Leukocyte ascorbic acid and its relationship to coronary artery disease in man
The ascorbic acid level of the leukocytes in patients with coronary artery disease was compared to the ascorbic acid level of the leukocytes in patients without coronary artery disease as demonstrated by coronary arteriography. The leukocyte ascorbic acid level was found significantly lower in patie...
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| Veröffentlicht in: | The American journal of clinical nutrition 1980-10, Vol.33 (10), p.2079-2087 |
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| container_end_page | 2087 |
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| container_title | The American journal of clinical nutrition |
| container_volume | 33 |
| creator | Ramirez, J Flowers, N C |
| description | The ascorbic acid level of the leukocytes in patients with coronary artery disease was compared to the ascorbic acid level of the leukocytes in patients without coronary artery disease as demonstrated by coronary arteriography. The leukocyte ascorbic acid level was found significantly lower in patients with coronary atherosclerosis (P < 0.001). There was also significant difference in the leukocyte ascorbic acid levels among patients with abnormal coronary arteriograms who smoked compared to those who did not. The anatomical changes secondary to atherosclerotic disease, and mainly those changes related to the ground substance, have been shown to be the changes that have been observed in patients with ascorbic acid deficiency. From the present study, with its limitations, it is suggested that ascorbic acid may play a role in the pathogenesis of atherosclerosis, and although not implicated as an etiological factor in coronary artery disease, it suggests that a closer look at its possible role in the pathogenesis and progression of coronary artery disease is warranted. |
| doi_str_mv | 10.1093/ajcn/33.10.2079 |
| format | Article |
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The leukocyte ascorbic acid level was found significantly lower in patients with coronary atherosclerosis (P < 0.001). There was also significant difference in the leukocyte ascorbic acid levels among patients with abnormal coronary arteriograms who smoked compared to those who did not. The anatomical changes secondary to atherosclerotic disease, and mainly those changes related to the ground substance, have been shown to be the changes that have been observed in patients with ascorbic acid deficiency. From the present study, with its limitations, it is suggested that ascorbic acid may play a role in the pathogenesis of atherosclerosis, and although not implicated as an etiological factor in coronary artery disease, it suggests that a closer look at its possible role in the pathogenesis and progression of coronary artery disease is warranted.</description><identifier>ISSN: 0002-9165</identifier><identifier>DOI: 10.1093/ajcn/33.10.2079</identifier><identifier>PMID: 7424804</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aging ; Arteriosclerosis - blood ; Arteriosclerosis - etiology ; Ascorbic Acid - blood ; Ascorbic Acid Deficiency - complications ; Cardiac Catheterization ; Coronary Disease - blood ; Coronary Disease - etiology ; Female ; Humans ; Leukocytes - metabolism ; Male ; Middle Aged ; Sex Factors ; Smoking</subject><ispartof>The American journal of clinical nutrition, 1980-10, Vol.33 (10), p.2079-2087</ispartof><rights>1980 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-f7ddc72ba031308ead98e5c7bd996e28413830d6c5b6ff2bccdee4a5bfb078353</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7424804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramirez, J</creatorcontrib><creatorcontrib>Flowers, N C</creatorcontrib><title>Leukocyte ascorbic acid and its relationship to coronary artery disease in man</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The ascorbic acid level of the leukocytes in patients with coronary artery disease was compared to the ascorbic acid level of the leukocytes in patients without coronary artery disease as demonstrated by coronary arteriography. 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From the present study, with its limitations, it is suggested that ascorbic acid may play a role in the pathogenesis of atherosclerosis, and although not implicated as an etiological factor in coronary artery disease, it suggests that a closer look at its possible role in the pathogenesis and progression of coronary artery disease is warranted.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - etiology</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid Deficiency - complications</subject><subject>Cardiac Catheterization</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sex Factors</subject><subject>Smoking</subject><issn>0002-9165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1PAzEMxTOASinMTEiZ2K7NXe5zRBVfUgULzFHi-ETKNSlJDqn_PTm1YmOyrffzk_0IucnZMmcdX8kt2BXnaVgWrOnOyJwxVmRdXlcX5DKELWN5Ubb1jMyaMjWsnJPXDY5fDg4RqQzgvDJAJRhNpdXUxEA9DjIaZ8On2dPoaGKclf5ApY-YijYBZUBqLN1Je0XOezkEvD7VBfl4fHhfP2ebt6eX9f0mA97ymPWN1tAUSjKec9ai1F2LFTRKd12NRVvmCWO6hkrVfV8oAI1Yykr1ijUtr_iC3B199959jxii2JkAOAzSohuDaKqirUs2gasjCN6F4LEXe2926X6RMzGlJqbUBOfTPKWWNm5P1qPaof7jT5ElvTvqmP77MehFAIMWUBuPEIV25l_vX9Lsf4U</recordid><startdate>198010</startdate><enddate>198010</enddate><creator>Ramirez, J</creator><creator>Flowers, N C</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198010</creationdate><title>Leukocyte ascorbic acid and its relationship to coronary artery disease in man</title><author>Ramirez, J ; Flowers, N C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-f7ddc72ba031308ead98e5c7bd996e28413830d6c5b6ff2bccdee4a5bfb078353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - etiology</topic><topic>Ascorbic Acid - blood</topic><topic>Ascorbic Acid Deficiency - complications</topic><topic>Cardiac Catheterization</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sex Factors</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramirez, J</creatorcontrib><creatorcontrib>Flowers, N C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramirez, J</au><au>Flowers, N C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukocyte ascorbic acid and its relationship to coronary artery disease in man</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1980-10</date><risdate>1980</risdate><volume>33</volume><issue>10</issue><spage>2079</spage><epage>2087</epage><pages>2079-2087</pages><issn>0002-9165</issn><abstract>The ascorbic acid level of the leukocytes in patients with coronary artery disease was compared to the ascorbic acid level of the leukocytes in patients without coronary artery disease as demonstrated by coronary arteriography. 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| ispartof | The American journal of clinical nutrition, 1980-10, Vol.33 (10), p.2079-2087 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aging Arteriosclerosis - blood Arteriosclerosis - etiology Ascorbic Acid - blood Ascorbic Acid Deficiency - complications Cardiac Catheterization Coronary Disease - blood Coronary Disease - etiology Female Humans Leukocytes - metabolism Male Middle Aged Sex Factors Smoking |
| title | Leukocyte ascorbic acid and its relationship to coronary artery disease in man |
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