Effects of second-generation platinum analogs on isolated PM-2 DNA and their cytotoxicity in vitro and in vivo

Using PM-2 DNA and cytotoxicity assay systems, we have studied several second-generation platinum analogs and compared these to the parent compound cis-diamminedichloroplatinum(II). These results indicate that all planar platinum(II) congeners induced similar effects upon interaction with PM-2 DNA,...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1980-09, Vol.40 (9), p.3318-3324
Hauptverfasser:	Mong, S, Huang, C H, Prestayko, A W, Crooke, S T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cell Line Cell Survival Chemical Phenomena Chemistry Cisplatin - metabolism Cisplatin - pharmacology DNA, Circular - metabolism DNA, Superhelical - metabolism DNA, Viral - isolation & purification DNA, Viral - metabolism Electrophoresis, Agar Gel Isomerism Liver Neoplasms, Experimental - metabolism Nucleic Acid Conformation - drug effects Organoplatinum Compounds - metabolism Organoplatinum Compounds - pharmacology Plasmids Structure-Activity Relationship
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