THE MODE OF ACTION OF NANAOMYCIN A IN GRAM-POSITIVE BACTERIA
The mode of action of nanaomycin A on Gram-positive bacteria such as Staphylococcus aureus, Bacillus cereus and Streptococcus faecalis was investigated. Nanaomycin A inhibited the biosyntheses of protein, DNA, RNA and cell-wall peptidoglycan to a similar extent. It increased the exogenous respiratio...
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| Veröffentlicht in: | Journal of antibiotics 1980, Vol.33(8), pp.885-890 |
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| container_end_page | 890 |
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| container_issue | 8 |
| container_start_page | 885 |
| container_title | Journal of antibiotics |
| container_volume | 33 |
| creator | MARUMO, HIROFUTO KITAURA, KOZO MORIMOTO, MAKOTO TANAKA, HARUO OMURA, SATOSHI |
| description | The mode of action of nanaomycin A on Gram-positive bacteria such as Staphylococcus aureus, Bacillus cereus and Streptococcus faecalis was investigated. Nanaomycin A inhibited the biosyntheses of protein, DNA, RNA and cell-wall peptidoglycan to a similar extent. It increased the exogenous respiration of S. aureus cells at the minimal inhibitory concentration. The cells preincubated with nanaomycin A showed stimulation of proton influx after addition of N, N'-dicyclo-hexylcarbodiimide, an inhibitor of Ca++ Mg++-ATPase. Nanaomycin A seems to interfere with the cytoplasmic membrane or to inhibit coupling of oxidative phosphorylation, followed by secondary inhibitory effect on protein, nucleic acids and cell-wall peptidoglycan biosyntheses. |
| doi_str_mv | 10.7164/antibiotics.33.885 |
| format | Article |
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Nanaomycin A inhibited the biosyntheses of protein, DNA, RNA and cell-wall peptidoglycan to a similar extent. It increased the exogenous respiration of S. aureus cells at the minimal inhibitory concentration. The cells preincubated with nanaomycin A showed stimulation of proton influx after addition of N, N'-dicyclo-hexylcarbodiimide, an inhibitor of Ca++ Mg++-ATPase. 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Antibiot.</addtitle><description>The mode of action of nanaomycin A on Gram-positive bacteria such as Staphylococcus aureus, Bacillus cereus and Streptococcus faecalis was investigated. Nanaomycin A inhibited the biosyntheses of protein, DNA, RNA and cell-wall peptidoglycan to a similar extent. It increased the exogenous respiration of S. aureus cells at the minimal inhibitory concentration. The cells preincubated with nanaomycin A showed stimulation of proton influx after addition of N, N'-dicyclo-hexylcarbodiimide, an inhibitor of Ca++ Mg++-ATPase. 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Antibiot.</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>33</volume><issue>8</issue><spage>885</spage><epage>890</epage><pages>885-890</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The mode of action of nanaomycin A on Gram-positive bacteria such as Staphylococcus aureus, Bacillus cereus and Streptococcus faecalis was investigated. Nanaomycin A inhibited the biosyntheses of protein, DNA, RNA and cell-wall peptidoglycan to a similar extent. It increased the exogenous respiration of S. aureus cells at the minimal inhibitory concentration. The cells preincubated with nanaomycin A showed stimulation of proton influx after addition of N, N'-dicyclo-hexylcarbodiimide, an inhibitor of Ca++ Mg++-ATPase. 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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1980, Vol.33(8), pp.885-890 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Anti-Bacterial Agents - pharmacology Bacteria - drug effects Bacteria - growth & development Bacteria - metabolism Bacterial Proteins - biosynthesis DNA, Bacterial - biosynthesis Naphthoquinones - pharmacology Oxygen Consumption - drug effects Protons RNA, Bacterial - biosynthesis |
| title | THE MODE OF ACTION OF NANAOMYCIN A IN GRAM-POSITIVE BACTERIA |
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