In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease
The effect on cell growth of bovine seminal RNase has been tested on cells cultured in vitro. A selective inhibition of growth has been observed on tumor cells as compared to normal cells using several virus-transformed cell lines and a neuroblastoma line. The different cellular response of virus-tr...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1980-10, Vol.40 (10), p.3740-3744 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | Vescia, S Tramontano, D Augusti-Tocco, G D'Alessio, G |
| description | The effect on cell growth of bovine seminal RNase has been tested on cells cultured in vitro. A selective inhibition of growth has been observed on tumor cells as compared to normal cells using several virus-transformed cell lines and a neuroblastoma line. The different cellular response of virus-transformed cells does not appear to depend on a differential permeability to the protein of transformed cells with respect to nontransformed ones. The selective cytotoxic action of seminal RNase on tumor cell growth was also compared with the action of other structurally related RNases and of various RNase derivatives prepared by specific chemical modifications. The results indicate that the protein dimeric structure and its enzymic activity are essential requirements for its action. |
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A selective inhibition of growth has been observed on tumor cells as compared to normal cells using several virus-transformed cell lines and a neuroblastoma line. The different cellular response of virus-transformed cells does not appear to depend on a differential permeability to the protein of transformed cells with respect to nontransformed ones. The selective cytotoxic action of seminal RNase on tumor cell growth was also compared with the action of other structurally related RNases and of various RNase derivatives prepared by specific chemical modifications. The results indicate that the protein dimeric structure and its enzymic activity are essential requirements for its action.</description><identifier>ISSN: 0008-5472</identifier><identifier>PMID: 7438057</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cell Count ; Cell Division - drug effects ; Cell Line ; Cell Transformation, Viral ; Cricetinae ; Kidney - metabolism ; Mesocricetus ; Mice ; Neoplasms, Experimental - pathology ; Neuroblastoma - pathology ; Pancreas - enzymology ; Ribonucleases - metabolism ; Ribonucleases - pharmacology ; Semen - enzymology</subject><ispartof>Cancer research (Chicago, Ill.), 1980-10, Vol.40 (10), p.3740-3744</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7438057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vescia, S</creatorcontrib><creatorcontrib>Tramontano, D</creatorcontrib><creatorcontrib>Augusti-Tocco, G</creatorcontrib><creatorcontrib>D'Alessio, G</creatorcontrib><title>In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>The effect on cell growth of bovine seminal RNase has been tested on cells cultured in vitro. A selective inhibition of growth has been observed on tumor cells as compared to normal cells using several virus-transformed cell lines and a neuroblastoma line. The different cellular response of virus-transformed cells does not appear to depend on a differential permeability to the protein of transformed cells with respect to nontransformed ones. The selective cytotoxic action of seminal RNase on tumor cell growth was also compared with the action of other structurally related RNases and of various RNase derivatives prepared by specific chemical modifications. The results indicate that the protein dimeric structure and its enzymic activity are essential requirements for its action.</description><subject>Animals</subject><subject>Cell Count</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Cell Transformation, Viral</subject><subject>Cricetinae</subject><subject>Kidney - metabolism</subject><subject>Mesocricetus</subject><subject>Mice</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neuroblastoma - pathology</subject><subject>Pancreas - enzymology</subject><subject>Ribonucleases - metabolism</subject><subject>Ribonucleases - pharmacology</subject><subject>Semen - enzymology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotUEtLxDAYzEFZ1-pPEHLyVvjyatqjLD4WFry455K0X22kbdYkXdl_b8WehhmGYWauyBYAylxJzW_IbYxfC1UM1IZstBQlKL0lx_1Ezy4FT2OaW4eR-olGHLBJ7ozUTb2zLrlF9B1N8-gDbXAY6GfwP6mn9rKYRzeZgQZn_TQ3A5qId-S6M0PE-xUzcnx5_ti95Yf31_3u6ZD3TKmUN7ZgbSdbzbuCF0YYVRWV1AVYMLY0QmDbAlcdAjMaFUAlWcO5KRhjlZaVyMjjf-4p-O8ZY6pHF__6mQn9HGuthARYxmbkYTXOdsS2PgU3mnCp1x_EL2crWLE</recordid><startdate>198010</startdate><enddate>198010</enddate><creator>Vescia, S</creator><creator>Tramontano, D</creator><creator>Augusti-Tocco, G</creator><creator>D'Alessio, G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198010</creationdate><title>In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease</title><author>Vescia, S ; Tramontano, D ; Augusti-Tocco, G ; D'Alessio, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h155t-cb61df4d72f626a3a59694760b0ab8a33edd025fe01a7e500941c22a611197493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Cell Count</topic><topic>Cell Division - drug effects</topic><topic>Cell Line</topic><topic>Cell Transformation, Viral</topic><topic>Cricetinae</topic><topic>Kidney - metabolism</topic><topic>Mesocricetus</topic><topic>Mice</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neuroblastoma - pathology</topic><topic>Pancreas - enzymology</topic><topic>Ribonucleases - metabolism</topic><topic>Ribonucleases - pharmacology</topic><topic>Semen - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vescia, S</creatorcontrib><creatorcontrib>Tramontano, D</creatorcontrib><creatorcontrib>Augusti-Tocco, G</creatorcontrib><creatorcontrib>D'Alessio, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vescia, S</au><au>Tramontano, D</au><au>Augusti-Tocco, G</au><au>D'Alessio, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1980-10</date><risdate>1980</risdate><volume>40</volume><issue>10</issue><spage>3740</spage><epage>3744</epage><pages>3740-3744</pages><issn>0008-5472</issn><abstract>The effect on cell growth of bovine seminal RNase has been tested on cells cultured in vitro. A selective inhibition of growth has been observed on tumor cells as compared to normal cells using several virus-transformed cell lines and a neuroblastoma line. The different cellular response of virus-transformed cells does not appear to depend on a differential permeability to the protein of transformed cells with respect to nontransformed ones. The selective cytotoxic action of seminal RNase on tumor cell growth was also compared with the action of other structurally related RNases and of various RNase derivatives prepared by specific chemical modifications. The results indicate that the protein dimeric structure and its enzymic activity are essential requirements for its action.</abstract><cop>United States</cop><pmid>7438057</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1980-10, Vol.40 (10), p.3740-3744 |
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| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cell Count Cell Division - drug effects Cell Line Cell Transformation, Viral Cricetinae Kidney - metabolism Mesocricetus Mice Neoplasms, Experimental - pathology Neuroblastoma - pathology Pancreas - enzymology Ribonucleases - metabolism Ribonucleases - pharmacology Semen - enzymology |
| title | In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease |
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