Prognostic indicators in induction cis-platinum bleomycin chemotherapy for advanced head and neck cancer
A complete response to induction cis-platinum bleomycin chemotherapy significantly increases the probability of local tumor control and overall disease-free survival. Factors that favor a good response to chemotherapy are tumor histology (well differentiated), location of the primary site (oral cavi...
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| Veröffentlicht in: | The American journal of surgery 1980-10, Vol.140 (4), p.543-548 |
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| container_issue | 4 |
| container_start_page | 543 |
| container_title | The American journal of surgery |
| container_volume | 140 |
| creator | Shapshay, Stanley M. Hong, Waun Ki Incze, Joseph S. Sismanis, Aristides Bhutani, Rakesh Vaughn, Charles W. Strong, M.Stuart |
| description | A complete response to induction cis-platinum bleomycin chemotherapy significantly increases the probability of local tumor control and overall disease-free survival. Factors that favor a good response to chemotherapy are tumor histology (well differentiated), location of the primary site (oral cavity and oropharynx), nodal status (N
0) and size of the primary lesion (T
3 better than T
4). Increased cellular maturation after chemotherapy correlates with an improved clinical response. The importance of induction and maintenance chemotherapy in the treatment of advanced head and neck cancer still needs to be determined with larger randomized series. Reliable predictors of therapy outcome are needed for realistic treatment planning, especially when the potential morbidity is considered. |
| doi_str_mv | 10.1016/0002-9610(80)90208-1 |
| format | Article |
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3 better than T
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0) and size of the primary lesion (T
3 better than T
4). Increased cellular maturation after chemotherapy correlates with an improved clinical response. The importance of induction and maintenance chemotherapy in the treatment of advanced head and neck cancer still needs to be determined with larger randomized series. Reliable predictors of therapy outcome are needed for realistic treatment planning, especially when the potential morbidity is considered.</description><subject>Bleomycin - administration & dosage</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Cisplatin - administration & dosage</subject><subject>Drug Therapy, Combination</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Prognosis</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQQK0KRBfaf0AlnxAcQsd2PpxLJYSgIK3UHtqz5YwnXUMSb-1kpf33TdgVx57smXkzo3mMXQq4FSDKrwAgs7oUcK3hpgYJOhMf2Eroqs6E1uqErd6Rj-w8pZc5FCJXZ-ysFIWekRXb_IzhzxDS6JH7wXm0Y4hp_i7RhKMPA0efsm1nRz9MPW86Cv0eZwA31IdxQ9Fu97wNkVu3swOS4xuyjtvB8YHwleOSjJ_YaWu7RJ-P7wX7_fjw6_4pW__4_nx_t85QFdWY5da1dS2VJKlKB9Zp16hWCagcEFghpGxUnbclSK00uKaipipKgVhUFdaFumBXh7nbGP5OlEbT-4TUdXagMCVTFVLXKtczmB9AjCGlSK3ZRt_buDcCzCLYLPbMYs9oMG-CjZjbvhznT01P7r3paHSufzvUaT5y5ymahJ4WLT4SjsYF__8F_wCOL4sJ</recordid><startdate>198010</startdate><enddate>198010</enddate><creator>Shapshay, Stanley M.</creator><creator>Hong, Waun Ki</creator><creator>Incze, Joseph S.</creator><creator>Sismanis, Aristides</creator><creator>Bhutani, Rakesh</creator><creator>Vaughn, Charles W.</creator><creator>Strong, M.Stuart</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198010</creationdate><title>Prognostic indicators in induction cis-platinum bleomycin chemotherapy for advanced head and neck cancer</title><author>Shapshay, Stanley M. ; Hong, Waun Ki ; Incze, Joseph S. ; Sismanis, Aristides ; Bhutani, Rakesh ; Vaughn, Charles W. ; Strong, M.Stuart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4adf99232e236d0ad8db3f3107d0e0a1122b394f6028380db7eb7561cc577c953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Bleomycin - administration & dosage</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Cisplatin - administration & dosage</topic><topic>Drug Therapy, Combination</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shapshay, Stanley M.</creatorcontrib><creatorcontrib>Hong, Waun Ki</creatorcontrib><creatorcontrib>Incze, Joseph S.</creatorcontrib><creatorcontrib>Sismanis, Aristides</creatorcontrib><creatorcontrib>Bhutani, Rakesh</creatorcontrib><creatorcontrib>Vaughn, Charles W.</creatorcontrib><creatorcontrib>Strong, M.Stuart</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shapshay, Stanley M.</au><au>Hong, Waun Ki</au><au>Incze, Joseph S.</au><au>Sismanis, Aristides</au><au>Bhutani, Rakesh</au><au>Vaughn, Charles W.</au><au>Strong, M.Stuart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic indicators in induction cis-platinum bleomycin chemotherapy for advanced head and neck cancer</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1980-10</date><risdate>1980</risdate><volume>140</volume><issue>4</issue><spage>543</spage><epage>548</epage><pages>543-548</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>A complete response to induction cis-platinum bleomycin chemotherapy significantly increases the probability of local tumor control and overall disease-free survival. Factors that favor a good response to chemotherapy are tumor histology (well differentiated), location of the primary site (oral cavity and oropharynx), nodal status (N
0) and size of the primary lesion (T
3 better than T
4). Increased cellular maturation after chemotherapy correlates with an improved clinical response. The importance of induction and maintenance chemotherapy in the treatment of advanced head and neck cancer still needs to be determined with larger randomized series. Reliable predictors of therapy outcome are needed for realistic treatment planning, especially when the potential morbidity is considered.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6158883</pmid><doi>10.1016/0002-9610(80)90208-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of surgery, 1980-10, Vol.140 (4), p.543-548 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bleomycin - administration & dosage Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - therapy Cisplatin - administration & dosage Drug Therapy, Combination Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - therapy Humans Prognosis |
| title | Prognostic indicators in induction cis-platinum bleomycin chemotherapy for advanced head and neck cancer |
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