Nuclear changes induced in rat liver cells by thioacetamide
The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present...
Gespeichert in:
Veröffentlicht in: | Archives of biochemistry and biophysics 1953-09, Vol.46 (1), p.119-127 |
---|---|
1. Verfasser: | |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 127 |
---|---|
container_issue | 1 |
container_start_page | 119 |
container_title | Archives of biochemistry and biophysics |
container_volume | 46 |
creator | Laird, Anna Kane |
description | The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug. |
doi_str_mv | 10.1016/0003-9861(53)90175-1 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75333078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0003986153901751</els_id><sourcerecordid>75333078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rr6D0R6Ej1UJ02TTRAEWfyCRS96DmkzdSP90KRd2H9vyi568_QyzDMzyUPIKYUrClRcAwBLlRT0grNLBXTOU7pHphSUSIHJfJ9Mf5EJOQrhE4DSXGSHZEIZqEzxbEpuXoayRuOTcmXaDwyJa-1Qoo2ZeNMntVtjbGJdh6TYJP3KdabE3jTO4jE5qEwd8GSXM_L-cP-2eEqXr4_Pi7tlWjIBfZrHa0ZaY7gQPGe5yiqJhQRVxcqixVyayjLJjGDIlRKZ5AU3RtgCpBUVm5Hz7d4v330PGHrduDA-ybTYDUHPOWMM5jKC-RYsfReCx0p_edcYv9EU9ChNj0b0aETzmKM0TePY2W7_UDRo_4Z2liJwuwUw_nLt0OtQOmyjJuex7LXt3P8XfgAemHpX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75333078</pqid></control><display><type>article</type><title>Nuclear changes induced in rat liver cells by thioacetamide</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Laird, Anna Kane</creator><creatorcontrib>Laird, Anna Kane</creatorcontrib><description>The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1016/0003-9861(53)90175-1</identifier><identifier>PMID: 13092952</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Hepatocytes ; Liver - drug effects ; Old Medline ; Rats ; Thioacetamide</subject><ispartof>Archives of biochemistry and biophysics, 1953-09, Vol.46 (1), p.119-127</ispartof><rights>1953</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</citedby><cites>FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0003-9861(53)90175-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13092952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laird, Anna Kane</creatorcontrib><title>Nuclear changes induced in rat liver cells by thioacetamide</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug.</description><subject>Animals</subject><subject>Hepatocytes</subject><subject>Liver - drug effects</subject><subject>Old Medline</subject><subject>Rats</subject><subject>Thioacetamide</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1953</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0R6Ej1UJ02TTRAEWfyCRS96DmkzdSP90KRd2H9vyi568_QyzDMzyUPIKYUrClRcAwBLlRT0grNLBXTOU7pHphSUSIHJfJ9Mf5EJOQrhE4DSXGSHZEIZqEzxbEpuXoayRuOTcmXaDwyJa-1Qoo2ZeNMntVtjbGJdh6TYJP3KdabE3jTO4jE5qEwd8GSXM_L-cP-2eEqXr4_Pi7tlWjIBfZrHa0ZaY7gQPGe5yiqJhQRVxcqixVyayjLJjGDIlRKZ5AU3RtgCpBUVm5Hz7d4v330PGHrduDA-ybTYDUHPOWMM5jKC-RYsfReCx0p_edcYv9EU9ChNj0b0aETzmKM0TePY2W7_UDRo_4Z2liJwuwUw_nLt0OtQOmyjJuex7LXt3P8XfgAemHpX</recordid><startdate>195309</startdate><enddate>195309</enddate><creator>Laird, Anna Kane</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195309</creationdate><title>Nuclear changes induced in rat liver cells by thioacetamide</title><author>Laird, Anna Kane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1953</creationdate><topic>Animals</topic><topic>Hepatocytes</topic><topic>Liver - drug effects</topic><topic>Old Medline</topic><topic>Rats</topic><topic>Thioacetamide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laird, Anna Kane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laird, Anna Kane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuclear changes induced in rat liver cells by thioacetamide</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1953-09</date><risdate>1953</risdate><volume>46</volume><issue>1</issue><spage>119</spage><epage>127</epage><pages>119-127</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>13092952</pmid><doi>10.1016/0003-9861(53)90175-1</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0003-9861 |
ispartof | Archives of biochemistry and biophysics, 1953-09, Vol.46 (1), p.119-127 |
issn | 0003-9861 1096-0384 |
language | eng |
recordid | cdi_proquest_miscellaneous_75333078 |
source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Animals Hepatocytes Liver - drug effects Old Medline Rats Thioacetamide |
title | Nuclear changes induced in rat liver cells by thioacetamide |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T20%3A30%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nuclear%20changes%20induced%20in%20rat%20liver%20cells%20by%20thioacetamide&rft.jtitle=Archives%20of%20biochemistry%20and%20biophysics&rft.au=Laird,%20Anna%20Kane&rft.date=1953-09&rft.volume=46&rft.issue=1&rft.spage=119&rft.epage=127&rft.pages=119-127&rft.issn=0003-9861&rft.eissn=1096-0384&rft_id=info:doi/10.1016/0003-9861(53)90175-1&rft_dat=%3Cproquest_cross%3E75333078%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75333078&rft_id=info:pmid/13092952&rft_els_id=0003986153901751&rfr_iscdi=true |