In vivo effects of human dialyzable leukocyte lysates : II. Augmentation of the spleen cell proliferative response to antigen in KLH-sensitive mice
The in vivo effects of human dialyzable leukocyte lysate (DLL) upon the subsequent in vitro proliferative response of lymphocytes to antigen was investigated. Twenty-four-hour DLL treatment of KLH-sensitive mice resulted in the augmentation of antigen-stimulated proliferation of 5-day spleen cell cu...
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| Veröffentlicht in: | Cellular immunology 1980-11, Vol.56 (1), p.120-131 |
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| container_title | Cellular immunology |
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| creator | Schindler, Thomas E. Baram, Peter |
| description | The
in vivo effects of human dialyzable leukocyte lysate (DLL) upon the subsequent
in vitro proliferative response of lymphocytes to antigen was investigated. Twenty-four-hour DLL treatment of KLH-sensitive mice resulted in the augmentation of antigen-stimulated proliferation of 5-day spleen cell cultures. Ampliative effects of DLL treatment were dependent upon the time after antigen priming and the conditions of sensitization. Moderate augmentation was detected 1–4 weeks following suboptimal sensitization. Marked enhancement of the response to antigen was observed in optimally sensitized mice only after the initial proliferation had subsided. DLL augmentation was detected more readily in mice primed with optimal concentration of antigen than in mice sensitized with lower concentrations of KLH. |
| doi_str_mv | 10.1016/0008-8749(80)90087-8 |
| format | Article |
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in vivo effects of human dialyzable leukocyte lysate (DLL) upon the subsequent
in vitro proliferative response of lymphocytes to antigen was investigated. Twenty-four-hour DLL treatment of KLH-sensitive mice resulted in the augmentation of antigen-stimulated proliferation of 5-day spleen cell cultures. Ampliative effects of DLL treatment were dependent upon the time after antigen priming and the conditions of sensitization. Moderate augmentation was detected 1–4 weeks following suboptimal sensitization. Marked enhancement of the response to antigen was observed in optimally sensitized mice only after the initial proliferation had subsided. DLL augmentation was detected more readily in mice primed with optimal concentration of antigen than in mice sensitized with lower concentrations of KLH.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/0008-8749(80)90087-8</identifier><identifier>PMID: 7428054</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Antigens - immunology ; Cell Division ; Dialysis ; Female ; Hemocyanins - immunology ; Humans ; Immunization ; Leukocytes - immunology ; Mice ; Mice, Inbred C57BL - immunology ; Spleen - cytology</subject><ispartof>Cellular immunology, 1980-11, Vol.56 (1), p.120-131</ispartof><rights>1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0008-8749(80)90087-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7428054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schindler, Thomas E.</creatorcontrib><creatorcontrib>Baram, Peter</creatorcontrib><title>In vivo effects of human dialyzable leukocyte lysates : II. Augmentation of the spleen cell proliferative response to antigen in KLH-sensitive mice</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>The
in vivo effects of human dialyzable leukocyte lysate (DLL) upon the subsequent
in vitro proliferative response of lymphocytes to antigen was investigated. Twenty-four-hour DLL treatment of KLH-sensitive mice resulted in the augmentation of antigen-stimulated proliferation of 5-day spleen cell cultures. Ampliative effects of DLL treatment were dependent upon the time after antigen priming and the conditions of sensitization. Moderate augmentation was detected 1–4 weeks following suboptimal sensitization. Marked enhancement of the response to antigen was observed in optimally sensitized mice only after the initial proliferation had subsided. DLL augmentation was detected more readily in mice primed with optimal concentration of antigen than in mice sensitized with lower concentrations of KLH.</description><subject>Animals</subject><subject>Antigens - immunology</subject><subject>Cell Division</subject><subject>Dialysis</subject><subject>Female</subject><subject>Hemocyanins - immunology</subject><subject>Humans</subject><subject>Immunization</subject><subject>Leukocytes - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL - immunology</subject><subject>Spleen - cytology</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kcFO3DAQhi3UChbaN6CSTxU9hI4TJ3F6QEKolFVX6oWeLcceg0tib2NnpeU1eOE6sOppZvR_M_o1PyHnDC4ZsOYrAIhCtLy7EPCly0NbiCOyYtBBUbKmekdW_5ETchrjHwDGeAfH5LjlpYCar8jL2tOd2wWK1qJOkQZLH-dReWqcGvbPqh-QDjg_Bb1PudtHlTDSb3S9vqTX88OIPqnkgl8W0yPSuB0QPdU4DHQ7hcFZnDKwQzph3AYfkaZAlU_uIWPO05-buyKij-4VGp3GD-S9VUPEj4d6Rn7ffr-_uSs2v36sb643BbK2SYU1XdkLq1GDRlZbg4DMtFzUFnqla9ZwbioLjW6ghKbUtjFW8L6GCoTqTXVGPr_dzT7_zhiTHF1cjCuPYY6yrSvgJYcMfjqAcz-ikdvJjWray8MXs371pmN2u3M4yagdeo3GTfmp0gQnGcglNblEIpdIpAD5mpoU1T9w0It-</recordid><startdate>198011</startdate><enddate>198011</enddate><creator>Schindler, Thomas E.</creator><creator>Baram, Peter</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198011</creationdate><title>In vivo effects of human dialyzable leukocyte lysates : II. Augmentation of the spleen cell proliferative response to antigen in KLH-sensitive mice</title><author>Schindler, Thomas E. ; Baram, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e176t-fd92b8fcec0ce15fde0e1d7485f0bac51644d3f06c602062cf6df84b50308abd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Antigens - immunology</topic><topic>Cell Division</topic><topic>Dialysis</topic><topic>Female</topic><topic>Hemocyanins - immunology</topic><topic>Humans</topic><topic>Immunization</topic><topic>Leukocytes - immunology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL - immunology</topic><topic>Spleen - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schindler, Thomas E.</creatorcontrib><creatorcontrib>Baram, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schindler, Thomas E.</au><au>Baram, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo effects of human dialyzable leukocyte lysates : II. Augmentation of the spleen cell proliferative response to antigen in KLH-sensitive mice</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1980-11</date><risdate>1980</risdate><volume>56</volume><issue>1</issue><spage>120</spage><epage>131</epage><pages>120-131</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>The
in vivo effects of human dialyzable leukocyte lysate (DLL) upon the subsequent
in vitro proliferative response of lymphocytes to antigen was investigated. Twenty-four-hour DLL treatment of KLH-sensitive mice resulted in the augmentation of antigen-stimulated proliferation of 5-day spleen cell cultures. Ampliative effects of DLL treatment were dependent upon the time after antigen priming and the conditions of sensitization. Moderate augmentation was detected 1–4 weeks following suboptimal sensitization. Marked enhancement of the response to antigen was observed in optimally sensitized mice only after the initial proliferation had subsided. DLL augmentation was detected more readily in mice primed with optimal concentration of antigen than in mice sensitized with lower concentrations of KLH.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>7428054</pmid><doi>10.1016/0008-8749(80)90087-8</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cellular immunology, 1980-11, Vol.56 (1), p.120-131 |
| issn | 0008-8749 1090-2163 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75304240 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antigens - immunology Cell Division Dialysis Female Hemocyanins - immunology Humans Immunization Leukocytes - immunology Mice Mice, Inbred C57BL - immunology Spleen - cytology |
| title | In vivo effects of human dialyzable leukocyte lysates : II. Augmentation of the spleen cell proliferative response to antigen in KLH-sensitive mice |
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