Persistent effects of chronic administration of LSD on intracellular serotonin content in rat midbrain
The effects of acute and chronic administration of LSD on the intracellular serotonin content of raphe neurons in rat midbrain were compared using a cytofluorimetric measure of serotonin based on fluorescence fading. Consistent with previous reports, acute treatment with LSD preferentially increased...
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| Veröffentlicht in: | Neuropharmacology 1980-10, Vol.19 (10), p.1005-1007 |
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| container_title | Neuropharmacology |
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| creator | Lee, E.H.Y. Geyer, M.A. |
| description | The effects of acute and chronic administration of LSD on the intracellular serotonin content of raphe neurons in rat midbrain were compared using a cytofluorimetric measure of serotonin based on fluorescence fading. Consistent with previous reports, acute treatment with LSD preferentially increased intracellular serotonin levels in both the dorsal and median raphe nuclei. Similar increases in serotonin were observed following 14 daily injections of LSD and 24 hr after the last of 13 daily injections. No significant differences were found between the effects of acute and chronic LSD treatments on any of the cytofluorimetric measures of serotonin. Together with the results from previous electro-physiological and behavioral studies, these findings indicate that little or no tolerance occurs to the effects of LSD on serotonergic neurons. |
| doi_str_mv | 10.1016/0028-3908(80)90012-X |
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Consistent with previous reports, acute treatment with LSD preferentially increased intracellular serotonin levels in both the dorsal and median raphe nuclei. Similar increases in serotonin were observed following 14 daily injections of LSD and 24 hr after the last of 13 daily injections. No significant differences were found between the effects of acute and chronic LSD treatments on any of the cytofluorimetric measures of serotonin. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Lysergic Acid Diethylamide - pharmacology Male Mesencephalon - drug effects Mesencephalon - metabolism Raphe Nuclei - metabolism Rats Serotonin - metabolism |
| title | Persistent effects of chronic administration of LSD on intracellular serotonin content in rat midbrain |
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