Nuclear changes induced in rat liver cells by thioacetamide

The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Archives of biochemistry and biophysics 1953-09, Vol.46 (1), p.119-127
1. Verfasser: Laird, Anna Kane
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 127
container_issue 1
container_start_page 119
container_title Archives of biochemistry and biophysics
container_volume 46
creator Laird, Anna Kane
description The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug.
doi_str_mv 10.1016/0003-9861(53)90175-1
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75333078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0003986153901751</els_id><sourcerecordid>75333078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rr6D0R6Ej1UJ02TTRAEWfyCRS96DmkzdSP90KRd2H9vyi568_QyzDMzyUPIKYUrClRcAwBLlRT0grNLBXTOU7pHphSUSIHJfJ9Mf5EJOQrhE4DSXGSHZEIZqEzxbEpuXoayRuOTcmXaDwyJa-1Qoo2ZeNMntVtjbGJdh6TYJP3KdabE3jTO4jE5qEwd8GSXM_L-cP-2eEqXr4_Pi7tlWjIBfZrHa0ZaY7gQPGe5yiqJhQRVxcqixVyayjLJjGDIlRKZ5AU3RtgCpBUVm5Hz7d4v330PGHrduDA-ybTYDUHPOWMM5jKC-RYsfReCx0p_edcYv9EU9ChNj0b0aETzmKM0TePY2W7_UDRo_4Z2liJwuwUw_nLt0OtQOmyjJuex7LXt3P8XfgAemHpX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75333078</pqid></control><display><type>article</type><title>Nuclear changes induced in rat liver cells by thioacetamide</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Laird, Anna Kane</creator><creatorcontrib>Laird, Anna Kane</creatorcontrib><description>The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1016/0003-9861(53)90175-1</identifier><identifier>PMID: 13092952</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Hepatocytes ; Liver - drug effects ; Old Medline ; Rats ; Thioacetamide</subject><ispartof>Archives of biochemistry and biophysics, 1953-09, Vol.46 (1), p.119-127</ispartof><rights>1953</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</citedby><cites>FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0003-9861(53)90175-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13092952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laird, Anna Kane</creatorcontrib><title>Nuclear changes induced in rat liver cells by thioacetamide</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug.</description><subject>Animals</subject><subject>Hepatocytes</subject><subject>Liver - drug effects</subject><subject>Old Medline</subject><subject>Rats</subject><subject>Thioacetamide</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1953</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0R6Ej1UJ02TTRAEWfyCRS96DmkzdSP90KRd2H9vyi568_QyzDMzyUPIKYUrClRcAwBLlRT0grNLBXTOU7pHphSUSIHJfJ9Mf5EJOQrhE4DSXGSHZEIZqEzxbEpuXoayRuOTcmXaDwyJa-1Qoo2ZeNMntVtjbGJdh6TYJP3KdabE3jTO4jE5qEwd8GSXM_L-cP-2eEqXr4_Pi7tlWjIBfZrHa0ZaY7gQPGe5yiqJhQRVxcqixVyayjLJjGDIlRKZ5AU3RtgCpBUVm5Hz7d4v330PGHrduDA-ybTYDUHPOWMM5jKC-RYsfReCx0p_edcYv9EU9ChNj0b0aETzmKM0TePY2W7_UDRo_4Z2liJwuwUw_nLt0OtQOmyjJuex7LXt3P8XfgAemHpX</recordid><startdate>195309</startdate><enddate>195309</enddate><creator>Laird, Anna Kane</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195309</creationdate><title>Nuclear changes induced in rat liver cells by thioacetamide</title><author>Laird, Anna Kane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-4130a8daa566543492f8eb809f543dede48afd383a63e5996285b5aa6db08d6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1953</creationdate><topic>Animals</topic><topic>Hepatocytes</topic><topic>Liver - drug effects</topic><topic>Old Medline</topic><topic>Rats</topic><topic>Thioacetamide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laird, Anna Kane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laird, Anna Kane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuclear changes induced in rat liver cells by thioacetamide</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1953-09</date><risdate>1953</risdate><volume>46</volume><issue>1</issue><spage>119</spage><epage>127</epage><pages>119-127</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>The observation by Rather (1) that thioacetamide induces a stepwise increase in hepatic nuclear volumes, in powers of two, accompanied by great increases in nucleolar and cytoplasmic volumes, suggested the possibility that this drug might be useful for the study of nuclear physiology. In the present study it has been demonstrated that the changes in nuclear volume induced by thioacetamide under the present conditions are not due to polyploidy, since the desoxyribonucleic acid content of the average nucleus did not change from the normal control level. However, great increases in both protein and ribonucleic acid of the average nucleus do accompany the administration of the drug.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>13092952</pmid><doi>10.1016/0003-9861(53)90175-1</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0003-9861
ispartof Archives of biochemistry and biophysics, 1953-09, Vol.46 (1), p.119-127
issn 0003-9861
1096-0384
language eng
recordid cdi_proquest_miscellaneous_75333078
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Animals
Hepatocytes
Liver - drug effects
Old Medline
Rats
Thioacetamide
title Nuclear changes induced in rat liver cells by thioacetamide
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T20%3A30%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nuclear%20changes%20induced%20in%20rat%20liver%20cells%20by%20thioacetamide&rft.jtitle=Archives%20of%20biochemistry%20and%20biophysics&rft.au=Laird,%20Anna%20Kane&rft.date=1953-09&rft.volume=46&rft.issue=1&rft.spage=119&rft.epage=127&rft.pages=119-127&rft.issn=0003-9861&rft.eissn=1096-0384&rft_id=info:doi/10.1016/0003-9861(53)90175-1&rft_dat=%3Cproquest_cross%3E75333078%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75333078&rft_id=info:pmid/13092952&rft_els_id=0003986153901751&rfr_iscdi=true