrecordid>eNotkF1LwzAYhYMoc05_gpAr8aaQjyZpdqfDqVAQdF6HLH1rM9p0Ju3Ef29lu3ouzsOBc87QnAouMiGlOkdzQiXNhCDiEl2ltCOEyKIoZmim8pxyIefIfAxj5SHhPuCNy7TustJuoYUKl_4AEa8hRj_4sMQvsLdDv_Wtt_EXP0JjD76P2Af8boe0xKs-OJ9gYteNwTs7-D5co4vatgluTlygz_XTZvWSlW_Pr6uHMmsY10MmuRM5MCUU5IpVuS1c7QRhIpdACsGs5rWoVQGKWRC6spUijMla6QJqTXO-QHfH3n3sv0dIg-l8ctC2NkA_JqOmVzTVfBJvT-K47aAy--i7aY85PTLl98e88V_Nj49gwuhasPFf3oWOUUOZoVQp_gc34GrK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75359193</pqid></control><display><type>article</type><title>Studies on Tc-99m-Labeled Liver Ferritin: Hepatobiliary Behavior in Rats: Concise Communication</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Nadkarni, Ganeshsunder D ; Noronha, Oliver P. D ; Sewatkar, Arun B ; Deshpande, Usha R ; Ganatra, Ramnik D</creator><creatorcontrib>Nadkarni, Ganeshsunder D ; Noronha, Oliver P. D ; Sewatkar, Arun B ; Deshpande, Usha R ; Ganatra, Ramnik D</creatorcontrib><description>Ferritin was isolated from the livers of iron-loaded rats and labeled with Tc-99m. The radionuclide was found to be firmly bound to ferritin and essentially free of colloids. When injected into rats, about 65% of administered dose was found to be concentrated in the liver within 30 min. The blood activity declined rapidly. Liver activity appeared to be excreted slowly through the hepatobiliary route, through there was 5 to 9% constant excretion through the kidneys. The results suggest that this labeled protein may prove useful as a hepatobiliary radiopharmaceutical.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 7441356</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Animals ; Biliary Tract - diagnostic imaging ; Biliary Tract - metabolism ; Female ; Ferritins - isolation & purification ; Ferritins - metabolism ; Intestines - metabolism ; Isotope Labeling ; Kidney - metabolism ; Liver - diagnostic imaging ; Liver - metabolism ; Mice ; Radionuclide Imaging ; Rats ; Technetium ; Time Factors</subject><ispartof>The Journal of nuclear medicine (1978), 1980-12, Vol.21 (12), p.1177-1179</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7441356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nadkarni, Ganeshsunder D</creatorcontrib><creatorcontrib>Noronha, Oliver P. D</creatorcontrib><creatorcontrib>Sewatkar, Arun B</creatorcontrib><creatorcontrib>Deshpande, Usha R</creatorcontrib><creatorcontrib>Ganatra, Ramnik D</creatorcontrib><title>Studies on Tc-99m-Labeled Liver Ferritin: Hepatobiliary Behavior in Rats: Concise Communication</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Ferritin was isolated from the livers of iron-loaded rats and labeled with Tc-99m. The radionuclide was found to be firmly bound to ferritin and essentially free of colloids. When injected into rats, about 65% of administered dose was found to be concentrated in the liver within 30 min. The blood activity declined rapidly. Liver activity appeared to be excreted slowly through the hepatobiliary route, through there was 5 to 9% constant excretion through the kidneys. The results suggest that this labeled protein may prove useful as a hepatobiliary radiopharmaceutical.</description><subject>Animals</subject><subject>Biliary Tract - diagnostic imaging</subject><subject>Biliary Tract - metabolism</subject><subject>Female</subject><subject>Ferritins - isolation & purification</subject><subject>Ferritins - metabolism</subject><subject>Intestines - metabolism</subject><subject>Isotope Labeling</subject><subject>Kidney - metabolism</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Radionuclide Imaging</subject><subject>Rats</subject><subject>Technetium</subject><subject>Time Factors</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkF1LwzAYhYMoc05_gpAr8aaQjyZpdqfDqVAQdF6HLH1rM9p0Ju3Ef29lu3ouzsOBc87QnAouMiGlOkdzQiXNhCDiEl2ltCOEyKIoZmim8pxyIefIfAxj5SHhPuCNy7TustJuoYUKl_4AEa8hRj_4sMQvsLdDv_Wtt_EXP0JjD76P2Af8boe0xKs-OJ9gYteNwTs7-D5co4vatgluTlygz_XTZvWSlW_Pr6uHMmsY10MmuRM5MCUU5IpVuS1c7QRhIpdACsGs5rWoVQGKWRC6spUijMla6QJqTXO-QHfH3n3sv0dIg-l8ctC2NkA_JqOmVzTVfBJvT-K47aAy--i7aY85PTLl98e88V_Nj49gwuhasPFf3oWOUUOZoVQp_gc34GrK</recordid><startdate>198012</startdate><enddate>198012</enddate><creator>Nadkarni, Ganeshsunder D</creator><creator>Noronha, Oliver P. D</creator><creator>Sewatkar, Arun B</creator><creator>Deshpande, Usha R</creator><creator>Ganatra, Ramnik D</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198012</creationdate><title>Studies on Tc-99m-Labeled Liver Ferritin: Hepatobiliary Behavior in Rats: Concise Communication</title><author>Nadkarni, Ganeshsunder D ; Noronha, Oliver P. D ; Sewatkar, Arun B ; Deshpande, Usha R ; Ganatra, Ramnik D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h239t-63c54e2757e472d4a8cfc502546e0852a93f5f78e72ae59dad70226f798ef9143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Biliary Tract - diagnostic imaging</topic><topic>Biliary Tract - metabolism</topic><topic>Female</topic><topic>Ferritins - isolation & purification</topic><topic>Ferritins - metabolism</topic><topic>Intestines - metabolism</topic><topic>Isotope Labeling</topic><topic>Kidney - metabolism</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - metabolism</topic><topic>Mice</topic><topic>Radionuclide Imaging</topic><topic>Rats</topic><topic>Technetium</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadkarni, Ganeshsunder D</creatorcontrib><creatorcontrib>Noronha, Oliver P. D</creatorcontrib><creatorcontrib>Sewatkar, Arun B</creatorcontrib><creatorcontrib>Deshpande, Usha R</creatorcontrib><creatorcontrib>Ganatra, Ramnik D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadkarni, Ganeshsunder D</au><au>Noronha, Oliver P. D</au><au>Sewatkar, Arun B</au><au>Deshpande, Usha R</au><au>Ganatra, Ramnik D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on Tc-99m-Labeled Liver Ferritin: Hepatobiliary Behavior in Rats: Concise Communication</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1980-12</date><risdate>1980</risdate><volume>21</volume><issue>12</issue><spage>1177</spage><epage>1179</epage><pages>1177-1179</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Ferritin was isolated from the livers of iron-loaded rats and labeled with Tc-99m. The radionuclide was found to be firmly bound to ferritin and essentially free of colloids. When injected into rats, about 65% of administered dose was found to be concentrated in the liver within 30 min. The blood activity declined rapidly. Liver activity appeared to be excreted slowly through the hepatobiliary route, through there was 5 to 9% constant excretion through the kidneys. The results suggest that this labeled protein may prove useful as a hepatobiliary radiopharmaceutical.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>7441356</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 1980-12, Vol.21 (12), p.1177-1179 |
| issn | 0161-5505 1535-5667 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75359193 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biliary Tract - diagnostic imaging Biliary Tract - metabolism Female Ferritins - isolation & purification Ferritins - metabolism Intestines - metabolism Isotope Labeling Kidney - metabolism Liver - diagnostic imaging Liver - metabolism Mice Radionuclide Imaging Rats Technetium Time Factors |
| title | Studies on Tc-99m-Labeled Liver Ferritin: Hepatobiliary Behavior in Rats: Concise Communication |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T03%3A54%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20on%20Tc-99m-Labeled%20Liver%20Ferritin:%20Hepatobiliary%20Behavior%20in%20Rats:%20Concise%20Communication&rft.jtitle=The%20Journal%20of%20nuclear%20medicine%20(1978)&rft.au=Nadkarni,%20Ganeshsunder%20D&rft.date=1980-12&rft.volume=21&rft.issue=12&rft.spage=1177&rft.epage=1179&rft.pages=1177-1179&rft.issn=0161-5505&rft.eissn=1535-5667&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E75359193%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75359193&rft_id=info:pmid/7441356&rfr_iscdi=true |