Increased Production of Prostaglandin D2 in Patients with Systemic Mastocytosis
SYSTEMIC mastocytosis is a disorder of unknown origin, characterized by abnormal proliferation of tissue mast cells involving various organs and associated with a variety of clinical symptoms and signs. 1 Episodic attacks of flushing, frequently accompanied by hypotension and tachycardia, are a pred...
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| Veröffentlicht in: | The New England journal of medicine 1980-12, Vol.303 (24), p.1400-1404 |
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| container_title | The New England journal of medicine |
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| creator | Roberts, L. Jackson Sweetman, Brian J Lewis, Robert A Austen, K. Frank Oates, John A |
| description | SYSTEMIC mastocytosis is a disorder of unknown origin, characterized by abnormal proliferation of tissue mast cells involving various organs and associated with a variety of clinical symptoms and signs.
1
Episodic attacks of flushing, frequently accompanied by hypotension and tachycardia, are a predominant manifestation of systemic mastocytosis, which at times can result in life-threatening shock.
Although the symptoms of mastocytosis have generally been attributed to the release of histamine from mast cells, only partial amelioration of symptoms has been described in the few isolated case reports on the effects of histamine-antagonist therapy of this disorder.
2
,
3
After the recent demonstration that combined . . . |
| doi_str_mv | 10.1056/NEJM198012113032405 |
| format | Article |
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1
Episodic attacks of flushing, frequently accompanied by hypotension and tachycardia, are a predominant manifestation of systemic mastocytosis, which at times can result in life-threatening shock.
Although the symptoms of mastocytosis have generally been attributed to the release of histamine from mast cells, only partial amelioration of symptoms has been described in the few isolated case reports on the effects of histamine-antagonist therapy of this disorder.
2
,
3
After the recent demonstration that combined . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198012113032405</identifier><identifier>PMID: 6107852</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acids ; Adult ; Animals ; Aspirin - administration & dosage ; Aspirin - therapeutic use ; Biopsy ; Cardiac arrhythmia ; Case reports ; Chromatography ; Dyspnea ; Female ; Histamine ; Histamine H1 Antagonists - therapeutic use ; Histamine H2 Antagonists - therapeutic use ; Humans ; Male ; Mast Cells - metabolism ; Mastocytosis ; Middle Aged ; Pathogenesis ; Patients ; Primates ; Prostaglandin D2 ; Prostaglandins - biosynthesis ; Prostaglandins D - biosynthesis ; Prostaglandins D - urine ; Pruritus ; Retention ; Urine ; Urticaria Pigmentosa - drug therapy ; Urticaria Pigmentosa - metabolism ; Urticaria Pigmentosa - physiopathology</subject><ispartof>The New England journal of medicine, 1980-12, Vol.303 (24), p.1400-1404</ispartof><rights>Copyright Massachusetts Medical Society Dec 11, 1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-7ef8da0b3ec2550dcf075a673148e67d82a1d1ce236dbe394f12a3748ecc1f8b2</citedby><cites>FETCH-LOGICAL-c364t-7ef8da0b3ec2550dcf075a673148e67d82a1d1ce236dbe394f12a3748ecc1f8b2</cites></display><links><openurl>$$Topenurl_article</openurl><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6107852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, L. Jackson</creatorcontrib><creatorcontrib>Sweetman, Brian J</creatorcontrib><creatorcontrib>Lewis, Robert A</creatorcontrib><creatorcontrib>Austen, K. Frank</creatorcontrib><creatorcontrib>Oates, John A</creatorcontrib><title>Increased Production of Prostaglandin D2 in Patients with Systemic Mastocytosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>SYSTEMIC mastocytosis is a disorder of unknown origin, characterized by abnormal proliferation of tissue mast cells involving various organs and associated with a variety of clinical symptoms and signs.
1
Episodic attacks of flushing, frequently accompanied by hypotension and tachycardia, are a predominant manifestation of systemic mastocytosis, which at times can result in life-threatening shock.
Although the symptoms of mastocytosis have generally been attributed to the release of histamine from mast cells, only partial amelioration of symptoms has been described in the few isolated case reports on the effects of histamine-antagonist therapy of this disorder.
2
,
3
After the recent demonstration that combined . . .</description><subject>Acids</subject><subject>Adult</subject><subject>Animals</subject><subject>Aspirin - administration & dosage</subject><subject>Aspirin - therapeutic use</subject><subject>Biopsy</subject><subject>Cardiac arrhythmia</subject><subject>Case reports</subject><subject>Chromatography</subject><subject>Dyspnea</subject><subject>Female</subject><subject>Histamine</subject><subject>Histamine H1 Antagonists - therapeutic use</subject><subject>Histamine H2 Antagonists - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Mast Cells - metabolism</subject><subject>Mastocytosis</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Primates</subject><subject>Prostaglandin D2</subject><subject>Prostaglandins - biosynthesis</subject><subject>Prostaglandins D - biosynthesis</subject><subject>Prostaglandins D - urine</subject><subject>Pruritus</subject><subject>Retention</subject><subject>Urine</subject><subject>Urticaria Pigmentosa - drug therapy</subject><subject>Urticaria Pigmentosa - metabolism</subject><subject>Urticaria Pigmentosa - physiopathology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>false</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UE1Lw0AQXUSptfoLRAgIXiS6s985Sq1aaW1BPYft7kZTmkSzG6T_3i0tHkScwwzDe_N48xA6BXwFmIvrp9HjFDKFgQBQTAnDfA_1gVOaMobFPupjTFTKZEYP0ZH3SxwLWNZDPQFYKk76aDauTeu0dzaZt43tTCibOmmKzeaDflvp2pZ1ckuS2Oc6lK4OPvkqw3vyvPbBVaVJptqHxqxD40t_jA4KvfLuZDcH6PVu9DJ8SCez-_HwZpIaKlhIpSuU1XhBnSGcY2sKLLkWkgJTTkiriAYLxhEq7MLRjBVANJURNAYKtSADdLHV_Wibz875kFelN24V_bqm87nklChgOBLPfxGXTdfW0VsOSmRcUalYZNEty8S3feuK_KMtK92uc8D5Juz8j7Dj1dlOu1tUzv7c7NKN-OUWryqf125Z_av2DauAhaA</recordid><startdate>19801211</startdate><enddate>19801211</enddate><creator>Roberts, L. Jackson</creator><creator>Sweetman, Brian J</creator><creator>Lewis, Robert A</creator><creator>Austen, K. 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Jackson ; Sweetman, Brian J ; Lewis, Robert A ; Austen, K. Frank ; Oates, John A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-7ef8da0b3ec2550dcf075a673148e67d82a1d1ce236dbe394f12a3748ecc1f8b2</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Animals</topic><topic>Aspirin - administration & dosage</topic><topic>Aspirin - therapeutic use</topic><topic>Biopsy</topic><topic>Cardiac arrhythmia</topic><topic>Case reports</topic><topic>Chromatography</topic><topic>Dyspnea</topic><topic>Female</topic><topic>Histamine</topic><topic>Histamine H1 Antagonists - therapeutic use</topic><topic>Histamine H2 Antagonists - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Mast Cells - metabolism</topic><topic>Mastocytosis</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Primates</topic><topic>Prostaglandin D2</topic><topic>Prostaglandins - biosynthesis</topic><topic>Prostaglandins D - biosynthesis</topic><topic>Prostaglandins D - urine</topic><topic>Pruritus</topic><topic>Retention</topic><topic>Urine</topic><topic>Urticaria Pigmentosa - drug therapy</topic><topic>Urticaria Pigmentosa - metabolism</topic><topic>Urticaria Pigmentosa - physiopathology</topic><toplevel>peer_reviewed</toplevel><creatorcontrib>Roberts, L. Jackson</creatorcontrib><creatorcontrib>Sweetman, Brian J</creatorcontrib><creatorcontrib>Lewis, Robert A</creatorcontrib><creatorcontrib>Austen, K. 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Jackson</au><au>Sweetman, Brian J</au><au>Lewis, Robert A</au><au>Austen, K. Frank</au><au>Oates, John A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Production of Prostaglandin D2 in Patients with Systemic Mastocytosis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1980-12-11</date><risdate>1980</risdate><volume>303</volume><issue>24</issue><spage>1400</spage><epage>1404</epage><pages>1400-1404</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>SYSTEMIC mastocytosis is a disorder of unknown origin, characterized by abnormal proliferation of tissue mast cells involving various organs and associated with a variety of clinical symptoms and signs.
1
Episodic attacks of flushing, frequently accompanied by hypotension and tachycardia, are a predominant manifestation of systemic mastocytosis, which at times can result in life-threatening shock.
Although the symptoms of mastocytosis have generally been attributed to the release of histamine from mast cells, only partial amelioration of symptoms has been described in the few isolated case reports on the effects of histamine-antagonist therapy of this disorder.
2
,
3
After the recent demonstration that combined . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>6107852</pmid><doi>10.1056/NEJM198012113032405</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1980-12, Vol.303 (24), p.1400-1404 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE |
| subjects | Acids Adult Animals Aspirin - administration & dosage Aspirin - therapeutic use Biopsy Cardiac arrhythmia Case reports Chromatography Dyspnea Female Histamine Histamine H1 Antagonists - therapeutic use Histamine H2 Antagonists - therapeutic use Humans Male Mast Cells - metabolism Mastocytosis Middle Aged Pathogenesis Patients Primates Prostaglandin D2 Prostaglandins - biosynthesis Prostaglandins D - biosynthesis Prostaglandins D - urine Pruritus Retention Urine Urticaria Pigmentosa - drug therapy Urticaria Pigmentosa - metabolism Urticaria Pigmentosa - physiopathology |
| title | Increased Production of Prostaglandin D2 in Patients with Systemic Mastocytosis |
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