Irreversible inhibition of aromatic- l-amino acid decarboxylase by α-difluoromethyl-DOPA and metabolism of the inhibitor

In vitro, α-difluoromethyl DOPA (DFMD, RMI 71801), at concentrations from 2 to 20 μM, inhibits aromatic- L-amino acid decarboxylase (AADC) in a time-dependent manner. After inhibition, the activity of the enzyme cannot be restored by dialysis. The inhibition is prevented by addition of an excess of...

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Veröffentlicht in:	Biochemical pharmacology 1980-01, Vol.29 (18), p.2465-2469
Hauptverfasser:	Ribéreau-Gayon, G., Palfreyman, M.G., Zraïka, M., Wagner, J., Jung, M.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatic Amino Acid Decarboxylase Inhibitors Catechol O-Methyltransferase - metabolism Dihydroxyphenylalanine - analogs & derivatives Kidney - enzymology Levodopa - pharmacology Methylation Methyldopa - analogs & derivatives Methyldopa - metabolism Methyldopa - pharmacology Pyridoxal Phosphate - pharmacology Rats Swine
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